No description available.

No description available.

To find a relationship between moment versus curvature in a traction-free ovine artery, a pure moment was applied to a radially cut ovine artery (length 50.23 mm). The curvature of the segment opposite the cut was calculated and used to calculate the pre-stresses using a Fung type model. The pre-stresses were then used to calculate the moment. The moment applied during the experiment was calculated by recording the twist applied and the stiffness of the wire applying the moment. The artery was sutured symmetrically with a custom jig, and then sutured to two blocks, one fixed and one subject to the pure moment. The axial strain was assumed unity. The Fung model yielded a linear moment versus curvature relationship, as well as the moment versus curvature relationship for the experiment. Despite both small and large stretches, the strains felt by the artery were not influential enough to display a non-linear correlation for moment vs curvature.

Thesis (Ph. D.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 93-120).

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 105-114).

Thesis (M.S.)--Florida State University, 2004. / Advisor: Dr. Laurie Grubbs, Florida State University, School of Nursing. Title and description from dissertation home page (viewed June 16, 2004). Includes bibliographical references.

Thesis (Ph.D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Physiology. Title from title-page of electronic thesis. Bibliography: leaves 94-110.

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Background: Coronary artery calcification (CAC) is common in chronic kidney disease (CKD) patients, and is demonstrable in fifty percent of incident dialysis patients. Therefore, the process of CAC initiation likely occurs in the pre-dialysis period. Pre-dialysis CKD patients have been shown to have a substantially higher burden of CAC than age and sex matched controls from the general population. Consequently, the hypothesis that CKD itself is a risk factor for CAC occurrence is biologically plausible. Objective: 1) To quantify the relationship between CKD and CAC in stage three to five CKD patients without known cardiovascular disease. 2) To estimate the strengths of associations between traditional cardiovascular disease risk factors, non- traditional cardiovascular disease risk factors and CAC in this patient population. Methods: This cross-sectional study investigated one hundred and nineteen CKD patients (excluding dialysis) receiving care at a single hospital in Kingston, Ontario, Canada. For the primary objective, correlational analyses were performed to evaluate associations between a priori selected variables of kidney function and CAC scores, as well as other a priori chosen variables of interest. Results: Mean and median CAC scores were 566.5 SD: 1108 and 111 (inter-quartile range 2 to 631.5) respectively. CAC correlated with age (r = 0.44, p<0.001), body mass index (r = 0.28, p = 0.002), high density lipoprotein cholesterol (r = -0.23, p = 0.01), diabetes mellitus (r = 0.23, p = 0.01), and the cardiovascular risk score (r = 0.35; p < 0.001). By multivariable linear regression controlling for eGFR and diabetes, age (ß = 0.05, 95% CI 0.03-0.06; p<0.001), body mass index (ß = 0.04, 0.02 - 0.07; p=0.001), and serum calcium (ß = 0.9, 0.15 - 1.6; p=0.02), were risk factors for CAC. Results from multivariable logistic regression modeling demonstrated consistent findings. Limitations: Inadequate sample size and uncontrolled confounding are possible limitations, but are unlikely to have changed the main study findings. Conclusions: In this study, traditional cardiovascular disease risk factors and serum calcium were associated with coronary artery calcification. No association was demonstrated between CKD and CAC. Studies exploring potential protective mechanisms against coronary artery calcification are needed.

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