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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Abdominal symptoms and anorectal function in outpatients with the irritable bowel syndrome (IBS) /

Gudmundur Ragnarsson. January 1900 (has links) (PDF)
Diss. (sammanfattning) Linköping : Univ. / Härtill 5 uppsatser.
2

Helicobacter pylori infection among children in Sweden /

Tindberg, Ylva, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.
3

The role of voltage-gated sodium channel 1.9 (Nav1.9) in visceral afferent signalling

Boundouki, George January 2013 (has links)
Abdominal pain places a large burden on society and its current management is sub-optimal due to the lack of visceral-specific analgesics. Voltage-gated sodium channels (Nav) are crucial for action potential generation and Nav1.9 has the lowest activation threshold of all these channels. In addition, Nav1.9 expresses a unique, slow, persistent current and is peripherally expressed on small diameter dorsal root ganglion (DRG) neurons. Whereas, at the level of the DRG, the Nav1.9 current is enhanced in response to a number of inflammatory mediators, no data exist for the role of Nav1.9 in signalling at the nerve terminal. Behavioural studies in mice have established a role for Nav1.9 in the response of somatic afferents to inflammatory mediators where it has a role in the immediate response of the afferents as well as in the development of hyperalgesia. No studies have investigated the role of Nav1.9 in the response of visceral afferents to inflammatory and mechanical stimuli. This thesis investigated the role of Nav1.9 in the response of visceral afferents to a variety of chemical and mechanical stimuli. Electrophysiological recording of colonic and intestinal afferents from Nav1.9 wild type and knockout mice were made using a bespoke recording chamber. The tissue was superfused with a number of chemical mediators and the change in peak afferent activity compared between wild type and knockout mice. For some experiments, human inflammatory supernatant was generated from inflamed and control appendices. The effect of this supernatant on visceral afferents and the role of Nav1.9 in this response were studied. The response of visceral afferents to intraluminal distension was also studied in Nav1.9 wild type and knockout mice. The data presented in this thesis demonstrate a pivotal role for Nav1.9 in the activation of visceral afferents by chemical and mechanical stimuli as well as a human inflammatory supernatant. The response of colonic and intestinal afferents to bradykinin, capsaicin and intraluminal distension is significantly attenuated in Nav1.9 knockout mice. Although the peak response of afferents to acetic acid was not significantly different between the genotypes, there were significant differences in the profile of the responses. Additionally, the data show that cyclooxygenase blockade enhances the effect of elimination of Nav1.9 on the response of afferents to noxious stimuli. Finally, the activation of visceral afferents by human inflammatory supernatants was significantly decreased in Nav1.9 knockout mice suggesting that blockade of this channel in man could provide analgesic effects that, due to its restricted peripheral distribution, would not be expected to be associated with the side effect profile of the current non-specific sodium channel blockers.
4

The influence of maternal anxiety, clinical diagnosis, and presentation of medical information on mothers' responses to children's abdominal pain

Williams, Sara Elizabeth, January 2007 (has links)
Thesis (Ph. D. in Psychology)--Vanderbilt University, Dec. 2007. / Title from title screen. Includes bibliographical references.
5

Audio-analgesia for post-operative respiratory exercises a research report submitted in partial fulfillment ... /

Coindreau, Phyllis M. Rogers, Mary L. January 1970 (has links)
Thesis (M.S.)--University of Michigan, 1970.
6

Audio-analgesia for post-operative respiratory exercises a research report submitted in partial fulfillment ... /

Coindreau, Phyllis M. Rogers, Mary L. January 1970 (has links)
Thesis (M.S.)--University of Michigan, 1970.
7

Mechanisms of abdominal pain in paediatric inflammatory bowel disease

Tranter, Michael MacGruber January 2018 (has links)
Introduction. Inflammatory bowel disease (IBD) is a condition affecting more than 3 million people in Europe and the USA combined. Patients report pain as one of the most severe and debilitating symptoms leading to a lower quality of life. Current analgesics lack efficacy for the treatment of visceral pain or produce unacceptable side effect profiles. New targets are needed. Aims and methods. The aim of this thesis was to examine the activation of primary visceral afferents in C57BL/6 mice in response to biopsy supernatants from paediatric patients with IBD (Crohn's disease and ulcerative colitis) and functional abdominal pain syndrome (FAPS). By comparing the expression of pro-inflammatory and pro-nociceptive mediators in these biopsy samples with patient pain scores and afferent nerve recording activation, we identified putative mediators likely to be responsible for causing pain. The ability of inflammatory mediators to drive visceral nociception was then examined by their exogenous application in recordings of mouse and human visceral nociceptor activity. Results. Nerve activation increased significantly in response to biopsy supernatants from FAPS, CD, and UC patients, when compared to controls. Supernatant IL-8, TNFα, IL-6 and IL-1β, levels were increased in IBD samples compared with control patients. Analysis of mRNA expression also showed high levels of pro-inflammatory cytokines and raised MMP-1, MMP-3, MMP-9, MMP-12, and MMP-19 in IBD samples. The expression of MMP-12 in biopsy samples from Crohn's patients significantly correlated with afferent firing suggesting a causative role. This was confirmed by exogenously application of MMP-12 stimulated afferent firing and sensitised responses to mechanical stimulation and inflammatory mediators. UC samples showed TIMP-1 as an effective inhibitor of afferent firing. Conclusion. Data from this study demonstrates that the bowel of patients with IBD and FAP releases pro-nociceptive mediators which stimulate visceral afferents. MMP's play an important role in the afferent activation mediated by IBD samples suggesting that exploiting the endogenous inhibitor TIMP-1 could be a key target for future therapeutic strategies.
8

Ambulanssjuksköterskans omhändertagande av kvinnor och män med buksmärta i prehospital sjukvård med fokus på smärtlindring : En journalgranskningsstudie

Sundset, Ulrika January 2011 (has links)
SAMMANFATTNING Buksmärtor är en av de vanligaste orsakerna till att människor söker sjukvård. Historiskt sett har smärtlindring till patienter med buksmärta varit restriktiv. Otillräcklig smärtlindring kan bero på rädsla för att smärtlindrande läkemedel ska dölja viktiga kliniska tecken som kan leda till diagnostiska svårigheter. Syfte: Att undersöka i vilken omfattning ambulanssjuksköterskan smärtlindrar patienter med buksmärta, i vilken utsträckning patienter smärtskattas samt om det föreligger någon skillnad mellan män och kvinnor när det gäller administrering av smärtlindrande läkemedel och omfattning av smärtskattning prehospitalt. Metod: En retrospektiv jämförande deskriptiv journalgranskning med kvantitativ ansats. Ett konsekutivt urval gjordes och sammanlagt granskades 200 journaler, varav 100 omfattade kvinnor och 100 omfattade män. Resultat: 21 % (n=42) av patienterna smärtlindrades. Det fanns ingen statistisk signifikans som visade att kvinnor och män smärtlindrades i olika omfattning. Det var 34,5 % (n=69) av patienterna som smärtskattades, och ingen skillnad mellan könen påvisades. Denna studie är av betydelse för specialistsjuksköterskor och andra personalkategorier som omhändertar patienter med buksmärta. Studien bidrar med kunskap som kan leda till att det prehospitala omhändertagandet av patienter med buksmärta utvecklas och förbättras. / ABSTRACT Abdominal pain is one of the most common reasons for seeking medical care. Historically, pain relief in patients with abdominal pain has been restrictive. Causes of inadequate pain relief could be fear that analgesics will mask important clinical signs that can lead to diagnostic difficulties. Aim: To investigate to what extent patients with abdominal pain receive analgesics, the extent to which patients’ pain is rated and if there is any difference between men and women in the administration of analgesics and the extent of prehospital pain measurement. Method: A retrospective comparative descriptive medical record review with quantitative data. A consecutive selection was made and a total of 200 medical records were reviewed, 100 involved women and 100 involved men. Result: 21 % (n=42) of the patients were given analgesics. Men and women were treated equally in terms of pain relief. There were 34,5 % (n=69) of the patients who were asked to estimate their pain, and no difference between sexes was detected. This study is relevant to healthcare professionals who treat patients with abdominal pain. The result of this study can be used in the development and the improvement of the prehospital care of patients with abdominal pain.
9

Recurrent pain and health related quality of life in young schoolchildren /

Petersen, Solveig, January 2008 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2008. / Härtill 4 uppsatser.
10

Prospective validation of the Pediatric Appendicitis Score in a Canadian pediatric emergency department

Bhatt, Maala. January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Epidemiology, Biostatistics and Occupational Health. Title from title page of PDF (viewed 2008/12/04). Includes bibliographical references.

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