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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
31

Biochemical pharmacology of dideoxynucleoside analogues active against HIV

Hoggard, Patrick G. January 1996 (has links)
No description available.
32

The pharmacological basis for therapeutic failure in Toxoplasma gondii

Szwandt, Ian Simon Francis January 2001 (has links)
No description available.
33

Psychiatric morbidity in homosexual men with HIV-infection in Sao Paulo, Brazil : prevalence, risk factors and clinical profile

Caputi, Maria Carmen January 1995 (has links)
No description available.
34

In-vivo and in-vitro investigations of HIV enteropathy

Fleming, Simon Charles January 1995 (has links)
No description available.
35

Origins and evolution of primate lentiviruses

Bailes, Elizabeth January 2001 (has links)
No description available.
36

Surveillance of HIV infection in Scotland

Allardice, Gwendolyn Muriel January 1996 (has links)
No description available.
37

Evaluation of the integration of the comprehensive care management and treatment plan for HIV and AIDS in Ekurhuleni and Sedibeng district health services

Maboe, Thoko Mercy 08 September 2015 (has links)
research report submitted to the School of Public Health, University of the Witwatersrand in partial fulfillment of the requirements for the degree of Master of Public Health. May 2015 / Introduction HIV and AIDS in South Africa has a considerable disease burden which places an enormous strain on the health care system. The increased workloads brought about by testing and counseling, prevention, treatment, care and support services with a concomitant decrease in the supply of health care workers impacts negatively on the quality of services. Health planners and managers need to implement approaches that enable maximum utilisation of available resources by integrating HIV and AIDS into the normal functioning of existing programmes to address increasing demands for HIV and AIDS services and to strengthen the health care system. Aim and Objectives The aim of the study was to describe the extent of integration of HIV and AIDS services at the different levels of care in the district health system. Method This is a descriptive cross sectional study that used structured pretested interview questionnaires, data review and a facility check list. A stratified random sample of five facilities that were accredited in the district from 2004 – 2007 was used. Fifty two interviews were conducted face to face with facility managers, doctors, nurses, dieticians, social workers, and lay counselors and seventeen self-administered questionnaires were completed by district programme managers. A total of 69 interviews were conducted. Results The study highlighted the fact that most of the facilities (96%) implemented the HIV and AIDS programme without a documented operational plan. Stakeholder participation on planning was limited at less than 30% across all levels of services within the district. Budgeting and resource allocation operated independently from the district and facility financial systems resulting in parallel systems. Technical support and programme reviews by the district and provincial managers were weak and irregular. Support of HIV and AIDS services was mainly given by facility management. The district`s monitoring and evaluation systems were not in place. The referral systems between the facilities and community structures were not well established. Lay counselors skills on PMTCT and nutrition was rated the lowest and compromised the implementation of an integrated approach. HIV and AIDS services were not implemented at well baby clinics. Conclusions The findings of this study suggests that the HIV and AIDS services have developed into separate vertical administrative and reporting systems operating differently from the mainstream services and not supporting the strengthening of the health care system and therefore not capable of achieving the intended goal of the programme.
38

Comparison of accuracy of HIV diagnosis between rapid HIV test kits conducted in non-laboratory settings and laboratory-based methods in South Africa

Chidarikire, Thato Nelly January 2016 (has links)
A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Doctor of Philosophy Johannesburg, 2016 / Introduction South Africa has the largest absolute number of individuals living with human immuno-deficiency virus (HIV) in the world. The quality assurance (QA) of HIV rapid diagnostic tests (RDT) has not kept pace with the rate of expanded testing and utilisation of RDT. This has made it difficult to assess the accuracy of testing. In South Africa HIV counselling and testing (HCT) and the use of HIV RDT is the point of entry to HIV prevention, management, care, treatment and support. HCT in public health facilities is delivered mainly through rapid testing by nonprofessional staff. Implementation of QA processes is crucial for accurate diagnosis of HIV. However, accuracy of HCT using rapid test kits in non-laboratory settings in South Africa will remain a challenge unless there is evidence that nonlaboratory rapid HIV testing results are as reliable as the laboratory-based enzyme immunoassays. This study aimed to determine the accuracy of HIV RDT in the context of an intervention. The objectives of the study were: i. To assess the sensitivity and specificity of rapid test kits in two provinces; ii. To assess the sensitivity and specificity of rapid test kits between the two provinces and New Start nongovernmental organisation (NGO) which implemented a more comprehensive quality management system (QMS); iii. To assess the accuracy of HIV RDT in the two provinces; iv. To assess the accuracy of HIV RDT between the two provinces and New Start sites. The hypothesis was ‘the accuracy of HIV diagnosis using HIV RDT kits in nonlaboratory settings in which an intervention has been introduced (internal quality control), also known as IQC, will not be different compared to settings that do not utilize IQC’. Methods In South Africa, the current laboratory-based gold standard for diagnosis of HIV infection in adults in the public sector as recommended by the National Health Laboratory Services (NHLS) Virology expert committee is a serial 2-test algorithm. Thus, a reactive enzyme immunoassay (EIA) test result must be confirmed by a second confirmatory EIA that must be different in terms of antigens and technology. The Expert Committee recommendation is that positive results should be confirmed by a separate sample 14 days later. In the case of HIV rapid testing the national HIV counselling and testing (HCT) policy, 2010, similarly recommends a serial 2-test algorithm for diagnosis where a reactive screening test is confirmed by a different confirmatory test. If the confirmatory test is reactive the diagnosis is positive. If test 1 is non-reactive then the diagnosis is negative. In case of discrepant results an enzyme-linked immunosorbent assay (ELISA) test was recommended as a tiebreaker. A new HIV testing services (HTS) policy was approved in South Africa in 2016 and it further recommended that the first time discrepant results are found, the counsellor must repeat the algorithm and if on repeat, the results are still discrepant, then reflex testing is recommended where the blood (whole blood) of a client is taken to the laboratory for ELISA (NDOH, 2016).This algorithm has replaced the use of Western Blot is South Africa. The rationale for the change was based on the sensitivity and specificity of 3rd and 4th generation ELISAs, workload, costs and expertise. With the introduction of the 3rd and latterly 4th generation EIA tests the above algorithm is in use in South Africa and has replaced the use of the Western blot as a confirmatory test. The rationale for the change is based on earlier detection of HIV infection, workload, costs and expertise. Further developments for a diagnostic algorithm include the use of a fourth generation test and if reactive to use a HIV-1 and HIV-2 discriminatory test and HIV viral load. This study was cross-sectional and compared the performance of HIV RDT in selected sites in Limpopo province that had introduced an intervention viz., an internal quality control (IQC) as part of quality management system (QMS) implementation, and compared to Mpumalanga province that had not introduced the IQC and performed limited QMS activities. The sample size calculated for the study was N = 717. IQC is an independent internal quality control that is used to check that an analytical phase or test precision is optimal. The introduction of routine QMS in Limpopo was through implementation of IQC supported by appropriate training and certification of implementers. IQC was implemented routinely as part of the provincial QA initiatives with the aim of supporting the implementation of HIV RDT in non- laboratory settings. There are other QA measures that may be implemented to support HIV RDT programmes including external quality assessment (EQA) such as proficiency testing (PT) which is a tool used to assess the testing process independently. EQA implementation was however not part of the Limpopo (LP) QMS implementation. Six high volume testing sites comprising of 3 hospitals and 3 clinics were selected per province. This was to avoid the risk of not meeting the required number of participants due to refusals, lack of results and challenges with reporting. In order to mitigate risk, the study was oversampled, where a total of 457 participants from the LP sites were enrolled in the study and results were analysed and compared to those of 361 participants from the Mpumalanga (MP) sites resulting in a total sample size of 818. The analyses included demographics, performance of RT as measured by the number of discordant results, reliability and validity of rapid tests RT as measured by the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) results. The data between Limpopo and Mpumalanga were further analysed together with the data from selected sites from a non-governmental organisation (NGO) called New Start and the performance, reliability and validity of the HIV test results were compared. The main role of New Start was to offer HCT in support of the government priorities and it implemented several different QMS measures for HIV rapid testing, namely, IQC, EQA, PT and re-testing, training for implementers, development and implementation of standard operating procedures (SOPs), and ensuring that all commodities were stored under appropriate conditions including temperature monitoring. In order to determine the validity and reliability of HIV RDT against the gold standard ELISA in Limpopo, Mpumalanga and New Start sites, the rate of discordance, the sensitivity, specificity, PPV and NPV were determined. Logistic regression models were constructed to assess the association between the interventions in the provinces. Crude and adjusted odds ratios were used as a measure of association between exposure and outcome and a 95% precision of estimate was used to ascertain statistical significance. Exposure factors with p<0.05 were considered statistically significant. Results A total of 947 attendees for HCT services in selected sites in Mpumalanga and Limpopo provinces between August and April 2012, were screened and of these, 818 were enrolled into the study according to the study inclusion criteria. There was no significant difference (p=0.05) between the number of participants enrolled in Limpopo (457) as compared to Mpumalanga (361) though Limpopo enrolled more participants than Mpumalanga. All available data from New Start sites for the period 2008 was analysed. The gender, rate of discordance and HIV positivity rate were significantly different between the two provinces (p<0.05). The study showed that the laboratory-based HIV prevalence rate in each setting was 22.9% in Limpopo, 26% in Mpumalanga and 11% in New Start sites. The prevalence rates reported by Shisana, 2014, were 21.8% for Mpumalanga and 13.9% for Limpopo. The rate of discordant HIV test results between the 2 provinces and New Start sites was also measured where discordant results were defined as those that were different between HIV rapid test and the ELISA test. The rate of discordant HIV test results was 5.9% (27) in Limpopo, 11.0% (40) in Mpumalanga p= 0.010 and 1.4% (68) in New Start sites. False negative results accounted for all the discordant results. Logistic regression models were used to estimate the Odds Ratio (OR) and the 95% confidence interval of the association between implementation of QA programme and the HIV test accuracy or the HIV discordance rate. Facilities without a QA intervention programme had an approximately 2-fold increased odds of HIV test discordance compared to facilities with a QA programme in place (crude OR 1.86, 95% CI: 1.10 – 3.12 and adjusted OR 1.90, 95% CI:1.08 - 3.30). This association was statistically significant. The sex and age of the participants was not associated with discordance rate. The sensitivities of the HIV RDT in Limpopo, Mpumalanga and New Start sites were 86% (CI: 83.9-89.4), 72% (CI: 64.2-79.0) and 98% (CI: 97.6-98.4) respectively. In this study, specificity ranged within 99% (CI: 98.9-99.9) in all sites (Provinces and New Start sites). The PPV in Limpopo, Mpumalanga and New Start sites were 98% (CI: 93.2-99.6), 97% (CI: 91.0-99.2) and 93% (CI: 92.3-93.7) respectively, The NPV results in Limpopo were 93% (90.5-95.2), Mpumalanga at 86% (CI:81.3-90.7). For New Start sites, the NPV was 99.6% (CI: 99.4-99.8). The sensitivities and specificities of the sites were used at a national prevalence rate of 18.8% to determine the national PPV and NPV and these were found to be 100% (CI: 100-100) and 91.3% (CI: 89.04-92.96) respectively. Discussion In all three settings the World health Organisation (WHO) recommended sensitivity (>99%) and specificity (>98%) were not met. There was a gradient of sensitivities and specificities that was associated with the extent of QA implementation. Thus, New Start sites with a more extensive set of QA activities had the highest sensitivity; LP with introduction of IQC, had an intermediate sensitivity and MP the lowest. Despite the introduction of an intervention LP was not able to meet the required level of QA implementation compared to New Start. Increased discordance was associated with the extent of implementation of QA as shown by the results of the logistic regression model (crude and adjusted). In this study there was a decline in sensitivity that resulted in some false negative results. To a lesser extent, some false positive results were also identified in New Start sites. In the case of LP and MP the potential contributory factors to false negative results xi would include the extent of QA implementation and training. Further evidence of the relative poor implementation would include the M&E assessments and in the course of the study there lost results, poorly taken and missing specimens that led to data being excluded. Conclusion On the basis of these results, it is concluded that implementation of quality assurance measures is critical to ensure correct diagnosis of rapid HIV testing. Furthermore, implementation of a combination of aspects of QA is urgently required including training of all implementing staff on quality assurance of rapid HIV testing, monitoring and evaluation to assess kit performance through IQC and PT, as well as implementation of the current South African HIV testing Services (HTS) Policy. All PT methods should be explored for implementation and training and certification of implementers must be ensured. / MT2017
39

Estudo evolutivo das crianças expostas ao HIV e notificadas pelo núcleo de vigilância epidemiológica do HCFMRP-USP / Evolutive study of children exposed to HIV and notified by the Nucleus of Epidemiological Surveillance of HCFMRP-USP

Silva, Adriana Nunes Fernandes da 23 December 2004 (has links)
Esta pesquisa teve como objetivo avaliar a evolução de crianças nascidas de mães positivas para o HIV ou com AIDS no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, durante o período compreendido entre 1986 e 2001. Foram levantadas informações relativas a profilaxia pré-natal e da criança ao nascer, assim como à reversão sorológica, soropositividade e sobrevida. Dos 680 participantes, 67 (9,8%) se infectaram, 520 (76,5%) não se infectaram e 93 (13,7%) ficaram sem informação devido ao abandono de seguimento. Profilaxia durante a gestação ocorreu em 144 mulheres com o uso de uma droga (21,2%) e em 77 com a utilização de duas ou mais drogas (11,3%), não tendo se verificado em 459 gestantes (67,5%). Entre os recém nascidos, 205 (30,1%) receberam apenas AZT, 134 (19,7%) foram medicados com AZT+SMX/TMP e 341 (50,1%) não foram tratados. Ocorreu óbito de 39 crianças (5,7%), com 559 (82,2%) tendo permanecido vivas e 82 (12,0%) cuja informação foi perdida. O percentual de óbito foi consideravelmente mais elevado entre os que não receberam profilaxia (9,7%), em relação aos que receberam apenas AZT (2,9%). Não se verificou nenhuma morte entre as 134 crianças em uso AZT+SMX/TMP. As proporções de óbitos variaram de acordo com o tempo, atingindo 9,5% no período pré-profilaxia (1986/1995) e caindo para 2,7% entre os anos de 1996 e 2001. Entre os 67 indivíduos infectados pelo HIV foram verificadas 22 mortes (33,8%), valor muito superior ao encontrado entre os 520 não infectados, nos quais ocorreram apenas 4 óbitos (0,8%). Os tempos medianos de reversão sorológica foram iguais a 589 dias para os nascidos de 1986 a 1995, e 451 dias, para os que nasceram no período 1996 a 2001. As curvas de sobrevivência demonstraram o evidente favorecimento dos indivíduos que foram submetidos a algum tipo de profilaxia, indicando que a intervenção terapêutica trouxe ganhos inquestionáveis para os recém nascidos de gestantes positivas para o HIV ou com AIDS. / The objective of the present study was to evaluate the evolution of children born to HIV-positive mothers or mothers with AIDS at the University Hospital, Faculty of Medicine of Ribeirão Preto, during the period from 1986 to 2001. Information was obtained about prenatal prophylaxis and infant prophylaxis at birth, and about serologic reversal, seropositivity and survival. Of the 680 participants, 67 (9.8%) were infected, 520 (76.5%) were not infected, and no information was available for 93 (13.7%) infants who were lost to follow-up. Prophylaxis during pregnancy occurred in 144 women with the use of mono prophylaxis (21.2%) and in 77 with the use of two or more drugs (11.3%), and 459 (67.5%) received no prophylaxis. Among the newborns, 205 (30.1%) received only AZT, 134 (19.7%) were medicated with AZT+SMX/TMP, and 341 (50.1%) had not carried trough prophylaxis. Thirty-nine children died (5.7%), 559 (82.2%) continued to live, and for 82 (120%) the information was lost. The death rate was considerably more elevated among the children who did not receive prophylaxis (9.7%) compared to those who received only AZT (2.9%). No death occurred among the 134 children had prophylaxis with AZT+SMX/TMP. Death rates varied according to time, reaching 9.5% during the preprophylaxis period (1986/1995) and falling to 2.7% between 1996 and 2001 Twenty-two deaths occurred among the 67 HIV-infected individuals (33.8%), a much higher value than detected among the 520 non-infected individuals (4 deaths, 0.8%). The median times for serological reversal were 589 days for the infants born between 1986 and 1995 and 451 days for those born from 1996 to 2001. The survival curves demonstrated an evident favoring of individuals submitted to some type of prophylaxis, indicating that therapeutic intervention has brought unquestionable gains for infants born to HIV-positive mothers or mothers with AIDS.
40

Estudo evolutivo das crianças expostas ao HIV e notificadas pelo núcleo de vigilância epidemiológica do HCFMRP-USP / Evolutive study of children exposed to HIV and notified by the Nucleus of Epidemiological Surveillance of HCFMRP-USP

Adriana Nunes Fernandes da Silva 23 December 2004 (has links)
Esta pesquisa teve como objetivo avaliar a evolução de crianças nascidas de mães positivas para o HIV ou com AIDS no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, durante o período compreendido entre 1986 e 2001. Foram levantadas informações relativas a profilaxia pré-natal e da criança ao nascer, assim como à reversão sorológica, soropositividade e sobrevida. Dos 680 participantes, 67 (9,8%) se infectaram, 520 (76,5%) não se infectaram e 93 (13,7%) ficaram sem informação devido ao abandono de seguimento. Profilaxia durante a gestação ocorreu em 144 mulheres com o uso de uma droga (21,2%) e em 77 com a utilização de duas ou mais drogas (11,3%), não tendo se verificado em 459 gestantes (67,5%). Entre os recém nascidos, 205 (30,1%) receberam apenas AZT, 134 (19,7%) foram medicados com AZT+SMX/TMP e 341 (50,1%) não foram tratados. Ocorreu óbito de 39 crianças (5,7%), com 559 (82,2%) tendo permanecido vivas e 82 (12,0%) cuja informação foi perdida. O percentual de óbito foi consideravelmente mais elevado entre os que não receberam profilaxia (9,7%), em relação aos que receberam apenas AZT (2,9%). Não se verificou nenhuma morte entre as 134 crianças em uso AZT+SMX/TMP. As proporções de óbitos variaram de acordo com o tempo, atingindo 9,5% no período pré-profilaxia (1986/1995) e caindo para 2,7% entre os anos de 1996 e 2001. Entre os 67 indivíduos infectados pelo HIV foram verificadas 22 mortes (33,8%), valor muito superior ao encontrado entre os 520 não infectados, nos quais ocorreram apenas 4 óbitos (0,8%). Os tempos medianos de reversão sorológica foram iguais a 589 dias para os nascidos de 1986 a 1995, e 451 dias, para os que nasceram no período 1996 a 2001. As curvas de sobrevivência demonstraram o evidente favorecimento dos indivíduos que foram submetidos a algum tipo de profilaxia, indicando que a intervenção terapêutica trouxe ganhos inquestionáveis para os recém nascidos de gestantes positivas para o HIV ou com AIDS. / The objective of the present study was to evaluate the evolution of children born to HIV-positive mothers or mothers with AIDS at the University Hospital, Faculty of Medicine of Ribeirão Preto, during the period from 1986 to 2001. Information was obtained about prenatal prophylaxis and infant prophylaxis at birth, and about serologic reversal, seropositivity and survival. Of the 680 participants, 67 (9.8%) were infected, 520 (76.5%) were not infected, and no information was available for 93 (13.7%) infants who were lost to follow-up. Prophylaxis during pregnancy occurred in 144 women with the use of mono prophylaxis (21.2%) and in 77 with the use of two or more drugs (11.3%), and 459 (67.5%) received no prophylaxis. Among the newborns, 205 (30.1%) received only AZT, 134 (19.7%) were medicated with AZT+SMX/TMP, and 341 (50.1%) had not carried trough prophylaxis. Thirty-nine children died (5.7%), 559 (82.2%) continued to live, and for 82 (120%) the information was lost. The death rate was considerably more elevated among the children who did not receive prophylaxis (9.7%) compared to those who received only AZT (2.9%). No death occurred among the 134 children had prophylaxis with AZT+SMX/TMP. Death rates varied according to time, reaching 9.5% during the preprophylaxis period (1986/1995) and falling to 2.7% between 1996 and 2001 Twenty-two deaths occurred among the 67 HIV-infected individuals (33.8%), a much higher value than detected among the 520 non-infected individuals (4 deaths, 0.8%). The median times for serological reversal were 589 days for the infants born between 1986 and 1995 and 451 days for those born from 1996 to 2001. The survival curves demonstrated an evident favoring of individuals submitted to some type of prophylaxis, indicating that therapeutic intervention has brought unquestionable gains for infants born to HIV-positive mothers or mothers with AIDS.

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