Global ETD Search

171	Role of C-erB-4/HER4 and the alternatively spliced extracellular domain isoform of the c-erB-3/HER3 growth factor receptor in normal tissues and in cancer Srinivasan, Radhika January 1999 (has links) No description available. 572
172	Molecular analysis of antigenic variation in fusion glycoprotein of respiratory syncytial virus Conor, Alyson Lloyd January 1998 (has links) No description available. 572.8
173	Aspects of the detection and discrimination of members of the fungal genus Pythium by serological and molecular methods Petch, Geoffrey Michael January 1999 (has links) No description available. 630
174	Changes in the microflora and humoral immune response following periodontal therapy Darby, Ivan B. January 1999 (has links) No description available. 610
175	Studies on tobacco yellow dwarf virus, a geminivirus of the genus Mastrevirus adapted to dicots : infectivity determinants, virion sense gene expression and ribosome inactivatin protein-based resistance Papadopoulou, Eugenia January 2000 (has links) No description available. 579
176	Emulsion formulations as delivery systems for soluble protein subunit viral vaccines Peagram, Rebecca Elizabeth January 1997 (has links) No description available. 615.1
177	Characterisation of the oligopeptide permease of Escherichia coli De Ugarte Berthoumieux, Maria Alicia January 1997 (has links) No description available. 572
178	Immunochemical studies on fibroblast growth factor-1 and fibroblast growth factor receptor 1 Walters, Jean E. January 1998 (has links) No description available. 610
179	Modulation of the PD-1 pathway by inhibitory antibody superagonists Akkaya, Billur January 2012 (has links) In metozoans, most of the key events that lead to cell activation and inhibition are controlled by tyrosine phosphorylation. Extracellular signals are transmitted by membrane bound receptors, which have intrinsic kinase activity or themselves recruit intracellular kinases to specialised inhibitory or activating phosphorylation motifs. In this way, the pattern of kinase activation creates its own turnover and can rapidly generate amplified signals by positive feedback, or recruit inhibitory proteins to counteract the signals. This process of inhibition is also constitutive since it requires continuous counter-inhibition by phosphatases at the cell surface and intracellularly even in the absence of ligands. The absence of phosphatase activity results in unbridled protein phosphorylation and form this and other data it has been proposed that the triggering of the T cell receptor and other co-receptors may result simply by physical exclusion of the large phosphatases such as CD45 from the vicinity of the receptors. Superagonist monoclonal antibodies may work in a similar way, by binding receptors close to the plasma membrane and excluding extracellular phosphatases. The work described in this thesis seeks to discover if antibody superagonists can be generated against the T cell inhibitory cell surface receptor PD-1 and test if this approach can attenuate the immune response. Using in vitro assays of lymphocyte activation and a mouse model expressing human PD-1, this study characterises a series of anti-PD-1 antibodies and shows how patterns of inhibitory activity varying according to binding sites. The inhibitory effects of the anti-PD1 antibodies are seen in the humoral, cellular and transplant immune responses. Agonistic anti-PD1 antibodies induce regulatory T cells and may have role in suppression of autoimmune disease. The thesis suggests that superagonism may be harnessed clinically to dampen the immune response, through activation of inhibitory receptors. 616.0798
180	Isolation and characterisation of hTNF-alpha neutralising VNARs from an immunised nurse shark, Ginglymostoma cirratum, using phage display Ubah, Obinna Chukwuemeka January 2016 (has links) No description available.

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