The first aim of this thesis is to examine relationships between microRNAs targeting gene networks, combining knowledge from microRNA prediction databases into our microRNA Data Integration Portal (mirDIP). Modeling the microRNA:transcript interactome – referred to as the micronome – to build microRNA interaction networks of signalling pathways, we find genes within signalling pathways to be co-targeted by common microRNAs suggesting an unexpected level of transcriptional control. We identify two distinct classes of microRNAs; universe microRNAs, which are involved in many signalling pathways; and intra-pathway microRNAs, which target multiple genes within one signalling pathway. We find universe microRNAs to have more targets, to be more studied and more involved in cancer signalling than their intrapathway counterparts. The second aim was to undertake a more focused view, analyzing the characteristics of microRNAs within the micronome itself beginning with a focus on the under-examined microRNA terminal loop across the micronome to determine if this region of the microRNA structure might contribute to microRNA functioning. We have identified 2 main classes of microRNAs based on loop structure – perfect and occluded, which show biological relevance. We found regulatory motifs within microRNA terminal loops and found a large number of Frequently Occurring Words (FOWs) significantly overrepresented across the micronome. Set analysis of in vitro secreted microRNAs, microRNA expression across a panel of normal tissues, and microRNAs shown to be secreted in lung cancer shows that specific microRNA loop motifs within these groups are significantly overreperesented – suggesting that microRNA terminal loops harbour sequences bearing microRNA processing and localization signals.

The complementary advantages of GPS and INS have been the principle driving factor to integrate these two navigation systems as an integrated GPS/INS system in various architectural forms to provide robust positioning. Although the loosely coupled and tightly coupled GPS/INS systems have been in existence for over a decade or two and performed reasonably well, nevertheless, the tracking performance was still a concern in non-benign environments such as dynamic scenarios, indoor environments, urban areas, under foliages etc., where the GPS tracking loops lose lock due to the signals being weak, subjected to excessive dynamics or completely blocked. The motivation of this research, therefore, was to address these limitations with an integrated GPS/Pseudolite/INS system using ultra-tight integration architecture. The main research contributions are summarised as below: (a) The performance of the tracking loops in dynamic scenarios were analysed in detail with both conventional and ultra-tight software receivers. The stochastic modelling of the INS-derived Doppler is of utmost importantance in enhancing the benefits of ultra-tight integration, and therefore, two popular stochastic techniques??? Gauss Markov (GM) and Autoregressive (AR), were investigated to model the Doppler signal. The simulation results demonstrate that the AR method is capable of producing better accuracies and is more efficient. The algorithms to determine the AR parameters (order and coefficients) were also provided. (b) The various mathematical relationships that elicit the understanding of the ultra-tightly integrated system were derived in detail. The Kalman filter design and its implementation were also provided. Various simulation and real-time experiments were conducted to study the performance of the filter, and the results confirm the underlying assumptions in the theoretical analyses and the mathematical derivations. Covariance analysis was also performed to study the convergence and stability effects of the filter. (c) Interpolator design using signal processing techniques were proposed to increase the sampling rate of the INS-derived Doppler. To efficiently realise the interpolator transfer function, two optimal techniques were investigated ??? Polyphase and Cascaded Integrator Comb (CIC), and our results show that CIC was more efficient than polyphase in accuracy and real-time implementations. (d) The integration of Pseudolites (PL) with INS in ultra-tight configuration was analysed for an indoor environment. The acquisition and tracking performances of ???Pseudolites-only??? and ???Pseudolite/INS??? modes were compared to study the impact of the inertial signals aiding. The results demonstrate that aiding of the inertial signals with the baseband loops (acquisition and tracking) improve the overall tracking performance. An overview on the effects of the pseudolite signal propagation is also given. (e) Simulation and real-time experiments have been conducted to evaluate the proposed algorithms and the overall design of the ultra-tightly integrated system. A comparison was also done between GPS/PL/INS and GPS/INS integrated systems to study the potential advantages of the pseudolite integration. The details of the field experiment are provided. The data from a real-time experiment was processed to further evaluate the robustness of the system. The results confirm that the developed mathematical models and algorithms are correct.

Thesis (M. App. Sc.)--Carleton University, 2003. / Includes bibliographical references (p. 103-105). Also available in electronic format on the Internet.

Thesis (MS)--Montana State University--Bozeman, 2009. / Typescript. Chairperson, Graduate Committee: Brock LaMeres. Includes bibliographical references (leaves 64-66).

Thesis (M. S.)--Electrical and Computer Engineering, Georgia Institute of Technology, 2008. / Committee Chair: Laskar Joy; Committee Member: Cressler John; Committee Member: Tentzeris Emmanouil

Thesis (Ph. D.)--State University of New York at Binghamton, Department of Mathematical Sciences, 2008. / Includes bibliographical references.

Thesis (Ph.D.)--Memorial University of Newfoundland, 1999. / Bibliography: leaves 119-122.

Thesis (M.S.)--Oregon State University, 2006. / Printout. Includes bibliographical references (leaves 47-48). Also available on the World Wide Web.

Thesis (Ph. D.)--University of Texas at Austin, 2005. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--University of Texas at Austin, 2005. / Vita. Includes bibliographical references.