Charles University Faculty of Pharmacy in Hradec Králové Department of pharmeceutical technology Candidate: Oksana Yanok Supervisor: Pharm.Dr. Andrej Kováčik, Ph.D. Title of Diploma Thesis: The effects of glucosyl sphingosine on barrier function of skin and complex skin model. The skin barrier, which provides protection from water loss and harmful environmental influences is located in the stratum corneum. The dominant group of lipids within the stratum corneum are ceramides (Cer), which also have the most important role in ensuring the barrier properties of the skin. The enzymes sphingomyelin deacylase and glucosylceramide deacylase hydrolyze the amide bond of Cer precursors, which leads to highly polar metabolites, called lysolipids. The increased activity of these enzymes is considered to be one of the major factors leading to the development of a number of skin diseases characterized by a skin barrier disorder (for example atopic dermatitis). In this study we prepared model membranes mimicking a healthy skin barrier as an equimolar mixtures of human Cer, cholesterol, free fatty acids with the addition of 5 % cholesterol sulfate. We also prepared models in which the amount of Cer was gradually reduced and replaced by the hydrophilic lysolipid glucosylsphingosine. The permeability was measured...

The damage assessment caused by floods, earthquakes, hurricanes among others phenomenons in the world are analyzed with methodologies such as "Vulnerability curves". In Peru, disasters caused by hyperconcentrated flows are alarming due to a climatic variability such as the "El Nio Costero"phenomenon. Therefore, this research has developed vulnerability curves for 1 and 2-story confined masonry buildings in Urb. San Idelfonso, Ica - Peru; linking the variables: flow depth, associated with the event produced by heavy rains at the top of the "Quebrada Cansas"caused by the "El Nio Costero"phenomenon in 2017, and the percentage of the damage based on the methodology of the United States Army Corps of Engineers (USACE), whose formula is the repair value and total building value. The monetary amounts and items of the buildings are obtained from the RM 415-2017-VIVIENDA of the Ministry of Housing, Construction and Sanitation of Peru. The process consisted of hydrological modeling in HEC-HMS, hydraulic modeling in FLO-2D, damage percentage estimate and vulnerability curves production. Finally, the vulnerability curves for hyperconcentrated flows were contrasted with similar studies regarding curves for flooding and debris flow. The results of the investigation showed that the "El Nio Costero"phenomenon in 2017 had an economic impact of at least 1.3 million soles in Urb. San Idelfonso. In addition, at least 24 buildings had a complete damage and 21 buildings an extensive damage.

<p style="text-align: justify;">U okviru disertacije je na osnovu teorijske i&nbsp;empirijske analize i kori&scaron;ćenjem podataka iz<br />eksploatacije, formiran model pouzdanosti&nbsp;koji će doprineti povećanju pouzdanosti i<br />sigurnosti funkcionisanja dizel motora u&nbsp;procesu eksploatacije.</p> / <p>Within this dissertation, on the basis of&nbsp;theoretical and empirical analysis and usage of<br />exploitation data, a reliability model was formed&nbsp;that will contribute to reliability increase and&nbsp;safety of diesel engine operation in the&nbsp;exploitation process.</p>

The characterization of damping is important in making accurate predictions of both the true response and the frequency response of any device or structure dominated by energy dissipation. The process of modeling damping matrices and experimental verification of those is challenging because damping can not be determined via static tests as can mass and stiffness. Furthermore, damping is more difficult to determine from dynamic measurements than natural frequency. However, damping is extremely important in formulating predictive models of structures. In addition, damping matrix identification may be useful in diagnostics or health monitoring of structures. The objective of this work is to find a robust, practical procedure to identify damping matrices. All aspects of the damping identification procedure are investigated. The procedures for damping identification presented herein are based on prior knowledge of the finite element or analytical mass matrices and measured eigendata. Alternately, a procedure is based on knowledge of the mass and stiffness matrices and the eigendata. With this in mind, an exploration into model reduction and updating is needed to make the problem more complete for practical applications. Additionally, high performance computing is used as a tool to deal with large problems. High Performance Fortran is exploited for this purpose. Finally, several examples, including one experimental example are used to illustrate the use of these new damping matrix identification algorithms and to explore their robustness. / Ph. D.

This Diploma thesis deals with problematics of new enterprises and factors, which are critical for them and for their success or failure in their early years of entrepreneurship (5 years). The main aim of this diploma thesis is to identify these factors and suggest recommendation, which will lead to better ability of surviving and increases their probability of surviving. For research in this thesis will be used data of the small and medium sized companies (100). These data are collect randomly within electrical and electronic engineering industry. Needed companies were founded in websites ebd.cz and merk.cz. Basic data were gained from basic financial statements of companies, which their posted on website justice.cz. These financial statements are balance sheet and Profit and Loss statement. The data were processed using software power BI, which is using in business intelligence. The second aim of this diploma thesis is also to verify selected bankruptcy and solvency models on chosen data.

Helísková, E. The increase of the efficiency of a company with benchmarking. Diploma thesis. Brno: Mendel University, 2019. The purpose of this diploma thesis is to propose suitable suggestions to increase the efficiency of the construction company Geprostav, based on the analysis and comparison with the benchmarking partner. In the summary of the literature the basic theoretical information about the method of benchmarking and about the rating of the efficiency of a company has been stated. Besides the description of the index, on which the financial condition of companies is regarded and compared, the Model excellence EFQM is described there. The Model excellence EFQM is the basis of appreciation of the non-financial factors as well. In the next part, the analysed company and the benchmarking partner are introduced. Pursuant the comparing analysis, the significant deficiencies have been identified and suitable measures are suggested.

A thesis submitted to the Faculty of Education in fulfilment of the requirements for the Degree of Doctor of Education in the Department of Educational Psychology and Special Education at the University of Zululand, 2018 / This study investigated the resilience among Orphans and Vulnerable Children (OVC) in KwaZulu-Natal schools. It identified OVC challenges and developed a psychosocial model of intervention. The Social Ecological Model was adopted as a framework for the study. The study adopted the mixed method research design. The population for the study was the OVC, caregivers and teachers from Kwazulu-Natal schools, specifically Amajuba and Zululand Districts. Random selection was done for OVC from mainstream schools. Purposive sampling method was used to select OVC from special schools, schools near the orphanage, home of safety and a Full Service school. The sample which participated during quantitative data collection consisted of 303 OVC from 12 to 20 years old who were selected from 7 school in Amajuba and Zululand Districts.The sample which participated in qualitative data collection consisted of 4 focus groups and those were 6 caregivers, 6 teachers and 12 OVC. OVC were selected from 303 OVC who filled the questionnaires and CYRM-28. This made a total of 24 participants for focus groups. The total of participants for the whole study was 315. Three instruments were used to collect data for this study, namely; the Child and Youth Resilience Scale-28 (CYRM-28), the self-constructed psychosocial questionnaire and the interview schedule. The CYRM-28 was used to measure the extent of OVC resilience with the self-constructed questionnaire. Both descriptive and inferential statistics were used to analyse data. Frequencies were created for descriptive data and the Chi-Square statistical technique was used to test the null hypothesis. Then the thematic content analysis was used to identify themes from the focus group interviews. The results of descriptive statistics indicated that 79% of all participants reported high availability of resources that enabled resilience. Fewer resources were reported for children who had experienced abuse, followed by those with disabilities and more resources were reported for orphans. The main challenges of OVC identified were lack of support from teachers and neighbours/ communities. Other challenges included maltreatment by caregiver, OVC behavioural problems, unavailability of documents for social grant applications. Child Headed Household was identified as lacking all resources. The findings of inferential statistics indicated that there is a significant relationship between the age, gender and custody of OVC and their availability of resources. OVC and caregivers encountered various problems which were risk factors for the resilience of OVC. Availability of resources to a majority of OVC who participated in the study was a protective factor. Participants recommended that more resources which promote resilience of OVC be made available to communities, for examples, old age homes, and entrepreneurship skills, continuous counselling services for caregivers and OVC and recreational facilities for communities. Lastly, the psychosocial model of intervention was developed based on the literature and findings of the study. / Natonal Research Foundation National Institute for Humanities and Social Sciences (NIHSS)

The objective of this dissertation is the development of computer simulation-based models for the modeling of upper ionosphere, starting from the first principles. The models were validated by exact analytical benchmarks and are seen to be consistent with experimentally obtained results. This area of research has significant implications in the area of global communication. In addition, these models would lead to a better understanding of the physical processes taking place in the upper ionosphere.

Traditional macroeconomics believes that confidence is not the main cause of economic fluctuations, but when faced with financial crises, monetary authorities still emphasize the role of stabilizing confidence. Although people generally agree that confidence is an important part of the transmission of macro-policies to micro- individuals, there is neither empirical evidence support nor corresponding mechanism research. This thesis attempts to answer the following questions: Does business confidence affect the effectiveness of monetary policy? Does business confidence have the same impact on monetary policy in different economic periods? This thesis first constructed a structural vector auto-regression (SVAR) model to test the role of business confidence in the transmission of monetary policy in the euro area. The empirical results show that expansionary monetary policy can effectively boost business confidence while stimulating output growth. In addition, this thesis extends the model by introducing share prices and exchange rates to investigate the role of these two important to the monetary transmission mechanism, concluding that business confidence plays a strong role in interest rate transmission and a weaker role in the transmission of asset prices and exchange rates. Subsequently, in order to...

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