This thesis is a case study aimed at a key argument in the emerging field of Civil War medical and environmental history. While historians have long acknowledged disease as a major killer during the Civil War, only recently have environmental and medical historians turned their collective attentions to unpacking the complex interconnections of disease, environmental conditions, and culture. By examining the 58th North Carolina Infantry Regiment from the mountains of western North Carolina, this thesis asserts that the combined role of the disease environment and conditions in military camps created the massive outbreaks of disease that characterized the seasoning process of the regiment. Furthermore, the soldiers were practical in their response to conditions, weighing family, nation, and other factors in the face of death. When the threat of disease combined with personal and other factors, many soldiers deserted or took other actions of self-preservation over loyalty to the Confederacy.