Thesis (Ph. D.)--University of Texas at Austin, 2005. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xi, 123 p. Includes bibliographical references (p. 51-58). Available online via OhioLINK's ETD Center

Thesis (M.S. in Psychology)--Vanderbilt University, May 2006. / Title from title screen. Includes bibliographical references.

This thesis examined differences in reasoning concerning hypothetical versus real-life moral situations in order to better understand the moral development of delinquents in general, and psychopaths in particular. Participants ranged in age from 15 to 18 years and were divided into three subgroups: 14 psychopaths, 15 delinquents, and 15 normal youths (total N = 44). All subjects were individually interviewed and assessed on (a) Hare's (1985) psychopathy checklist, (b) two of Kohlberg's hypothetical moral dilemmas, and (c) a subject-generated real-life moral dilemma. Reasoning regarding these dilemmas was scored for both moral stage and moral orientation. It was found that the normal youths attained a higher level of moral reasoning than both the delinquents and psychopaths. Secondly, it was found that all groups scored lower on the real-life than the hypothetical dilemmas, indicating that hypothetical dilemmas may elicit a person's best level of reasoning, whereas real-life dilemmas may entail factors which lower the level of moral reasoning used in an actual situation of moral conflict. Third, non-incarcerated subjects were found to use more of the perfectionism and fairness orientations (Subtype B) than did the incarcerated. It was also found that psychopaths used more of the egoistic utilitarianism orientation than did non-psychopaths when discussing real-life dilemmas. That is, they focused more on issues related to themselves than did either the delinquents or the normals. Thus, this study reveals a pattern of deficiencies in the moral reasoning development of psychopaths and delinquents when compared to their normal counterparts. As well, hypothetical and real-life dilemmas were found to differ in the level of moral reasoning that they elicited. / Arts, Faculty of / Psychology, Department of / Graduate

Cognitive impairments are a hallmark of many, if not all, psychiatric disorders. They include deficits in working memory, attention, and cognitive flexibility. The prefrontal cortex (PFC) is essential for these cognitive functions and has been implicated in psychiatric disorders, including schizophrenia. The PFC receives reciprocal inputs from the thalamus, and this thalamo-PFC circuitry supports cognition. In patients with schizophrenia, who have impaired cognitive functioning, thalamo-PFC connectivity is disrupted. This finding is also seen in adolescents at high risk for the disorder, even before diagnosis.While impaired cortical maturation has been postulated as a mechanism in the etiology of schizophrenia, the postnatal development of thalamo-PFC circuitry is still poorly understood. In sensory cortex, activity relayed by the thalamus during a postnatal sensitive period is essential for proper cortical maturation. However, whether thalamic activity also shapes maturation of the PFC is unknown. Here, I will present evidence to support the hypothesis that adolescence represents a sensitive period, during which the PFC is susceptible to transient perturbations in thalamic input activity, resulting in persistent changes in circuitry. In Chapter 1, I present the existing literature on schizophrenia and our current understanding of its etiology. I then review the structure and connectivity of the PFC and its inputs, including the thalamus, in the context of schizophrenia and cognition. Next, I discuss the role of adolescence in the development of these structures and circuits. Finally, I introduce the concept of sensitive periods and outline the hypothesis that a similar process may occur in the context of the adolescent development of thalamo-PFC circuitry. To assess cognitive functioning in mouse models, I developed an operant-based working memory task. In Chapter 2, I describe this newly developed task and demonstrate that behavioral performance in the task is susceptible to PFC lesions. Thus, the task offers a new approach to studying PFC cognitive function. In Chapter 3, I discuss work done to address the hypothesis of adolescence as a sensitive period in the development of thalamo-PFC circuitry. I established an approach whereby I can transiently reduce activity in the thalamus during specific time windows. In this way, I compared the persistent effects of transient thalamic inhibition during adolescence and adulthood. I found that adolescent thalamic inhibition causes long-lasting deficits in cognitive behavioral performance, including the operant-based working memory task described in Chapter 2 and a cognitive flexibility task, decreased PFC cellular excitability, and reduced thalamo-PFC projection density. Meanwhile, adult thalamic inhibition has no persistent consequences on behavior or PFC excitability. Adolescent thalamic inhibition also results in disrupted PFC cellular cross-correlations and task outcome encoding during the cognitive flexibility task. Strikingly, exciting the thalamus in adulthood during the behavioral task rescues PFC cross-correlations, task outcome encoding, and the cognitive deficit. These data support the hypothesis that adolescence is a sensitive period in thalamo-PFC circuit maturation as adolescent thalamic inhibition has long-lasting consequences on PFC circuitry, while adult thalamic inhibition has no persistent effects. Moreover, these results highlight the role of the thalamus as a non-specific facilitator of PFC activity, expanding our understanding of this thalamic function to additional cognitive contexts. By supporting PFC network activity, boosting thalamic activity provides a potential therapeutic strategy for rescuing cognitive deficits in neurodevelopmental disorders. Finally, in Chapter 4, I conclude with a general discussion. I highlight major take-aways from this work as well as next steps in our exploration of these crucial neural circuits. Together, the findings outlined here offer new promise for early diagnosis and treatment options for patients with cognitive impairments and psychiatric disorders.

Family-based treatments for adolescent substance abuse demonstrate efficacy and are becoming a treatment of choice. Family risk factors for substance abuse may present barriers to or suggest targets for modification during treatment. The sample included 149 adolescents presenting for substance abuse treatment and their parents. Structural equation modeling tested the hypothesis that parent psychological problems, parent substance use, and parenting behaviors influence adolescent psychological problems and substance use. This study is among the first to examine the unique impact of maternal and paternal variables on adolescent problems within one analytical model. Results indicated that parental psychological problems were directly associated with adolescent psychological problems after controlling for parent substance use and parenting behaviors. Paternal positive involvement and poor monitoring were also independently associated with adolescent substance use. Results suggest that both mothers' and fathers' symptoms of psychopathology play an important role in the symptoms of adolescents in treatment for substance abuse. Findings highlight the need for family-based assessment in adolescent treatment populations to address important clinical and research questions.

No description available.

Objectives: To describe the co-occurrence of substance use and sexual activity behaviors among Afro-Caribbean adolescents living in South Florida, with attention to legal status, socio-demographic factors and risk-taking attitudes and behaviors. Methods: Convenience sampling was used to select 106 Afro-Caribbean adolescents from community centers in South Florida. A descriptive exploratory study was conducted. Data was analyzed using an independent t test, frequencies and crosstabs. Results: The study consists of 106 adolescents, 75% (n = 79) documented and 25% (n = 27) undocumented. Forty-one documented and 10 undocumented adolescents were sexually active. Of those, 14.6% of the documented and 40% of the undocumented adolescents had been drinking alcohol while engaging in sexual activity; 7.3% of documented and 30% of undocumented adolescents used drugs while engaging in sexual activity. Undocumented adolescents had less adult presence before and after school; Creole was spoken at home more than English, and none of the parents had gone to or graduated from college. There was no significant difference in risk-taking and social adaptation scores as measured by the Adolescent Risk-Taking Instrument (ARTI) for the documented and undocumented Afro-Caribbean adolescents. The ARTI had acceptable internal consistency reliability for the risk-taking (.87) and social adaption (.82) scale in this population. The mean score of risk behavior was 2.04 (SD = .44) for documented Afro-Caribbean adolescents and 1.89 (SD = .47) for undocumented adolescents. For social adaptation, mean scores were 3.23 (SD = .45) for documented and 3.20 (SD = .35) for undocumented adolescents. The co-occurrence of substance use and sexual activity is nearly triple for alcohol use and more than triple for drug use when comparing undocumented to documented adolescents. / However, scores on the ARTI did not differ.Socio-demographic factors related to risky behaviors suggest that the undocumented adolescents were more at risk. Health risk of undocumented adolescents demands more research attention if nurses wish to address the unique needs of this population. / by Kim Jolly. / Thesis (Ph.D.)--Florida Atlantic University, 2009. / Includes bibliography. / Electronic reproduction. Boca Raton, Fla., 2009. Mode of access: World Wide Web.

The construct of psychopathy holds promise as a discriminating variable in the classification and explanation of childhood antisocial behavior. The new generation of psychopathy measures, designed to measure this construct in adolescent populations, must meet acceptable standards of reliability and validity prior to the clinical application of the construct with adolescent offenders. The purpose of this study is to examine the construct and predictive validity of adolescent psychopathy as measured by the PCL:YV, PSD, SALE, and SRP-II. Data from two samples of detained adolescent offenders (short-term and long-term detention) are utilized to investigate construct validity via MTMM. In addition, external validity indices including institutional violations (fighting, seclusions, and treatment refusals) and community supervision (probation contacts, drug testing, and re-arrests) are operationalized and measured in order to examine the predictive validity of adolescent psychopathy. Results of construct validity offer modest support for the two-factor model of psychopathy. For external validity, Factor 2 accounted for greater variance in the prediction of institutional infractions and subsequent placements in a secure facility; however, its overall predictive validity was low. The results suggest that the current measures assess psychopathic traits and behaviors which may be stable in adults but are likely to be normative and transient in many adolescents.

Individuals presenting with high levels of psychopathy demonstrate chronic and severe antisocial behavior and poor treatment outcomes in response to generalized rehabilitative programs. Recent research has examined the relationship between delinquency in child/adolescent populations and subsequent psychopathy. Focusing on community based/referred population of at-risk youth, this study developed and examined the effectiveness of an 18-session, psychopathy-focused, group CBT treatment program. The study incorporated treatment (n = 34) and usual-care comparison (n = 30) groups and a brief follow up period. Treatment outcomes examined measures of psychopathy, anger, impulsivity, motivation for treatment, self-reported problems, and indices of behavior. The treatment program demonstrated reductions in psychopathy on the Interpersonal (d = .55) and Affective facets (d = .24) of the PCL:YV. It also reduced overall impulsivity and improved anger suppression and treatment motivation, particularly among youth presenting with higher levels (relative to this study) of psychopathy. As a result of treatment, decreased incidents with the juvenile justice system were also observed, both during the treatment period and at six weeks follow-up. This study provides an initial empirical foundation for the ongoing development of targeted interventions for youth demonstrating psychopathic traits.