b-catenin plays a dual role as a structural component of adherens junctions and as a transcriptional coactivator through its interactions with E-cadherin and TCF/LEF transcription factors, respectively. Normally, free b-catenin in cytoplasma is regulated by proteosome-dependent degradation system. In malignant tumor cell , deregulation of b-catenin degradation results in its aberrant accumulation, and leading to cancer. The goals of this study were to explore the reason of aberrant b-catenin accumulation in cervical carcinoma and evaluate the correlation between b-catenin¡BE-cadherin and p53 in different FIGO stage. Seventy paraffin embedded specimen with different FIGO stage were included in this study. Immunohistochemical staining was performed using anti-b-catenin polyclonal antibody and anti-p53 polyclonal antibody respectively and direct sequencing methods to analyze the mutation of CTNNB1 exon 13. The results showed 58 cases (82.8%) displayed cytoplasmic/nuclear b-catenin and no mutations in exon 13 of b-catenin gene, whereas no significant correlation between b-catenin expression level and tumor metastasis. However, b-catenin expression intensity had significant correlation with tumor size (p=0.008) and inversely correlated with E-cadherin (p=0.027) in different FIGO stage. The other way, the p53 staining intensity was significant correlated with b-catenin expression intensity (p=0.013) . Therefore, we suggest that mutations of CTNNB1 exon 13 may not be a reason for aberrant b-catenin accumulation in cervical carcinoma and aberrant p53 may play an important factor in accumulation of b-catenin.

Protein is a fundamental material of life. There are many kinds of proteins in the body. If one of them malfunctions, it will cause physical problems. Therefore, many scientists try to analyze the functions of proteins. It is believed that the protein structure determines its function. The more similar the structures are, the more similar their functions are. Therefore, the prediction and comparison of protein structures are important topics in bioinformatics. Typically, distance RMSD (Root Mean Square Deviation) is a method used by most scientists to measure the distance between two structures. In this thesis, we propose a new algorithm to compare two protein structures, which is based on the comparison of curves in the space. To test and verify our method, we randomly choose some families in the CATH database and try to identify them. Experimental results show that our method outperforms RMSD. Furthermore, we also use the SVM (Support Vector Machine) tool to help us to obtain the better classification.

No description available.

In today's competitive battleground, the concept of brand equity has proved to be an important source of strategic insights for marketers. This paper is starting with the B/W method developed from the analysis of over 1000 winning brands to establish a blueprint for brand growth. The winning brand achieves an outstanding place by adhering to specific laws that push purchase motive in consumers¡¦ mind. They are called growth codes. Branding is vital for Taiwan¡¦s business, no matter industry, manufacture and service, because it can create a particular value added and hold the main direction of marketing. More firms are conscious of brand marketing. A product or services with well brand equity will make consumers choose prior to rivals, called brand loyalty, reduce the marketing costs, and ultimately build a competitive advantage, such as GE, Benz, Sony. Fortunately, some Taiwan¡¦s companies gradually comprehend the brand equity can been seen an invisible asset that represent company¡¦s image, character, and core value. Just playing the role of manufacturing would generate a little bit margins than brand products do. Acer adjusts its marketing plan carefully then turns into a familiar technical brand around the world, can be a symbol in Taiwan and inspire others. Result in this study indicate that Trend from B/W method view on brand marketing. I confirm that Trend would like to be an international anti-virus service provider, on this competitive situation, being a brand-leadership position will keep their leading when viewing branding marketing is necessary. Most of all, to emphasize their distinct values closely to brand image is first step. To become absolutely a world-level software service company, such as Microsoft, Trend still continuously has space to move on, even if it leads, also decides, the anti-virus industry shape. Certainly, brand will still play the key role among the strong competition where no one does ignore the brand power. In Future, to combine innovation with marketing finely will no doubt be the grand winner. Key words: Brand marketing, Brand image, Software marketing

The finite element method since its development in the 1950’s has been used extensively in solving complex problems involving partial differential equations. The conventional finite element methods use piecewise Lagrange interpolation functions for approximating displacements. The aim of this research is to explore finite element analysis using B-spline interpolation. B-splines are piecewise defined polynomial curves which provide higher continuity of derivatives than piecewise Lagrange interpolation functions. This work focuses on the implementation and comparison of the B-spline finite elements in contrast with the conventional finite elements. This thesis observes that the use of B-spline interpolation functions can reduce the computational cost significantly. It is an efficient technique and can be conveniently implemented into the existing finite element programs.

No description available.

El objetivo del presente trabajo fue determinar la seroprevalencia del virus de la hepatitis C (VHC) y de la B (VHB) en donadores militares y civiles que acudieron al Banco de Sangre del Hospital Naval así como los factores de riesgo asociados. Se trata de un estudio transversal, descriptivo y retrospectivo, cuyos datos epidemiológicos y resultados del tamizaje general se obtuvieron de los Libros de registros del Banco de Sangre e Historias Clínicas en el caso de los donantes militares, en el período comprendido de Enero de 1999 hasta Abril de 2004. El Test de MUREX HBsAg Versión 3 y Hepanostika Anti-HBc UniForm fueron empleados para Hepatis B, mientras que para el virus de la Hepatitis C se utilizó el Test de Elisa de tercera generación. Un total de 7009 donantes fueron registrados entre 1999 y 2004. Se incluyeron en el presente estudio 320, aquellos que presentaban anticuerpos contra el virus C (anti-VHC) y, para el virus de la hepatitis B: Antígeno de superficie (AgSupHBV) y/o Antígeno Core-IgG. Los datos recolectados fueron procesados y analizados en el paquete estadístico SPSS versión 10 para Windows: Prueba de Ji cuadrado o Prueba de Fisher. RESULTADOS: La prevalencia de portadores de VHC y VHB fue de 0.74% y 0.34%, respectivamente. La mayor población de infectados se encuentra entre los 18 y 30 años y corresponde al personal de la sanidad naval para la Hepatitis B y de Infantería de Marina para la Hepatitis C. No se pudo encontrar factores de riesgo relacionados en ninguna de las dos etiologias debido a una tasa de negación del 96,4% del total de donantes. CONCLUSIONES: Los resultados demuestran una baja prevalencia de infección por virus de hepatitis B, pero elevada para la hepatitis C de acuerdo a los reportes nacionales e internacionales. La pobre o nula asociación entre los factores de riesgo y la enfermedad por hepatitis B y C, que estaría en relación a la limitada efectividad y poca utilidad de la AEC. Se hace necesario que el escrutinio, a través de la encuesta de predonación, sea mas completo, diseñando un cuestionario capaz de detectar más factores de riesgo, probablemente determinanates en la transmisión de los virus de la hepatitis B y C. / The aim of the present work was to determine the seroprevalence of the virus of the hepatitis C (VHC) and of the hepatitis B (VHB) in military and civil donors who came to the Bank of Blood of the Navy Hospital as well as the associate factors of risk. It is a question of a transverse, descriptive and retrospective study realized in the Bank of Blood, which information epidemiological and proved from the general tamizaje was obtained of the Books of records of the Bank of Blood and Clinical Histories in case of the military donors, in the included period of January, 1999 until April, 2004. Murex’s Test HBsAg Version 3 and Hepanostika Anti-HBc UniForm were used for Hepatitis B, whereas for the virus of the Hepatitis C there was in use Elisa's Test of third generation. A whole of 7009 donors was registered between 1999 and 2004.Were included in the present study 320, those who were presenting antibodies against the virus C (anti-VHC) and for the virus of hepatitis B: Surface antigen (HBsAg) and/or Antigen Core-IgG. The information was gathered, percentages were obtained and the results were analyzed by means of SPSS 10 Windows version Statistics Program: chi-square or Fisher’s Tests. RESULTS: The prevalence of carriers of VHC and VHB was 0.74% and 0.34%, respectively. The principal infection people are between 18 to 30 years old, and belong to health navy personal for HBV infection and Marine Infantry for HCV infection. It couldn’t find risks factors in relation to the two etiologists, due a negative rate of 96,4%. CONCLUSIONS: The results suggest a low prevalence of infection for VHB but high for VHC infection in the studied population as it are indicate in the national and international reports. The poor or useless association between de risks factors and the illness it could be in relation to a limited effective and a poor utility of de Confidential Autoexclusion Exam. It’s necessary that this exam must be complete and have the property to identify more risks factors on the transmission of HBV and HCV.

Texte remanié de: Dottorato di ricerca--Letteratura--Napoli--Università degli studi di Napoli, 2003. / Notes bibliogr.

Doktorsavhandling--Litteratur--Uppsala Universitet, 2001. / Bibliogr. p. 318-330.

Thèse de doctorat : Sciences de la vie et de la santé : Strasbourg 1 : 2007. / Thèse soutenue sur un ensemble de travaux. Titre provenant de l'écran-titre. Bibliogr. f. 208-216.