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The influence of flutamide, tamoxifen and dietary fat on hormone-induced mammary carcinogenesisLeung Wai, Ching-wa, Gina. January 2002 (has links)
Thesis (Ph.D.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 201-254) Also available in print.
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In vivo characterization of RIF-1 tumors via diffusion and fluorine-19 NMR methods.Meiler, Michael Rudolf. January 1999 (has links)
Thesis (M.S.)--Worcester Polytechnic Institute. / UMI no.: 99-34691. Includes bibliographical references (leaves 195-206).
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Deregulated E2F1 has both oncogenic and tumor suppressive properties in mouse skin /Pierce, Angela Marie, January 1998 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 97-114). Available also in a digital version from Dissertation Abstracts.
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The modulation of effect of fatty acids on the lipid in colon epithelial mucosa in Vivo /Abrahams, Celeste H. January 2009 (has links) (PDF)
Thesis (M.A. (Dept. of Medical BioScience, Faculty of Natural Sciences))--University of the Western Cape, 2009. / Includes bibliographical references.
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Expression of the DNA mismatch repair protein MLH1 in serrated polyps of the colon : an immunohistochemical study /Chan, Ling-fung. January 2005 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2006.
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TGF-[beta] signaling in stromal contribution to prostate cancer progressionAo, Mingfang. January 2006 (has links)
Thesis (Ph. D. in Cancer Biology)--Vanderbilt University, Aug. 2006. / Title from title screen. Includes bibliographical references.
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Development of an analytical method to measure 17BETA-estradiol metabolite concentrations in MCF-7 and MCF-12A cell linesVan Zyl, Hermia. January 2004 (has links)
Thesis (MSc.(Physiology)--Faculty of Health Sciences)-University of Pretoria, 2004. / Also available on the Internet via the World Wide Web.
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Transcriptional regulation and the role of murine 8S-lipoxygenase in mouse skin carcinogenesisKim, Eunjung, Fischer, Susan M. January 2004 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisor: Susan M. Fischer. Vita. Includes bibliographical references.
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Modeling and analysis of the ErbB signaling network from single cells to tumorigenesis /Birtwistle, Marc Russel. January 2009 (has links)
Thesis (Ph.D.)--University of Delaware, 2008. / Principal faculty advisors: Babatunde Ogunnaike, Dept. of Chemical Engineering; and Boris N. Kholodenko, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University. Includes bibliographical references.
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Efeitos da temperatura e do mate (Ilex paraguariensis) sobre o processo de carcinogênese de esôfago em ratos wistar machosSilva, Juliana Ferreira da [UNESP] 17 September 2008 (has links) (PDF)
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silva_jf_me_botib.pdf: 326535 bytes, checksum: fe0aa6d59a3acd2eb778f89a8d92390b (MD5) / Universidade Estadual Paulista (UNESP) / O consumo de mate em altas temperaturas tem sido considerado um fator de risco para o desenvolvimento do carcinoma epidermóide de esôfago (CE) na América do Sul. Desta forma, os efeitos da ingestão de mate sobre danos de DNA e a carcinogênese de esôfago, induzidos pela dietilnitrosamina (DEN) e injúria térmica, foram avaliados em ratos Wistar machos. Na fase de iniciação, os animais foram iniciados com injeções i.p. da DEN (8 x 80 mg/Kg p.c.) e submetidos a injúria térmica (água a 65°C, lmIlrato, instilado no interior do esôfago) e receberam, concomitantemente, mate (2.0% p/v, grupo teste) ou chá-verde (2.0% p/v, grupo controle positivo) como única fonte de líquidos por oito semanas. Nenhum tratamento adicional foi introduzido durante a fase de pós-iniciação (nona a vigésima semana do experimento). Amostras de sangue periférico foram coletadas quatro horas após a última administração da DEN para o teste do cometa na oitava semana e amostras de esôfago e fígado foram coletadas na oitava e vigésima semanas do experimento. Na oitava semana, a ingestão de mate e chá-verde por si não foi genotóxica e reduziu de forma significativa os níveis de danos no DNA de leucócitos de sangue periférico nos animais tratados com a DEN. Além disso, uma redução significativa nos níveis de proliferação celular no epitélio do esôfago e no parênquima hepático e no número de lesões hepáticas pré-neoplásicas foram também observadas nos grupos iniciados e que receberam mate ou chá-verde. Na vigésima semana, uma menor incidência de neoplasias de esôfago e fígado foi observada nos grupos que receberam previamente mate e chá-verde quando comparado ao grupo iniciado pela DEN e submetido à injúria térmica. Os resultados do presente estudo indicam que a ingestão de mate se mostrou benéfica contra danos no DNA e a carcinogênese de esôfago e fígado induzidos pela DEN. / Drinking hot mate has been associated with risk for esophageal squamous cell carcinoma m South America. Thus, the modifying effects of mate tea intake on DNA damage and esophageal carcinogenesis induced by diethylnitrosamine (DEN) plus thermal injury were evaluated in male Wistar rats. In the initiation phase, rats were treated with DEN injections (8 x 80 mg/Kg b.w.) plus thermal injury (water 65°C, lml/rat, instilled into the esophagus) and concomitantly received mate tea (2.0% w/v, test group) or green tea (2.0% w/v, positive control group) as the sole source of drinking fluid for 8 weeks. Any additional treatment was introduced at post-initiation until week 20. Peripheral blood was collected 4 hr after the last DEN application for comet assay at week 8 and samples from esophagus and liver were collected at weeks 8 and 20. At week 8, mate or green tea intake itselfwere non-genotoxic and significantly decreased DNA damage levels in peripheral blood leucocytes from DEN-treated animaIs. Also, a significant reduction of cell proliferation rates in both esophageal epithelium and liver parenchyma and on the number of putative preneoplastic liver lesions were observed in initiated and mate or green tea-treated animaIs at week 8. A significant lower incidence of esophageal and liver neoplasms and tumor multiplicity was observed in the groups previously treated with mate or green tea when compared to the DEN initiated/thermal injury group at week 20. These data indicate that mate tea presented protective effects against DNA damage and esophageal and liver carcinogenesis induced by DEN.
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