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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 661 to 670 of 1467 (0.012 seconds)| 661 |
A Parametric Study to Quantify the Pressure Drop of Pulsating Flow through BlockagesPappu, Suryanarayana 13 October 2014 (has links)
No description available.
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| 662 |
Diagnosis of Coronary Artery Disease Using Pressure Drop CoefficientKolli, Kranthi Kumar January 2014 (has links)
No description available.
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| 663 |
Effects of Prior Aerobic Exercise on Vascular Dysfunction Induced by Prolonged Sitting in Healthy MenDuguid, Robert M. 25 April 2017 (has links)
No description available.
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| 664 |
COUPLED OXYGEN TRANSPORT ANALYSIS IN THE AVASCULAR WALL OF A CORONARY ARTERY STENOSIS DURING ANGIOPLASTYVAIDYA, VINAYAK S. 27 September 2005 (has links)
No description available.
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| 665 |
Youth with Obesity and Obesity-Related Type 2 Diabetes Demonstrate Abnormalities in Carotid Structure and FunctionUrbina, Elaine M. January 2009 (has links)
No description available.
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| 666 |
Design of Experimental Facility to Simulate Pulsating Flow Through a BlockageMindel, Scott A. 20 September 2011 (has links)
No description available.
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| 667 |
Addressing the Missing Heritability of Coronary Artery DiseaseHartmann, Katherine Louise Seal, Hartmann January 2016 (has links)
No description available.
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| 668 |
DETECTION AND QUANTIFICATION OF CORONARY CALCIUM FROMDUAL ENERGY CHEST X-RAYS: PHANTOM FEASIBILITY STUDYZhou, Bo January 2016 (has links)
No description available.
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| 669 |
The Effect of Exercise on Endothelial Function in Postprandial LipemiaThompson, Benjamin Charles January 2008 (has links)
No description available.
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| 670 |
BIOTECHNOLOGICAL INVENTION OF CALOXINS - A NOVEL CLASS OF ALLOSTERIC INHIBITORS SPECIFIC FOR PLASMA MEMBRANE CALCIUM PUMP ISOFORMSSzewczyk, Maria Magdalena 10 1900 (has links)
<p>This work used biotechnology to invent new caloxins - allosteric peptide inhibitors of plasma membrane Ca<sup>2+ </sup>pumps (PMCA) needed to understand the Ca<sup>2+ </sup>signalling in coronary artery.</p> <p>PMCA are encoded by genes PMCA1-4. Defects in PMCA expression have been associated with several pathologies. The major objectives of my thesis were to determine the expression of PMCA isoforms in the smooth muscle and the endothelium of coronary artery and to invent high affinity and specificity caloxins for the isoforms present in these tissues.</p> <p>In Aim 1 it was determined that the total PMCA protein and activity was much greater in smooth muscle than in endothelium. Both tissues expressed only PMCA1 and PMCA4, with PMCA4 > PMCA1 in smooth muscle and PMCA1 > PMCA4 in endothelium. Therefore, the search for PMCA1 and 4 selective caloxins using phage display technique was conducted.</p> <p>Aim 2 was to invent PMCA1 selective inhibitors. Caloxin 1b3 was invented as the first known PMCA1 selective inhibitor. It inhibited PMCA1 Ca<sup>2+</sup>-Mg<sup>2+</sup>-ATPase with higher affinity than PMCA2, 3 or 4. Aims 1 and 2 were consistent with the greater potency of caloxin 1b3 than a known PMCA4 selective caloxin 1b1 in increasing cytosolic Ca<sup>2+</sup> concentration in endothelial cells.</p> <p>Aim 3 was to obtain ultrahigh selectivity and affinity PMCA4 bidentate inhibitor using the previously invented PMCA4 selective caloxins 1c2 and 1b2. In the first step the affinity of caloxin 1b2 was improved by limited mutagenesis to obtain caloxin 1c4. Caloxin 1c4 had 5-6 times higher affinity than caloxin 1b2 for inhibiting PMCA4 activity. Optimization of the bidentate caloxins from caloxin 1c2 and 1c4 was also attempted.</p> <p>The novel caloxins may aid in elucidating the role of PMCA1 and PMCA4 in the physiology and pathophysiology of coronary artery and other tissues.</p> / Doctor of Philosophy (PhD)
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