The introduction of 5G technology in combination with smart cities will revolutionize the world economically and from the quality of life point of view. Different sectors will be impacted by this revolution such as (1) public health and safety, (2) mobility and transportation and (3) energy and water. This thesis will focus on Public Health and Safety. The characteristics that affect or boost the Return on Investment of 5G investments will be analyzed and a business model for the proper implementation of such investments will be presented. We will use the regression analysis to study the characteristics that affect the Return on Investment using 5G in Public Health and Safety. We will also use the VISOR model to define a business model for one of the services in Public Health and Safety namely the infectious disease surveillance. Our goal is to study this field of industry dynamics, technology and innovation and provide a holistic view from selecting the service up to identifying the business model.