Blazars are a subclass of active galactic nuclei whose observable characteristics are generated by relativistic jets of high-energy plasma with trajectories closely aligned to the line of sight. This orientation results in extreme observed phenomena, such as ultraluminous emission, high amplitudes of variability, and high degrees of optical linear polarization. Furthermore, blazars are the most common extragalactic sources of γ-ray photons and have been proposed as sources of high-energy neutrinos. Long-timescale monitoring of blazars has revealed relatively quiescent states interspersed with active states featuring dramatic brightening events, with timescales ranging from months to years. New, high-time-resolution observations of blazars are revealing dramatic variability on timescales as short as several minutes, the physical drivers of which are not well understood. In this dissertation, I focus on observational signatures that can potentially identify these mechanisms. To characterize this variability, I combine observations of blazars from many telescopes, obtaining a comprehensive view of events occurring in the jets. Using the Very Long Baseline Array, I investigate moving and quasi-stationary features in the parsec-scale jets of 38 blazars. I find that the flow speeds, orientation, brightness temperatures, and opening angles of the jets in flat-spectrum radio quasars (FSRQs), BL Lacertae type objects (BL Lac objects), and radio galaxies (RGs) are statistically different, with FSRQs having the highest speeds and smallest viewing angles. Focusing on a typical source of each subclass, I characterize the optical variability observed at 2-min cadence (with the Transiting Exoplanet Survey Satellite), at gamma-ray energies (Fermi Large Area Telescope), X-ray energies (NICER, NuSTAR, and Swift satellites), and optical (ground-based instruments, especially, the Perkins telescope), including linear polarization measurements. I find that the minimum timescale of RG variability is longer than those of the FSRQ and BL Lac object, and is likely caused by changes in the accretion disk. In contrast, the variability in the FSRQ and BL Lac object can be associated with shocks, magnetic reconnections, and turbulence in the jet. The unprecedented availability of data, which promises to expand in the future, represents a new phase of observational astronomy that provides valuable information on changes in the jets of blazars.

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Yes / Objective: This article gives an in-depth insight into the ways in which communication between midwives and the birthing woman shape the birth experience. Background: Birth is a significant life event for many women that can have profound, long-lasting effects on how they see themselves as women and mothers. Within the literature the importance of control over the birth experience and the support that the birthing woman receives from midwives is stressed. Methods: Six women who had recently given birth participated in one-to-one semi-structured interviews designed to explore the kinds of support they received before, during and after their birth. An inductive thematic analysis was employed in order to identify and explore key issues which ran throughout the interviews. Results: Within the interviews the importance of being an active mother, someone who made decisions in relation to her labour, was stressed. The analysis explores the ways in which communication style and compassionate care either enabled or prevented women from adopting the position of ‘active’ mother. Conclusion: It is argued that a personal connection with midwives and clear and open communication which places the birthing woman in a position of control are key to positive birth experiences.

In this work, the potential of an active-skin is demonstrated for the reduction of broadband acoustic radiation from a vibrating structure. A simplified representation of the active-skin, employing acoustic monopoles as secondary sources, is explored as a precursor to the more complicated analyses of the device. Many design issues are addressed at this stage, taking advantage of the simplicity of this model. Numerical Methods, such as the Finite Element Method (FEM), are employed in the development of both structural and acoustic models for the active-skin. These modeling techniques are also employed for the primary structure, a simply-supported steel plate. The obtained models of the plate are validated using both theoretical and experimental comparisons. Experimental results are also used to verify the structural and acoustic models of the active-skin. Integration of these models into the control simulation provides a methodology for investigating the control characteristics of the active-skin. Two different skin configurations are investigated. The first employs the active-skin as a partial covering of a steel plate, while in the second configuration the active-skin completely covers a clamped aluminum plate. In each case, experimental results are presented, in which microphones are used as error sensors, for validation of the analytical active-skin model. The model is then used to investigate the effect of Structural Acoustic Sensing (SAS) on the control performance as an alternative to microphone error sensing. The adaptive feedforward Filtered-x Least-Mean-Square (LMS) algorithm is employed for both analytical and experimental control simulations showing the utility of such an active-skin in the control of structure-borne sound. A summary of the analytical and experimental findings is given and conclusions are drawn from these findings regarding the potential for the active-skin in the broadband attenuation of structurally radiated sound. / Master of Science

The characteristics of an automotive passenger seat in response to vibrational excitations are examined and an active vibration isolation system incorporating smart materials is designed, built, and tested. Human sensitivity to vibration is discussed. Characteristics of road roughness are discussed and used to implement a representative test input to a passenger seat system. extsc{Matlab} is used to model the car seat and vehicle system with four degrees of freedom to determine actuator requirements. Selection and implementation of a low--profile, prestressed piezoceramic device into an active seat suspension system is described, and experimental results of the actuator assembly performance are presented. Vibration isolation is realized in an experimental setup representing one quarter of a seat and passenger's total mass, using one actuator assembly (representing one corner of the seat suspension). For an input power spectrum representative of a passenger vehicle environment, the smart material actuator assembly, as applied to a quarter seat experimental setup, is proven to be capable of isolating vibration with an isolation frequency of 2Hz and no resonant peak, versus 6Hz and a resonant peak of 2g/g for an actual passenger seat tested. / Master of Science

Weight is a critical parameter in the design of any system launched into space. Current launch costs are on the order of 10,000 dollars per pound of payload capacity. Reducing weight and thus increasing payload capacity is always in the forefront of the design process. One method of increasing the payload capacity of launch vehicles is to reduce the acoustic environment in the interior of the fairing. A major problem is that passive methods currently used for noise suppression do not exhibit significant energy dissipation at low frequencies. This motivates the use of active noise control. Using active noise control for frequencies below 200 to 300 Hz in addition to the passive control means has potential to provide broadband noise suppression and thus a smoother, cheaper ride for any payload. The problem with this technique is that active noise control commonly uses electromagnetic speakers as the control element. The weight of the speaker adds more cost to the application due to the approximate cost per pound to send a launch vehicle and payload to space. At 10,000 dollars per pound of payload capacity, the added cost spent on protecting the payload can potentially reduce the amount of payload capacity a customer receives due to monies spent on non-payload mass. Therefore, necessity dictates a light weight noise control solution. This work investigates the feasibility of a transducer with less mass than that of a conventional loudspeaker which dissipates energy at the acoustic resonances of an enclosed cavity. The test setup involves using the transducer to lower the sound pressure levels of acoustic resonances which are excited by an external source, thus simulating the launch phase of a launch vehicle. The transducer is used as an actuator to add damping through feedback control. The transducer is comprised of three thin flexures that are actuated by piezoceramic material attached to both sides. The flexures actuate a speaker cone that is attached to the end of the flexures. The transducer can act as a sensor or an actuator due to the nature of the piezoceramics. The sound absorbing transducer is modeled to couple to the first acoustic resonance of a six foot cylindrical cavity. The cavity acts as a simplified model of a launch vehicle payload fairing. Equations of motion are derived to model actuator motion and the acoustic impedance of the cavity. A state-space model of the system was derived for two cases: a collocated sensor/actuator pair exciting the tube and an external source exciting the tube with the transducer acting as an absorber. The transducer is designed to affect the first mode, however damping is noticed in the next acoustic resonance. Analysis of the theoretical model indicated up to 70 percent reduction of the open-loop RMS values or a reduction of 10 dB. Experimental results with the optimized transducer produced a 35 percent reduction of the open-loop RMS value or 3.73 dB. The first acoustic resonance coupled well with the first structural mode of the transducer providing optimal noise suppression for the first mode. Damping was also noted in the second acoustic mode. Neglecting the inertia of the tip mass introduced errors in the predictions of the transducer resonances at higher frequencies. This problem limited the ability to control the higher modes of the cavity. / Master of Science

This study examined the effect of active learning seminars and a mentoring program on the use of active learning teaching techniques by college faculty. A quasi-experimental study was conducted using convenience samples of faculty from two private Christian supported institutions. Data for the study were collected from surveys and faculty course evaluations. The study lasted one semester. Faculty volunteers from one institution served as the experimental group and faculty volunteers from the second institution were the comparison group. The experimental group attended approximately eight hours of active learning seminars and also participated in a one-semester mentoring program designed to assist faculty in application of active learning techniques. Several individuals conducted the active learning seminars. Dr. Charles Bonwell, a noted authority on active learning, conducted the first three-hour seminar. Seven faculty who had successfully used active learning in their classrooms were selected to conduct the remaining seminars. The faculty-mentoring program was supervised by the researcher and conducted by department chairs. Data were collected from three surveys and faculty course evaluations. The three surveys were the Faculty Active Learning Survey created by the researcher, the Teaching Goals Inventory created by Angelo and Cross, and the college edition of Learner-Centered Practices by Barbara McCombs. The use of active learning techniques by the experimental group increased significantly more than the use by those in the convenience sample. No statistical difference was found in the change of professors' teaching beliefs or the course evaluation results.

This paper is the use of the active inductor instead of passive inductors to save area, enter the match aspects of the use of the feedback capacitor in parallel with the resistor to achieve matching with the control input voltage, in addition to adjusting the feedback resistor can control the noise. The LNA dissipates 13.2 mW power and achieves input return loss (S11) below -10dB, output return loss (S22) below -10 dB, forward gain (S21) of 11.3~14.5dB, reverse isolation (S12) below -40dB, and noise figure (NF) of 3~3.18 dB. 1-dB compression point (P1dB) of -24 dBm and input third-order inter-modulation point (IIP3) of -14 dBm .

Oxygen is one of the most important molecules in human beings. Our research is focused on how the human body can respond and adapt to the physiological challenge posed by a lack of oxygen. Ascorbic acid (Vitamin C) is one of the most important and considered the most effective water-soluble, chain-breaking antioxidant in human plasma, with the capacity to prevents damage by free radicals. This thesis presents four studies investigating the phenomenon of Reactive Oxygen Species (ROS) generation in the many different surgical conditions in the animal and in the human. Study one investigated the geometry and thermodynamic properties of vitamin C. Calculations were carried out at the restricted and unrestricted B3LYP/6-31+G(d,p), B3LYP/6-311++G(d,p) and B3LYP/EPR-II levels for two conformers (1 and 2) of L-ascorbic acid and their respective oxidation products to monodehydroascorbates of ab-initio methods by Gaussian O3W package. Conformer 1, free radical properties are compared with previously published calculations in the gaseous and aqueous solution states and with experimental EPR values. Calculated molecular structures, EPR (electron paramagnetic resonance spectroscopy), the vibration spectral and energetic properties and all are reported including some proposed changes to previous EPR assignments. Conformer 2 of L-ascorbic acid is predicted to have lower energy than Conformer 1, under the method and basis sets used, by between 11 and 26 kJ mol-1 and is stabilised by internal hydrogen bonding. Relaxed potential energy surface (PES) scans were carried out for two proton transfer processes and relative energies of stable minima and barriers between them determined. Hydrogen transfer is predicted in two systems with favourable spatial arrangements of O–H and O groups for which relaxed potential energy surface scans are reported. Calculated vibrational wavenumber values are provided for selected C=C, C=O, C–H and O–H modes assigned to particular groups and significant calculated EPR hyperfine coupling constants (HCC) values for splitting by H(1) and C(13) for radical species are also reported. These calculations contribute to a better understanding of the complex role of L-ascorbic acid and its various oxidised, neutral, ionic and radical forms in biochemistry and medicine. Study two examined if vitamin C could ameliorate the damaging effects of I-R on myocardium and we postulated that the mechanism of vitamin C protection against iii I-R-induced cell death involved quenching of ROS. In the vitamin C group after 5 min of reperfusion a significant, sudden increase of diastolic pressure in the heart was noted and reached a maximum of 77 mmHg after 12 min of reperfusion and then gradually decreased to 51 mmHg after 60 min of reperfusion period but was quicker than in Control group reaching 37 mmHg by the end of the reperfusion period. The level of A·− (ascorbate free radicals) sudden and massive increased at the time of reperfusion in the Vitamin C group. This increase was associated with poor mechanical function in hearts as indicated by the significantly depressed recovery process. After 30 min of global, now-flow ischaemia and 60min of reperfusion infarct size averaged 33% ± 1 in Control group and 30 % ± 1 in Vitamin C group, respectively, (P<0.05). There is strong evidence that oxygen centered radicals contribute to postischaemic dysfunction after global ischaemia. Our data unquestionably suggest that the large production of A·− was associated with a greater depression in myocardial contractile function, therefore could represent a marker of oxidative stress during I-R and could be related to the functional impairment during reperfusion. In summary, we have used the animal models of isolated heart perfusion to provide evidence that vitamin C did not reduce the infarct size, however “tendency” towards a decrease (↓) in infarct size with ascorbate and it protects from oxidative damage during global I-R as manifested by decreased concentrations of A·− and enhance recovery of mechanical function such as diastolic pressure and LVDP in postischaemic working rat hearts. Study three was designed to test the hypothesis that the physiological trauma associated with venous cannulation may artefactually stimulate systemic free radical formation in the acute phase that if not accounted for may under-estimate the oxidative stress response to exercise. The relationship between the time of venepuncture and the level of free radical generation during normoxic conditions was further investigated. The venous cannulation in Phase I, increased plasma A·− by 347 ± 173 AU/√G, P <0.05 after 2min of venepuncture with further increases observed after 5min and 10min of venous cannulation, respectively (403 ± 178 AU/√G; 462 ± 93 AU/√G, P < 0.05) vs baseline point time. After this time the level of A·− slightly blunted as to achieve a similar level to baseline point control after 30 minutes. In phase II the exerciseinduced increase in A·− was subsequently shown to be 48% greater (30min as opposed to the 2min post-cannulation resting baseline)(1754 ± 361 vs. 1979 ± 375 AU, P <0.05). Our findings demonstrate and confirm that venous cannulation per se stimulates iv the systemic formation of free radicals as an acute phase response which peaks at 10min and require approximately 15min to normalise. This has important interpretive implications for future studies that employ catheterisation. The final Study examined if the combination of exercise and inspiratory hypoxia would further compound regional tissue de-oxygenation that is frequently encountered during the ischaemic phase of surgery and thus, by consequence increase oxidative stress. The aim of the study was to further understand a potential relationship between oxidative stress and alterations in muscle oxygenation. Clear significant increases in the plasma concentration of A·− were detected in the peripheral blood of patients (normoxia(baseline) vs 6 data points of reperfusion after 5min of global ischaemic condition, P<0.05),(baseline vs immediate after ischaemia; 2337±525 vs 2633±508, AU, respectively). During global ischaemia the regional muscle oxygenation significantly decreased (↓∆O2Hb-oxyhaemoglobin), ↑∆HHb- deoxyhaemoglobin ), although increased regional blood volume (↑∆tHb- total haemoglobin). From the end of global ischaemia to 10 min after the regional muscle oxygenation progressively back to the start data point (↓∆HHb, ↑∆O2Hb). This study demonstrates for the first time that the I-R has got a big influence on the muscle oxygenation to increased ROS and the return of values towards baseline period in reperfusion stage appears to coincide with increased oxidative stress. Moreover, the present study has also demonstrated increased A·− level as early as the ischaemic phase of experiment independent of perioperative changes in the partial pressure of oxygen (pO2), elucidate a potentially important role for oxidative stress in provoking an appropriate vasodilation (NO-bioavailability) during the I-R period. This work demonstrates that; - Ascorbate is an antioxidant that can scavenge tissue and blood borne free radical, is essential in controlled amounts and is capable of initiating protective adaptation in the face of oxidative stress for the maintenance of physiological homeostasis. - Reperfusion is always associated with a sudden and massive release of ascorbate free radicals, with a maximal liberation within the first minutes of reperfusion. Vitamin C tended to reduce infarct size and protects from oxidative damage during global ischaemia and reperfusion. - The venous cannulation alone is enough per se stimulates the systemic formation of free radicals as a acute phase response. If this baseline artefact is not taken into account, the true magnitude of the exercise-induced oxidative stress response will be under-estimated. / The I-R has got a major influence on the muscle oxygenation to increased ROS and the return of values towards baseline period in reperfusion stage appears to coincide with increased oxidative stress. Using the state-of-the-art molecular techniques that include Electron Paramagnetic Spectroscopy (EPR) for the direct detection of free radicals and Near Infrared Spectroscopy (NIRS) for the direct detection of muscle oxygenation these studies have attempted to translate the basic mechanisms associated with free radical formation during I-R and have provided unique insight into the basic mechanisms responsible for the oxidative stress with the ultimate objective of developing novel antioxidant interventions that can provide effective prophylaxis.