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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.043 seconds)Spelling suggestions: "subject:"adaptor protein 2"" "subject:"adaptorn protein 2""
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The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosisWall, M.J., Corrêa, Sonia A.L. 07 September 2017 (has links)
Yes / The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target. / The work in S.A.L.C. laboratory is supported by the BBSRC (BB/H018344/1 and BB/J02127X/1) and Wellcome Trust 200646/Z/16/Z. The work in M.J.W. Laboratory is supported by ERUK.
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| 2 |
PC7 : une protéase sécrétoire énigmatique ayant une fonction de sheddase et un ciblage cellulaire uniqueDurand, Loreleï 04 1900 (has links)
No description available.
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