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Metabolický syndrom a steroidní spektrum / Metabolic syndrome and steroid spectrumPospíšilová, Hana January 2014 (has links)
Sex steroids influence the storing of fat, and differences in the distribution of fat are a typical secondary sexual characteristic. Androgens act on fatty tissues in males either directly through stimulation of the androgen receptor or indirectly through aromatization of the estrogen receptor. Androgens can be classified as aromatizable or non-aromatizable. Testosterone (T) is the main aromatizable androgen, while its metabolite dihydrotestosterone (DHT) is a non-aromatizable androgen that acts only through the androgen receptor. It is precisely this difference in having activity only through the androgen receptor that has given rise to the hypothesis concerning the differing effects of DHT and T on body composition, with DHT possibly being responsible for male-type fat distribution. As part of my post-graduate studies we analyzed the dependence serum levels of T and DHT on age, as well as changes in their ratio with age. Further, we sought relationships between aromatizable and non-aromatizable androgens and metabolic and anthropometric parameters. We also focused on following any changes in steroidogenesis in obese males. We showed that before puberty the dominant androgen is rather DHT than T, that the fDHT/fT ratio during the life of adult males is constant, and that there is no evidence of a reversal...
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Sex Steroids and the Effect of In-utero Altrenogest Exposure in Neonatal FoalsSwink, Jacob Maxwell 30 December 2020 (has links)
No description available.
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Functional analysis of the human androgen receptor using synthetic and naturally occurring mutationsKazemi-Esfarjani, Parsa. January 1996 (has links)
No description available.
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Analysis of two point mutations in the androgen receptor gene of patients with complete androgen resistanceBordet, Sylvie January 1992 (has links)
No description available.
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Structure-function analysis of three widely dispersed point mutations in the hormone-binding domain of the human androgen receptorSabbaghian, Nelly January 1994 (has links)
No description available.
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Molecular genetic analysis of receptor-defective androgen resistance in manPrior, Lynn January 1989 (has links)
No description available.
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Cytochrome c oxidase subunit Vb interacts with human androgen receptor : a potential mechanism for neuronotoxicity in spinobulbar muscular atrophyBeauchemin, Annie January 2000 (has links)
No description available.
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Analysis of exon 1 and the 5'-flanking region of the androgen receptor gene in subjects with androgen insensitivity syndromeVasiliou, Denise Marie. January 1996 (has links)
No description available.
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Characterization of four point mutations in the androgen receptor gene of subjects with varying degrees of androgen insensitivity syndromeShkolny, Dana January 1995 (has links)
No description available.
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The CD4+ T cell response to CNS viral infectionLin, Adora A. 17 April 2009 (has links)
No description available.
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