by Lo Ping Fai. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1987. / Includes bibliographical references.

by Josephine Wing Sze Lau. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 84-112). / Abstracts in English and Chinese. / Acknowledgment --- p.iii / Abstract --- p.iv / List of Abbreviations --- p.viii / Chapter CHAPTER ONE: --- INTRODUCTION / Chapter 1.1 --- Methamphetamine (METH) --- p.1 / Chapter 1.1.1 --- Historical Background and Epidemiology --- p.1 / Chapter 1.1.2 --- Physical Effects of METH --- p.4 / Chapter 1.1.3 --- Neurochemical Alternation of METH --- p.6 / Chapter 1.2 --- Mechanisms of METH Toxicity / Chapter 1.2.1 --- Oxidative Stress --- p.8 / Chapter 1.2.1.1 --- Superoxide (O2-) and Superoxide Dismutase (SOD) --- p.10 / Chapter 1.2.1.2 --- "Hydrogen Peroxide (H202), Catalase and Glutathione (GSH)" --- p.11 / Chapter 1.2.1.3 --- Hydroxyl Radical (OH.) --- p.12 / Chapter 1.2.1.4 --- Nitric Oxide (NO) --- p.13 / Chapter 1.2.2 --- Apoptosis --- p.16 / Chapter 1.2.3 --- Excitotoxicity --- p.17 / Chapter 1.2.4 --- Mitochondrial Dysfunction --- p.18 / Chapter 1.2.5 --- Hyperthermia --- p.21 / Chapter 1.2.5.1 --- Cyclooxygenase-2 (COX-2) --- p.23 / Chapter 1.2.5.2 --- Heme-oxygenase-1 (HO-1) --- p.25 / Chapter 1.2.5.3 --- The Effects of Nitric Oxide (NO) on COX-2 and HO-1 Expressions --- p.27 / Chapter 1.3 --- Astrocytes / Chapter 1.3.1 --- Characteristics of Astrocytes --- p.29 / Chapter 1.3.2 --- Astrocyte Functions --- p.30 / Chapter 1.3.3 --- The Role of Astrocytes in METH-induced Neurotoxicity --- p.34 / Chapter 1.4 --- Aim of Project --- p.37 / Chapter CHAPTER TWO: --- MATERIALS AND METHODS / Chapter 2.1 --- Cell Cultures / Chapter 2.1.1 --- Astrocyte Cultures --- p.42 / Chapter 2.1.2 --- CATH.a Cell line and Astrocytes Co-cultures --- p.43 / Chapter 2.2 --- Treatment / Chapter 2.2.1 --- METH Treatment --- p.44 / Chapter 2.2.2 --- Inhibition of Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (iNOS) --- p.44 / Chapter 2.3 --- Lactate Dehydrogenase (LDH) Assay --- p.45 / Chapter 2.4 --- Assay for Reactive Oxygen Species (ROS) Formation --- p.47 / Chapter 2.5 --- Assay for Adenosine Triphosphate (ATP) Content --- p.48 / Chapter 2.6 --- Determination of Mitochondrial Membrane Potential (Δ Ψm) --- p.50 / Chapter 2.7 --- Determination of Nitrite Levels in Cultured Astrocytes --- p.51 / Chapter 2.8 --- Western Blot Analysis --- p.52 / Chapter 2.8.1 --- COX-2 --- p.53 / Chapter 2.8.2 --- HO-1 --- p.53 / Chapter 2.9 --- Viability Assay of CATH.a-Astrocyte Cocultures --- p.54 / Chapter 2.10 --- Statistics --- p.55 / Chapter CHAPTER THREE: --- RESULTS / Chapter 3.1 --- The Effects of METH Treatment on Cultured Astrocytes / Chapter 3.1.1 --- Lactate Dehydrogenase (LDH) Activities --- p.56 / Chapter 3.1.2 --- Morphological Changes --- p.56 / Chapter 3.1.3 --- The Production of Reactive Oxygen Species / Chapter 3.1.3.1 --- Rate of change (0-120 min) --- p.57 / Chapter 3.1.3.2 --- Time course (0 - 48 h) --- p.57 / Chapter 3.1.4 --- Change in ATP Content --- p.58 / Chapter 3.1.5 --- Change in Mitochondrial Membrane Potential (Δ Ψm) --- p.59 / Chapter 3.1.6 --- Nitrite levels after METH treatment / Chapter a) --- Striatal astrocytes --- p.59 / Chapter b) --- Mesencephalic astrocytes --- p.60 / Chapter c) --- Cortical astrocytes --- p.60 / Chapter 3.1.7 --- The Effects of Aminoguanidine (AG) on Nitrite Levels / Chapter a) --- Striatal astrocytes --- p.61 / Chapter b) --- Mesencephalic astrocytes --- p.62 / Chapter c) --- Cortical astrocytes --- p.62 / Chapter 3.1.8 --- The Effects of Indomethacin (INDO) on Nitrite Levels / Chapter a) --- Striatal astrocytes --- p.63 / Chapter b) --- Mesencephalic astrocytes --- p.64 / Chapter c) --- Cortical astrocytes --- p.64 / Chapter 3.1.9 --- Change in Cyclooxygenase-2 (COX-2) Protein Levels / Chapter a) --- Striatal astrocytes --- p.65 / Chapter b) --- Mesencephalic astrocytes --- p.65 / Chapter c) --- Cortical astrocytes --- p.66 / Chapter 3.1.10 --- Change in Heme-oxygenase-1 (HO-1) Protein Levels / Chapter a) --- Striatal astrocytes --- p.66 / Chapter b) --- Mesencephalic astrocytes --- p.66 / Chapter c) --- Cortical astrocytes --- p.67 / Chapter 3.2 --- Cell Viability on CATH.a-Astrocyte Cocultures After METH Treatment --- p.67 / Chapter CHAPTER FOUR: --- DISCUSSION AND CONCLUSION --- p.69 / REFERENCES --- p.84

by Chan Tung. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references (leaves 85-102). / Abstract and questionnaire also in Chinese. / Abstract --- p.i / Chinese abstract --- p.ii / Table of contents --- p.iii / Acknowledgment --- p.v / List of tables --- p.vi / List of figures --- p.vii / Glossary of terms and abbreviations --- p.viii / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Asthma epidemiology --- p.1 / Chapter 1.2 --- Aim of study --- p.3 / Chapter Chapter 2 --- Literature review --- p.4 / Chapter 2.1 --- Definitions of asthma --- p.4 / Chapter 2.2 --- Questionnaire in asthma epidemiological surveys --- p.7 / Chapter 2.3 --- Asthma prevalence studies in Western populations --- p.9 / Chapter 2.4 --- Asthma prevalence studies in Hong Kong --- p.13 / Chapter 2.4.1 --- Adult asthma --- p.14 / Chapter 2.4.2 --- Childhood asthma --- p.15 / Chapter 2.4.3 --- Asthma mortality --- p.17 / Chapter 2.5 --- Environmental risk factors of asthma --- p.17 / Chapter 2.5.1 --- Allergens --- p.19 / Chapter 2.5.2 --- Air pollution --- p.23 / Chapter 2.5.3 --- Environmental tobacco smoke --- p.27 / Chapter 2.5.4 --- Viral infections --- p.29 / Chapter 2.5.5 --- Dietary factors --- p.30 / Chapter 2.5.6 --- Allergen avoidance --- p.32 / Chapter Chapter 3 --- Epidemiological survey --- p.34 / Chapter 3.1 --- Subjects and methods --- p.34 / Chapter 3.1.1 --- Subjects --- p.34 / Chapter 3.1.2 --- Written questionnaire --- p.35 / Chapter 3.1.3 --- Video questionnaire --- p.36 / Chapter 3.1.4 --- Bronchial hyperresponsiveness testing --- p.38 / Chapter 3.2 --- Results --- p.42 / Chapter 3.3 --- Discussion --- p.55 / Chapter Chapter 4 --- Environmental survey --- p.63 / Chapter 4.1 --- Subjects and methods --- p.63 / Chapter 4.1.1 --- Subjects --- p.63 / Chapter 4.1.2 --- Questionnaire survey --- p.63 / Chapter 4.1.3 --- Allergen sampling --- p.64 / Chapter 4.2 --- Results --- p.68 / Chapter 4.3 --- Discussion --- p.73 / Chapter Chapter 5 --- Overall discussion and conclusions --- p.81 / References --- p.85 / Appendix

by Lee Suk Fan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 140-157). / Abstracts in English and Chinese. / Acknowledgements --- p.ii / Abstract --- p.iii / 槪論 --- p.v / List of Abbreviations --- p.vii / Chapter Chapter 1 --- Introduction --- p.1 / Chapter Chapter 2 --- Sex Difference in Alcohol Consumption on Hamster --- p.31 / Chapter Chapter 3 --- Effect of Chronic Alcohol Consumption --- p.65 / Chapter Chapter 4 --- Effect of Green Tea Polyphenols on Alcohol Metabolizing Enzymes in Hamster --- p.108 / Chapter Chapter 5 --- Conclusion --- p.135 / References --- p.140

Chu Ching Yan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (leaves 170-189). / Abstracts in English and Chinese. / Chapter 1 --- General Introduction --- p.1 / Chapter 1.1 --- Classes of Fatty Acids --- p.3 / Chapter 1.2 --- Polyunsaturated Fatty Acids (n-6 & n-3) --- p.4 / Chapter 1.2.1 --- "High Fish Oil Content in Diet, High n-3 PUFAs Intake, Fight against Cardiovascular Risk" --- p.4 / Chapter 1.2.2 --- n-3 Fatty Acids Improve Hypertension --- p.7 / Chapter 1.2.3 --- n-3 Fatty Acids Protect from Atherosclerosis --- p.8 / Chapter 1.2.4 --- PUFAs are Beneficial in Inflammation --- p.11 / Chapter 1.2.5 --- n-3 PUFAs Help to Control Tumour Growth --- p.13 / Chapter 1.3 --- Obesity and Eating Disorder --- p.14 / Chapter 1.3.1 --- "Obesity, a Companion of the Modern World" --- p.14 / Chapter 1.3.2 --- Health Risks Related to Obesity --- p.16 / Chapter 1.3.3 --- Management of Obesity --- p.19 / Chapter 1.3.4 --- Care Must be Taken to Prevent the Development of Eating Disorder or Other Psychological Disturbances during Weight Loss Programme --- p.21 / Chapter 2 --- Weight Cycling with ChowDiet --- p.24 / Chapter 2.1 --- Introduction --- p.24 / Chapter 2.1.1 --- Definition of Weight Cycling --- p.25 / Chapter 2.1.2 --- Incentives Leading to Weight Cycling --- p.26 / Chapter 2.1.3 --- Problems Aroused by Weight Cycling --- p.26 / Chapter 2.1.3.1 --- "Food Preference, Efficiency and Expenditure" --- p.27 / Chapter 2.1.3.2 --- Increased Overall and Central Adiposity --- p.28 / Chapter 2.1.3.3 --- Increased Morbidity and Mortality of Cardiovascular Disease --- p.29 / Chapter 2.1.3.4 --- Psychological Impact and Social Consequences --- p.30 / Chapter 2.2 --- Objective --- p.30 / Chapter 2.3 --- Materials and Methods --- p.31 / Chapter 2.3.1 --- Animal Handling --- p.31 / Chapter 2.3.2 --- Lipid Analysis --- p.35 / Chapter 2.3.2.1 --- Adipose Tissues --- p.35 / Chapter 2.3.2.2 --- Carcass --- p.36 / Chapter 2.3.3 --- Proximate Analysis --- p.37 / Chapter 2.3.3.1 --- Crude Fat --- p.37 / Chapter 2.3.3.2 --- Crude Protein --- p.38 / Chapter 2.3.3.3 --- Moisture --- p.40 / Chapter 2.3.3.4 --- Ash --- p.40 / Chapter 2.3.4 --- Serum Analysis --- p.41 / Chapter 2.3.4.1 --- Serum Triglycerides --- p.41 / Chapter 2.3.4.2 --- Serum Cholesterol --- p.42 / Chapter 2.4 --- Results --- p.44 / Chapter 2.4.1 --- Body Weight --- p.44 / Chapter 2.4.2 --- Food Intake --- p.44 / Chapter 2.4.3 --- Organ Weight --- p.47 / Chapter 2.4.3.1 --- Liver --- p.47 / Chapter 2.4.3.2 --- Adipose Tissues --- p.47 / Chapter 2.4.4 --- Lipid Analysis --- p.52 / Chapter 2.4.4.1 --- Adipose Tissues --- p.52 / Chapter 2.4.4.2 --- Carcass --- p.52 / Chapter 2.4.5 --- Proximate Analysis --- p.60 / Chapter 2.4.5.1 --- Crude Fat --- p.60 / Chapter 2.4.5.2 --- Moisture --- p.60 / Chapter 2.4.5.3 --- Crude Protein and Ash --- p.62 / Chapter 2.4.6 --- Serum Analysis --- p.64 / Chapter 2.4.6.1 --- Serum Triglycerides --- p.64 / Chapter 2.4.6.2 --- Serum Cholesterol --- p.64 / Chapter 2.5 --- Discussion --- p.66 / Chapter 3 --- Degrees of Food Restriction on Bod y Fa tty Acid Composition --- p.71 / Chapter 3.1 --- Introduction --- p.71 / Chapter 3.1.1 --- Skipping Breakfast --- p.71 / Chapter 3.1.2 --- "Nibbling, Grazing vs Gorging" --- p.72 / Chapter 3.1.3 --- Reducing Food Intake in Meals --- p.74 / Chapter 3.1.3.1 --- Anti-Aging Action --- p.74 / Chapter 3.1.3.2 --- Effects on Other Health Issues --- p.75 / Chapter 3.1.3.3 --- Energy Expenditure --- p.77 / Chapter 3.2 --- Objective --- p.78 / Chapter 3.3 --- Materials and Methods --- p.79 / Chapter 3.3.1 --- Animal Handling --- p.79 / Chapter 3.4 --- Results --- p.81 / Chapter 3.4.1 --- Body Weight --- p.81 / Chapter 3.4.2 --- Food Intake --- p.81 / Chapter 3.4.3 --- Organ Weight --- p.83 / Chapter 3.4.3.1 --- Liver --- p.83 / Chapter 3.4.3.2 --- Adipose Tissues --- p.83 / Chapter 3.4.4 --- Lipid Analysis --- p.88 / Chapter 3.4.4.1 --- Adipose Tissues --- p.88 / Chapter 3.4.4.2 --- Carcass --- p.88 / Chapter 3.4.5 --- Proximate Analysis --- p.102 / Chapter 3.4.5.1 --- Crude Fat --- p.102 / Chapter 3.4.5.2 --- Moisture --- p.102 / Chapter 3.4.5.3 --- Crude Protein and Ash --- p.103 / Chapter 3.4.6 --- Serum Analysis --- p.106 / Chapter 3.4.6.1 --- Serum Triglycerides --- p.106 / Chapter 3.4.6.2 --- Serum Cholesterol --- p.106 / Chapter 3.5 --- Discussion --- p.108 / Chapter 4 --- Food Restriction with Diets Containing Various Amount of FAT --- p.112 / Chapter 4.1 --- Introduction --- p.112 / Chapter 4.1.1 --- Adverse Effects of High-Fat Diets --- p.113 / Chapter 4.1.2 --- Adverse Effects of Low-Fat Diets --- p.114 / Chapter 4.2 --- Objective --- p.116 / Chapter 4.3 --- Materials and Methods --- p.117 / Chapter 4.3.1 --- Animal Handling --- p.117 / Chapter 4.4 --- Results --- p.120 / Chapter 4.4.1 --- Body Weight --- p.120 / Chapter 4.4.2 --- Food Intake --- p.120 / Chapter 4.4.3 --- Organ Weight --- p.122 / Chapter 4.4.3.1 --- Liver --- p.122 / Chapter 4.4.3.2 --- Adipose Tissues --- p.122 / Chapter 4.4.4 --- Lipid Analysis --- p.127 / Chapter 4.4.4.1 --- Adipose Tissues --- p.127 / Chapter 4.4.4.2 --- Carcass --- p.127 / Chapter 4.4.5 --- Proximate Analysis --- p.147 / Chapter 4.4.5.1 --- Crude Fat --- p.147 / Chapter 4.4.5.2 --- Moisture --- p.147 / Chapter 4.4.5.3 --- Crude Protein and Ash --- p.148 / Chapter 4.4.6 --- Serum Analysis --- p.151 / Chapter 4.4.6.1 --- Serum Triglycerides --- p.151 / Chapter 4.4.6.2 --- Serum Cholesterol --- p.151 / Chapter 4.5 --- Discussion --- p.153 / Chapter 5 --- Future Prospects --- p.159 / Chapter 5.1 --- Leptin --- p.159 / Chapter 5.2 --- Enzymes --- p.162 / Chapter 6 --- Conclusion --- p.166 / Chapter 7 --- References --- p.170

Orientador: Silvana Andrea Molina Lima / Resumo: A cultura de segurança pode ser definida como padrões de comportamento de indivíduos e/ou grupos, baseando-se em valores e atitudes, e que podem determinar a maneira como exercerão seu trabalho. Uma cultura de segurança positiva estabelece uma boa comunicação institucional e um compartilhamento eficaz da percepção sobre a importância da segurança e da confiança nas medidas preventivas adotadas. O presente trabalho teve como objetivo analisar a cultura de segurança do paciente sob a perspectiva dos enfermeiros de um hospital terciário do interior do estado de São Paulo. Trata-se de estudo quantitativo, transversal e descritivo. Foi aplicado o instrumento Hospital Survey on Patient Safety Culture (HSOPSC), validado e traduzido para o português pela ENSP – Fiocruz. A coleta dos dados foi realizada no período de agosto de 2017 a fevereiro de 2018. Após análise dos dados, verificou-se que a população é predominantemente do sexo feminino, e com idade média de 34,19 ± 6.29 anos. A maioria dos enfermeiros tem carga horária de trabalho entre 40 a 59 horas, um tempo de trabalho no hospital e na unidade menor de 5 anos. Em relação as dimensões do questionário sobre a cultura de segurança do paciente, foram avaliadas no geral, de forma positiva. Apenas a dimensão “Quadro de Funcionários” e “Percepção geral de segurança do paciente” foi avaliada de maneira negativa. A instituição possui uma cultura de segurança, uma vez que os profissionais enfermeiros realizam as notificações de ocorrênc... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Safety culture can be defined as a behavioral pattern of individuals and groups, based on their values and attitudes, and that determine the way in which they carry out their work. A safety culture is positive in relation to safety and an effective control of safety in safety and security in the preventive measures adopted. The present study had the objective of analyzing the patient 's culture from the perspective of the nurses of a tertiary hospital in the interior of the state of. This is a quantitative, cross-sectional study. The instrument Hospital Research on Patient Safety Culture, validated and translated into Portuguese by National public health school - Fiocruz, was applied. Data collection was performed from August 2017 to February 2018. After data analysis, the population was predominantly female, with a daily average of 34.19 ± 6.29 years. Most professionals have a working time between 40 and 59 hours. Regarding the dimensions of the filter on the safety culture of the patient, they were evaluated in general, in a positive way. Only one "Employee Scale" and "General Perception of Patient Safety" dimension was evaluated negatively. The institution has a safety culture, since nursing professionals perform events of adverse events such as the existence of an error and the incident without harm. The implementation, evaluation of results, investments in the systematic of errors and professional suitability can strengthen the security in the institution. It is conclude... (Complete abstract click electronic access below) / Mestre

Lam Wai-man Wynnie. / "April 2002." / Thesis (M.D.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (p. 109-134). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web.

Liu Ming Ju. / "June 2003." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2003. / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Kwong Man Kwong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 83-99). / TABLE OF CONTENTS --- p.i / ACKNOWLEDGEMENTS --- p.vi / LIST OF FIGURES --- p.vii / LIST OF ABBREVIATIONS --- p.ix / Chapter I. --- ABSTRACT --- p.1 / Chapter II. --- INTRODUCTION --- p.4 / Chapter III. --- LITERATURE REVIEW --- p.6 / Chapter A. --- EXCITATORY AMINO ACIDS AND EXCITOTOXICITY --- p.6 / Chapter 1. --- GLUTAMATE RECEPTORS --- p.7 / Chapter 2. --- NMDA RECEPTOR --- p.9 / Chapter 3. --- EXCITOTOXICITY --- p.10 / Chapter a. --- ACUTE PHASE --- p.10 / Chapter b. --- DELAYED PHASE --- p.11 / Chapter c. --- MECHANISM --- p.11 / Chapter i) --- Inhibition of Na+，K+-ATPase --- p.12 / Chapter ii) --- Impaired Mitochondrial Calcium Buffering --- p.12 / Chapter iii) --- Perturbation of Cytoskeletal Organisation --- p.13 / Chapter iv) --- Phospholipase Activation --- p.14 / Chapter v) --- Endonuclease Activation --- p.15 / Chapter vi) --- Protein Kinase C Activation --- p.15 / Chapter vii) --- Xanthine Oxidase Activation --- p.16 / Chapter viii) --- Nitric Oxidase Synthase Activation --- p.16 / Chapter B. --- APOPTOSIS --- p.19 / Chapter 1. --- MORPHOLOGICAL CHANGES --- p.19 / Chapter 2. --- BIOCHEMICAL AND MOLECULAR CHANGES --- p.20 / Chapter 3. --- APOPTOTIC MEDIATORS --- p.21 / Chapter a. --- INTERLEUKIN-1β CONVERTING ENZYME (ICE) --- p.21 / Chapter b. --- ENDONUCLEASE --- p.22 / Chapter c. --- NITRIC OXIDE SYNTHASE (NOS) --- p.23 / Chapter d. --- POLY(ADP-RIBOSE) POLYMERASE (PARP) --- p.24 / Chapter e. --- CALPAINS --- p.25 / Chapter IV. --- NMDA INDUCED APOPTOSIS IN RAT RETINA --- p.27 / Chapter A. --- RATIONALE --- p.27 / Chapter B. --- MATERIALS AND METHODS --- p.31 / Chapter 1. --- NMDA INDUCED EXCITOTOXICITY --- p.31 / Chapter a. --- INTRAVITREAL INJECTIONS --- p.31 / Chapter b. --- RETINAL GANGLION CELL COUNTS (RGCC) --- p.32 / Chapter i) --- Flat Preparation of Rat Retina --- p.33 / Chapter ii) --- RGCC --- p.33 / Chapter d. --- INNER RETINAL THICKNESS (IRT) --- p.34 / Chapter i. --- Preparation of Epoxyl Specimens --- p.34 / Chapter ii. --- Measurement of IRT --- p.36 / Chapter 2. --- DOSE RESPONSE STUDY OF NMDA --- p.36 / Chapter 3. --- NMDA INDUCED APOPTOSIS IN RAT RETINA --- p.37 / Chapter a. --- GEL ELECTROPHORESIS OF RETINAL DNA --- p.37 / Chapter b. --- HISTOPATHOLOGICAL STUDIES --- p.39 / Chapter i) --- Light Microscopy --- p.39 / Chapter ii) --- Terminal Deoxynucleotidyl Transferase-mediated dUTP-biotin Nick End Labelling (TUNEL) --- p.40 / Chapter iii) --- Electron Microscopy (EM) --- p.41 / Chapter c. --- MORPHOMETRY --- p.41 / Chapter i) --- TUNEL Positive Nuclei --- p.41 / Chapter ii) --- RGCC and IRT --- p.42 / Chapter 4. --- STUDY OF ENZYME INHIBITORS --- p.42 / Chapter C. --- RESULTS --- p.43 / Chapter 1. --- EXCITOTOXICITY IN RAT RETINA --- p.43 / Chapter a. --- RGCC --- p.43 / Chapter b. --- IRT --- p.44 / Chapter 2. --- DOSE DEPENDENT TISSUE RESPONSES AND REGIONAL RESPONSES --- p.44 / Chapter a. --- RGCC --- p.44 / Chapter b. --- IRT --- p.45 / Chapter 3. --- NMDA INDUCED APOPTOSIS IN RAT RETINA --- p.45 / Chapter a. --- RETINAL DNA GEL ELECTROPHORESIS --- p.46 / Chapter b. --- HISTOPATHOLOGY AND TUNEL --- p.46 / Chapter c. --- MORPHOMETRY OF TUNEL AT THE RGCL AND INL --- p.47 / Chapter d. --- TISSUE RESPONSES AT 7 DAYS AFTER INJECTION --- p.48 / Chapter e. --- EM --- p.48 / Chapter i) --- RGCL --- p.48 / Chapter ii) --- INL --- p.48 / Chapter 4. --- ENZYME INHIBITOR STUDY IN NMDA INDUCED EXCITOTOXICITY --- p.49 / Chapter a. --- EFFECT OF VARIOUS ENZYME INHIBITORS ON RGCC --- p.49 / Chapter b. --- EFFECT OF VARIOUS ENZYME INHIBITORS ON IRT --- p.50 / Chapter D. --- DISCUSSION --- p.51 / Chapter 1. --- NMDA INDUCED EXCITOTOXICITY IN RAT RETINA --- p.51 / Chapter 2. --- DOSE DEPENDENT RESPONSES AND REGIONAL RESPONSES --- p.55 / Chapter 3. --- NMDA INDUCED APOPTOSIS IN RAT RETINA --- p.58 / Chapter 4. --- INHIBITOR STUDY --- p.62 / Chapter a. --- ICE --- p.63 / Chapter b. --- ENDONUCLEASE --- p.65 / Chapter c. --- NOS --- p.67 / Chapter d. --- PARP --- p.69 / Chapter e. --- CALPAIN --- p.70 / Chapter V. --- NMDA INDUCED APOPTOSIS IN RABBIT RETINA --- p.72 / Chapter A. --- RATIONALE --- p.72 / Chapter B. --- MATERIALS AND METHODS --- p.73 / Chapter 1. --- INTRAVITREAL INJECTION OF NMDA --- p.73 / Chapter 2. --- HISTOPATHOLOGY AND TUNEL --- p.74 / Chapter 3. --- MORPHOMETRY OF TUNEL --- p.74 / Chapter 4. --- TISSUE RESPONSES AT 7 DAYS AFTER INJECTION --- p.74 / Chapter a. --- RGCC --- p.74 / Chapter b. --- IRT --- p.74 / Chapter 5. --- EM --- p.75 / Chapter C. --- RESULTS --- p.76 / Chapter 1. --- HISTOPATHOLOGY AND TUNEL --- p.76 / Chapter 2. --- MORPHOMETRY OF TUNEL --- p.77 / Chapter 3. --- TISSUE RESPONSES AT 7 DAYS POST INJECTION --- p.78 / Chapter a. --- RGCC --- p.78 / Chapter b. --- IRT --- p.78 / Chapter 4. --- EM --- p.79 / Chapter a. --- RGCL --- p.79 / Chapter b. --- INL --- p.79 / Chapter B. --- DISCUSSION --- p.80 / Chapter VI. --- CONCLUSION --- p.82 / Chapter VII. --- REFERENCES --- p.83 / Chapter VIII. --- FIGURES --- p.100

Chan Ching-Man Loren. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (leaves 126-144). / Abstracts in English and Chinese. / Acknowledgement --- p.ii / Abstract --- p.iii / Table of Content --- p.vii / List of Figure --- p.ix / List of Abbreviations --- p.xii / Chapter Chapter One --- General Introduction / Chapter 1.1 --- Doxorubicin --- p.1 / Chapter 1.2 --- Antioxidants --- p.11 / Chapter 1.3 --- Flavonoids --- p.17 / Chapter 1.4 --- Protection against doxorubicin-induced cardiotoxicity by antioxidant --- p.25 / Chapter 1.5 --- Aim of research --- p.25 / Chapter Chapter Two --- Study of Cardioprotection Effect of Flavonoids Against Doxorubicin-induced Toxicity in Sprague-Dawley Rats / Chapter 2.1 --- Introduction --- p.27 / Chapter 2.2 --- Materials and Methods --- p.29 / Chapter 2.3 --- Results --- p.37 / Chapter 2.4 --- Discussion --- p.51 / Chapter ChapterThree --- Study of Effect of Flavonoids in Chemotherapy of Doxorubicinin Tumor-bearing Mice / Chapter 3.1 --- Introduction --- p.54 / Chapter 3.2 --- Materials and Methods --- p.56 / Chapter 3.3 --- Results --- p.63 / Chapter 3.4 --- Discussion --- p.80 / Chapter ChapterFour --- Study of the Effect of Flavonoids on Doxorubicin-induced Cytotoxicity on Human Tumor Cell Line and Doxorubicin-resistant Human Tumor Cell Line / Chapter 4.1 --- Introduction --- p.83 / Chapter 4.2 --- Materials and Methods --- p.86 / Chapter 4.3 --- Results --- p.94 / Chapter 4.4 --- Discussion --- p.120 / Chapter Chapter five --- Conclusion --- p.122 / References --- p.126