Thesis (D. Min.)--Temple Baptist Seminary, 1999. / Abstract. Includes bibliographical references (leaves 174-177).

Dissertation (M.Mus. (Music Therapy))-University of Pretoria, 2007. / Abstract in Afrikaans and English. Includes bibliographical references.

Dissertation (M.Mus. (Music Therapy))-University of Pretoria, 2003. / Abstract in Afrikaans and English. Includes bibliographical references. Available on the Internet via the World Wide Web.

Made available in DSpace on 2014-08-13T14:50:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-27Bitstream added on 2014-08-13T17:59:57Z : No. of bitstreams: 1 000768414_20150227.pdf: 405027 bytes, checksum: 6e706557e5d0de7bdf064cbc7b902964 (MD5) Bitstreams deleted on 2015-03-03T12:45:18Z: 000768414_20150227.pdf,Bitstream added on 2015-03-03T12:45:55Z : No. of bitstreams: 1 000768414.pdf: 678249 bytes, checksum: f0428b1ea997431e198449d539145f7d (MD5) / Apesar dos grandes avanços que conduziram a um declínio da infecção pelo HIV em crianças, a terapêutica antirretroviral vem sendo limitada pela emergência de resistência. Neste contexto, a finalidade deste estudo foi avaliar o perfil de mutações e resistência aos inibidores de transcriptase reversa análogos de nucleosídeos (ITRN) e não análogos de nucleosídeos (ITRNN) protease (IP) das variantes virais circulantes em pacientes pediátricos atendidos no Ambulatório de Imunologia Pediátrica da Faculdade de Medicina de Botucatu, UNESP. Foram avaliados dezenove pacientes, sendo dezesseis com falha terapêutica e, três virgens de tratamento. RNA viral plasmático foi utilizado como fonte para genotipagem das regiões genômicas da transcriptase reversa (TR) e protease (PR) do HIV. Os resultados demonstraram prevalência do subtipo B (78,95%). As mutações de resistência aos ITRNs encontradas em maior frequência foram L214F (73,7%), M184V (42,1%), R211K (42,1%), M41L (31,5%), T215Y (31,5%), L210W (21%), V118I (21%). As mutações K103N e Y188L encontradas em 26,3% e 10,5% dos pacientes foram as mais freqüentes entre as mutações associadas ao uso dos ITRNNs. Quanto aos IPs as mutações mais frequentes foram M36I (63,1%), L63P (52,6%), E35D (47,3%), R41K (31,5%), I13V (31,5%), M46V (26,3%), L90M (26,3%), I93L (26,3%), V77I (26,3%), V82A (21,1%), I54V (21,1%). No que se relaciona ao perfil de resistência, 3TC, AZT, EFV e NVP foram os ITR com menor potencial de uso devido à resistência. Já os IPs apresentam grande potencial de utilização na população estudada, o que se justifica pela alta barreira genética destes medicamentos. Dos três pacientes não tratados, um apresentava resistência a EFV e NVP, sugerindo ocorrência de resistência transmitida. Novos estudos devem ser conduzidos a fim de avaliar o real significado destes achados / Although great progresses lead a decline of the HIV infection in children, the antiretroviral therapy has found obstacles as the resistance emergency. In this context the goal of this study was evaluate to the profile of mutations and genotypic resistance to the Nucleoside Reverse Transcriptase Inhibitors (NRTI), Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI) and Protease Inhibitors (PI) in children assisted in the Pediatric Immunology Ambulatory, Botucatu School of Medicine. Patients (19) were evaluated (16 with therapeutic failure and 3 naïve). Viral RNA was used as source to RT and PR genomic regions genotyping. Subtype B was the most frequent (78.95%) in thi study. The NRTI resistance mutations found were L214F (73.7%), M184V (42.1%), R211K (42.1%), M41L (31.5%), T215Y (31.5%), L210W (21%), V118I (21%). K103N and Y188L were found in 26.3% e 10.5% and we are associated with NNRTI use. About the PI the mutations most frequent were M36I (63.1%), L63P (52.6%), E35D (47.3%), R41K (31.5%), I13V (31.5%), M46V (26.3%), L90M (26.3%), I93L (26.3%), V77I (26.3%), V82A (21.1%), I54V (21.1%). The ARVs resistance analysis showed that 3TC, AZT, EFV and NVP have the lower potential for use due to resistance. PI presented great potential for use due to high genetic barrier. From three naïve patients one presented resistant viral variants to EFV and NVP, suggesting transmitted resistance. New studies should be performed to evaluate these findings

Thesis (MTech (Nursing))--Cape Peninsula University of Technology, 2009. / By the end of 2007 an estimated 22 million people in sub-Saharan Africa were living with HIV/AIDS. Of these, 1.8 million (33%) were children under the age of 15 years. The epidemic has left 11.6 million children orphaned by AIDS. Zimbabwe has an estimated population of 12 million people; its HIV infection rate amongst all adults was estimated at 33.7% in 2002, decreased to 15.1% in 2007: most likely due to extensive prevention campaigns that were held by the Ministry of Health and Child Welfare, in partnership with other stakeholders. Despite the decrease in infection rate, 1.3 million people live with the HIV/AIDS and 140 000 have died. United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organisation (WHO) (2008) reported that of the 1.3 million people 120 000 were children and 1 million children had been orphaned due to AIDS in Zimbabwe. Only 3% of children living with HIV/AIDS were on anti-retroviral therapy (ART) due to lack of antiretroviral (ARV) paediatric formulations drugs. The purpose of the study is to determine what palliative care services are available for children diagnosed with AIDS in Harare, Zimbabwe and whether the services provided meet the palliative care needs of the children. The aims of the study are to: describe the palliative care services offered by the public health sector to children diagnosed with AIDS; describe the extent of palliative care services offered by NGOs sector to children diagnosed with AIDS; describe what children diagnosed with AIDS perceive as their care needs; and to compare the needs of the children with the services provided.

M.Ed. (Educational Psychology) / Please refer to full text to view abstract

This study is an exploratory investigation aimed at understanding the intrapsychic themes of children affected by HIV/AIDS, using the medium of the Sceno test. The Sceno test is a play assessment technique. The aim of this research was to ascertain if the Sceno test would be a useful procedure to increase our understanding of children's intrapsychic experience of illness, impending death, and/or the death of their parents. Four children, between the ages of 7 - 11, who are affected by HIV/AIDS and are living in a children's home, were assessed three times. Two children not affected by HIV/AIDS but who had lost their parents were also included in the study. The assessment sessions were videotaped and then the action and dialogue transcribed. A hermeneutic phenomenological methodology was used within a narrative framework to interpret the 'text' of the children's play. Several important themes arose in analysis. Children were concerned with routines, particularly within the family. This is believed to be demonstration of a need for security and structure. The role of the Mother as caring and nurturing occurred often in the childrens' play. This demonstrates attachment or wish for attachment to this figure. Other important themes were those of organising the environment and having control over the context of the play, and the theme of the doctor and illness. The Sceno was found to be a valuable means of eliciting the intrapsychic themes of these children. Limitations and implications of the study are considered. / Thesis (M.A.)-University of Natal, Pietermaritzburg, 2001.

This study sought to explore the views of healthcare workers regarding paediatric anti-retroviral therapy (ART) adherence in Nigeria. An exploratory descriptive qualitative research design was used to identify and describe healthcare workers’ views in Kano and Lagos, Nigeria. Three focus group discussions were held. The transcribed data was analysed using the framework approach of data analysis. Healthcare providers perceived poverty, illiteracy, stigma and discrimination, inappropriate care approaches, and parental dynamics as factors influencing ART adherence. Recommendations for enhancing paediatric ART adherence levels in Nigeria included: mainstreaming adherence counselling in paediatric ART and adopting a comprehensive family centred care approach were identified as measures for improving paediatric ART adherence. Other measures included free ART services, quality improvement in paediatric ART services, parental empowerment and stigma and discrimination reduction programmes. / Health Studies / M.A. (Public Health)

The HIV/AIDS pandemic has implications at every level of social functioning. It affects individuals, families, communities and organisations. The burden of caring for those exposed, affected and infected is vast, but one of the most significant developments which have the potential to reduce disease burden is antiretroviral therapy. Antiretroviral therapy (ART) is complex and difficult to administer, and requires a learning process which is mediated through a number of means. Vygotskian theory was utilised to better understand the process of adherence through mediated learning, and as a framework for explaining compliance. In this study, mediated learning occurs both in the context of the clinic staff and the clinic attendees, and the caregivers and the child. Therefore Vygotsky‟s theory offers useful insight into this process. This qualitative study aimed to research the factors which contribute to ART adherence in a small sample of HIV positive children who are attending a local clinic. Eight child-caregiver dyads were interviewed, and drawings utilised to better understand child and caregiver factors which contribute to compliance. There were a number of psychosocial factors identified which contribute to compliance, or lack thereof, including social support, stigma, medication fatigue, disclosure, access difficulties, psychoeducation, and motivation. A number of qualitative differences were also identified between children who knew their HIV status and those who did not. These differences emerged primarily through the analysis of the child participants‟ drawings and there appeared to be a number of inter- and intrapersonal benefits to disclosure. The factors identified in this study, if better understood, can inform interventions to improve compliance on ART. / Thesis (M.Soc.Sci.)-University of KwaZulu-Natal, Pietermaritzburg, 2010.

This qualitative study is an exploration of the sexual subjectivities of a group of Coloured high school girls aged 16-17. These girls emerge from both working and middle class backgrounds in the former Coloured suburb of Sydenham in Durban. The study sought to understand what the Coloured girls in this study regard as risky sexual behaviour, what types of risky sexual behaviours they engage in, as well as how they both accommodate and resist male power, with regard to their sexual attitudes and practices. Gender-power and poststructuralist theories were used to show how gender and (male) power are implicated in sexual risk. The findings show that these Coloured girls accommodate, challenge and resist persisting gender norms, traditional sex roles and racial stereotypes. Focus group and individual interviewing techniques elicited responses that show the variegated sexual identities and evidence of sexual agency crafted in their attempts to assert themselves as young women who are able to subvert discourses of male sexual privilege and power. The findings also illuminate how many of the girls in this study demonstrate a certain amount of agency, where they are able to negotiate safe sex practices with their partners. Such resistance and agency has important implications for sexual decision making and girls’ empowerment. Findings of this study were used to develop strategies in order to raise greater HIV and AIDS awareness, encourage safer sex practices as well as build more caring, loving and cohesive relationships. / Thesis (M.Ed.)-University of KwaZulu-Natal, Durban, 2012.