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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Adverse events in the elderly population of Manitoba treated with antipsychotic pharmacotherapy

Vasilyeva, Irina 21 September 2010 (has links)
The safety of antipsychotic use in elderly persons has recently been questioned. The incidence of adverse events (AEs) (extrapyramidal syndromes (EPS), cerebrovascular and cardiac events, and all-cause mortality) in the elderly users of first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) was compared. Risks of AEs in antipsychotic-exposed persons and non-exposed individuals were also assessed. A population-based retrospective cohort study was conducted in the elderly Manitoba residents who received their first antipsychotic medication between April 1, 2000 and March 31, 2007. Cox proportional hazards models were built to compare risks of AEs in FGA and SGA users, as well as in non-exposed subjects. SGAs were associated with a lower risk of all-cause mortality (adjusted HR 0.683, 95% CI 0.577–0.809) and a higher risk of myocardial infarction (1.614 [1.024–2.543]) compared to FGAs. No significant differences between FGAs and SGAs were found for cerebrovascular events, cardiac arrhythmia and congestive heart failure (CHF) but a higher incidence of EPS was observed for FGAs compared to risperidone. Both FGA and SGA users were at a higher risk of cerebrovascular events (FGAs 1.415 [1.114–1.797]; SGAs 1.611 [1.388–1.869]) and CHF (FGAs 1.228 [0.893–1.689]; SGAs 1.242 [1.003–1.536]) compared to non-exposed subjects. Only FGA-users were at a higher risk of death compared to non-exposed subjects (FGAs 1.387 [1.065–1.805]; SGAs 0.824 [0.708–0.959]). Both FGA and risperidone use were associated with a higher risk of EPS (FGAs 3.503 [2.271–5.403]; risperidone 1.733 [1.214–2.472]). Both classes of antipsychotics might lead to potentially life-threatening AEs. Neither FGAs nor SGAs seem to have a superior overall safety profile. Antipsychotic pharmacotherapy should be prescribed in elderly persons after careful consideration of all risks and benefits.
2

Adverse events in the elderly population of Manitoba treated with antipsychotic pharmacotherapy

Vasilyeva, Irina 21 September 2010 (has links)
The safety of antipsychotic use in elderly persons has recently been questioned. The incidence of adverse events (AEs) (extrapyramidal syndromes (EPS), cerebrovascular and cardiac events, and all-cause mortality) in the elderly users of first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) was compared. Risks of AEs in antipsychotic-exposed persons and non-exposed individuals were also assessed. A population-based retrospective cohort study was conducted in the elderly Manitoba residents who received their first antipsychotic medication between April 1, 2000 and March 31, 2007. Cox proportional hazards models were built to compare risks of AEs in FGA and SGA users, as well as in non-exposed subjects. SGAs were associated with a lower risk of all-cause mortality (adjusted HR 0.683, 95% CI 0.577–0.809) and a higher risk of myocardial infarction (1.614 [1.024–2.543]) compared to FGAs. No significant differences between FGAs and SGAs were found for cerebrovascular events, cardiac arrhythmia and congestive heart failure (CHF) but a higher incidence of EPS was observed for FGAs compared to risperidone. Both FGA and SGA users were at a higher risk of cerebrovascular events (FGAs 1.415 [1.114–1.797]; SGAs 1.611 [1.388–1.869]) and CHF (FGAs 1.228 [0.893–1.689]; SGAs 1.242 [1.003–1.536]) compared to non-exposed subjects. Only FGA-users were at a higher risk of death compared to non-exposed subjects (FGAs 1.387 [1.065–1.805]; SGAs 0.824 [0.708–0.959]). Both FGA and risperidone use were associated with a higher risk of EPS (FGAs 3.503 [2.271–5.403]; risperidone 1.733 [1.214–2.472]). Both classes of antipsychotics might lead to potentially life-threatening AEs. Neither FGAs nor SGAs seem to have a superior overall safety profile. Antipsychotic pharmacotherapy should be prescribed in elderly persons after careful consideration of all risks and benefits.
3

Epidemiology of Patient Safety Events in an Academic Teaching Hospital

Leeder, Ciera January 2016 (has links)
Background: Adverse events are poor health outcomes caused by medical care rather than the underlying disease process. Voluntary reporting is a key component to adverse event reduction; however, incident reporting systems contain many limitations. The Patient Safety Learning System (PSLS) is an electronic incident reporting system with several unique features that were designed to address the weaknesses of previous systems, including a process for physician assessment of reported events to determine their significance. The primary objectives for this study were to determine the positive predictive value of the PSLS for identifying adverse events. Secondary objectives were to identify event, patient, and system-level factors associated with true events, and to assess event rates over time. Methods: I performed a retrospective cohort study using electronic health care data collected data from the Ottawa Hospital, between April 1 2010 and September 30, 2011. We Included all reported patient safety events if they occurred in adults aged 18 and older, admitted to an inpatient ward at the Civic, General, or Heart Institute campus. Events that occurred on Psychiatry, Rehabilitation services, were excluded due to data restrictions. A Clinical Reviewer manually reviewed each event to distinguish true events from non-events. For each hospital program, we used a generalized linear mixed model (GLIMMIX) to predict true events, using the role of the reporter as a random effect. Results: Over the study period, there were 2,569 events reported by hospital staff and physicians. Of these, 660 were rated as adverse events and 1,909 were rated as near misses. This yielded an overall positive predictive value of the PSLS system of 63% (95% CI 62-65%). The variance between reporters was not significant for Critical Care, Heart Institute, Nephrology, Obstetrics and Gynecology, Surgery and Periops, therefore I used a traditional logistic regression model with a common intercept. Number of months the PSLS was available was the only significant covariate found in all programs; the direction of the relationship was the same across all programs, and showed a decrease in true events reported over time. Other common covariates included: time from admission to event, severity of illness, and admission type. All models achieved a good calibration, yet discrimination was poor (c <0.70) in all models except Heart Institute. Discrimination ranged from 65% in Critical Care to 77% in the Heart Institute. Overall, the rate of patient safety events reported for inpatients was 6.39 per 1000 patient days. After an initial learning period, from April 2010-January 2011, in which rates were low, reporting rates increased and stabilized; remaining constant from month to month. The rate of true patient safety event reporting fluctuated greatly from April 2010-January 2011, after which they began to steadily decline. Trends in reporting were similar across hospital campus, reporter, and program. The majority of patient safety events were reported by nurses (44%), and laboratory staff (42%). The remaining 14% of events were reported by the classification ‘Other,’ which included all other hospital staff, such as technicians, physicians, and administrative staff. Only 7 physicians reported events to the PSLS during my study period, therefore, they were categorized under ‘Other’. Conclusions: Despite the many unique advantages of the PSLS, the proportion of true events reported has remained low. The overall utility of statistical models to predict patient safety events is limited. The traditional patient and system-level covariates, which are used to predict risk of adverse outcomes with high accuracy, did not help us discriminate between true patient safety events from non events. It is possible that many different individual and institutional barriers are influencing reporting and perhaps reviewing behavior, which in turn leads to non-clinical variability in what gets reported and classified as a patient safety event.
4

Preventable Deaths at Acute Care Hospitals

Kobewka, Daniel January 2016 (has links)
Background Previous measurements of preventable death in hospital do not account for the uncertainty of preventability ratings. Objective To determine the proportion of deaths in hospital that a have high probability of being prevented with high quality care. Methods We created summaries for every death at a tertiary care hospital over 4-months. Four reviewers assigned preventability ratings to each death and latent class analysis was used to classify deaths into high and low preventability categories. Results There were 480 decedents with mean age of 73.9. Inter-rater reliability was poor with an intra-class correlation of 0.14. The best latent class model found that 6.2% (95% CI 0.00 – 15.2%) of deaths had a 31.0% probability of being rated more likely preventable than not by each reviewer. In contrast, 93.8% (95% CI 84.8 - 100.0%) of deaths had a 0.8% probability of being rated more likely preventable than not by each reviewer. The incidence of truly preventable deaths is less than the 6.2% that are deemed possibly preventable. xi Conclusion Very few deaths in hospital are preventable. The low incidence of preventable deaths and low inter-rater reliability means that peer review methodology is only sensitive to large differences in preventable death rate.
5

Pediatric Obesity and Peri-Operative Adverse Events

Hawley, Torrey 20 September 2012 (has links)
Most surgeries and many medical procedures commonly make use of some form of anesthesia to maximize patient comfort and safety. However, all are associated with risks. Obesity and related health care problems are relatively common in anesthesia and also have a negative effect on morbidity and mortality. Trends in pediatric obesity show increases in both the prevalence and risks for the development of other disease. Using the 1997 through 2009 Kids’ Inpatient Database (KID), this study will assess diagnostic codes to identify complications related to anesthesia in the obese pediatric population. Information gained from this study may serve to advance research and the development of anesthetic techniques to improve both safety and overall health for this population.
6

Avaliação da notificação de eventos adversos em um hospital universitário do interior de Minas Gerais / Evaluation gives notification in evaluation adverse in a hospital university of inside of Minas Gerais

Mattar, Ana Luiza Rilko 20 December 2017 (has links)
O presente estudo tem o objetivo de analisar as notificações dos incidentes relacionados à assistência à saúde em um hospital universitário brasileiro entre os anos de 2015 e 2016.Para tanto, foram coletados dados secundários dos Eventos Adversos (EA) ocorridos no hospital e registrados no sistema VIGIHOSP, e foram descritos eventos de 8 perfis distintos: Procedimentos cirúrgicos, Quedas, Identificação do Paciente, Flebite, Medicamentos utilizados, Perda do Cateter, Lesão na Pele, e Sangue e Hemocomponentes. Os resultados alcançados têm suporte na literatura, tanto em relação à porcentagem de ocorrência de cada notificação, como também no que diz respeito às notificações que se tornam EA. Uma lacuna foi identificada: a literatura científica reforça bastante o problema da subnotificação e as mazelas dela decorrentes; mas, além desse fato, o que este estudo chama atenção é para a efetividade das notificações incompletas. Sugere-se ao hospital pesquisado a promoção das notificações como parte de uma cultura de segurança, buscando mais os resultados do que os culpados. Propõe-se também a utilização dos EA como indicadores de resultado para a gestão hospitalar, atrelados aos objetivos de qualidade e de custo / This study aims to analyze the reports of incidents related to health care in a Brazilian university hospital during the years 2015 and 2016. To do so, secondary data from Adverse Events (AD) occurred at the hospital and were recorded in the VIGIHOSP system, and events of 8 different profiles were described: Surgical Procedures, Falls, Patient Identification, Phlebitis, Medications Used, Catheter Loss, Skin Injury, and Blood and Hemocomponents. The results obtained are supported in the literature, both in relation to the percentage of occurrence of each notification, as well as with regard to notifications that become AD. A gap has been identified: the scientific literature strongly reinforces the problem of underreporting and the ensuing problems; but beyond this fact, what this study calls attention to is the effectiveness of incomplete notifications. For the researched hospital is suggested to promote the notifications as part of a safety culture, seeking more results than the culprits. It is also proposed the use of AD as outcome indicators for the hospital management, linked to quality and cost objectives
7

Cultura de segurança do paciente na perspectiva dos enfermeiros de um hospital terciário do interior do Estado de São Paulo

Alves, Maryelle Aparecida January 2019 (has links)
Orientador: Silvana Andrea Molina Lima / Resumo: A cultura de segurança pode ser definida como padrões de comportamento de indivíduos e/ou grupos, baseando-se em valores e atitudes, e que podem determinar a maneira como exercerão seu trabalho. Uma cultura de segurança positiva estabelece uma boa comunicação institucional e um compartilhamento eficaz da percepção sobre a importância da segurança e da confiança nas medidas preventivas adotadas. O presente trabalho teve como objetivo analisar a cultura de segurança do paciente sob a perspectiva dos enfermeiros de um hospital terciário do interior do estado de São Paulo. Trata-se de estudo quantitativo, transversal e descritivo. Foi aplicado o instrumento Hospital Survey on Patient Safety Culture (HSOPSC), validado e traduzido para o português pela ENSP – Fiocruz. A coleta dos dados foi realizada no período de agosto de 2017 a fevereiro de 2018. Após análise dos dados, verificou-se que a população é predominantemente do sexo feminino, e com idade média de 34,19 ± 6.29 anos. A maioria dos enfermeiros tem carga horária de trabalho entre 40 a 59 horas, um tempo de trabalho no hospital e na unidade menor de 5 anos. Em relação as dimensões do questionário sobre a cultura de segurança do paciente, foram avaliadas no geral, de forma positiva. Apenas a dimensão “Quadro de Funcionários” e “Percepção geral de segurança do paciente” foi avaliada de maneira negativa. A instituição possui uma cultura de segurança, uma vez que os profissionais enfermeiros realizam as notificações de ocorrênc... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Safety culture can be defined as a behavioral pattern of individuals and groups, based on their values and attitudes, and that determine the way in which they carry out their work. A safety culture is positive in relation to safety and an effective control of safety in safety and security in the preventive measures adopted. The present study had the objective of analyzing the patient 's culture from the perspective of the nurses of a tertiary hospital in the interior of the state of. This is a quantitative, cross-sectional study. The instrument Hospital Research on Patient Safety Culture, validated and translated into Portuguese by National public health school - Fiocruz, was applied. Data collection was performed from August 2017 to February 2018. After data analysis, the population was predominantly female, with a daily average of 34.19 ± 6.29 years. Most professionals have a working time between 40 and 59 hours. Regarding the dimensions of the filter on the safety culture of the patient, they were evaluated in general, in a positive way. Only one "Employee Scale" and "General Perception of Patient Safety" dimension was evaluated negatively. The institution has a safety culture, since nursing professionals perform events of adverse events such as the existence of an error and the incident without harm. The implementation, evaluation of results, investments in the systematic of errors and professional suitability can strengthen the security in the institution. It is conclude... (Complete abstract click electronic access below) / Mestre
8

Avaliação da notificação de eventos adversos em um hospital universitário do interior de Minas Gerais / Evaluation gives notification in evaluation adverse in a hospital university of inside of Minas Gerais

Ana Luiza Rilko Mattar 20 December 2017 (has links)
O presente estudo tem o objetivo de analisar as notificações dos incidentes relacionados à assistência à saúde em um hospital universitário brasileiro entre os anos de 2015 e 2016.Para tanto, foram coletados dados secundários dos Eventos Adversos (EA) ocorridos no hospital e registrados no sistema VIGIHOSP, e foram descritos eventos de 8 perfis distintos: Procedimentos cirúrgicos, Quedas, Identificação do Paciente, Flebite, Medicamentos utilizados, Perda do Cateter, Lesão na Pele, e Sangue e Hemocomponentes. Os resultados alcançados têm suporte na literatura, tanto em relação à porcentagem de ocorrência de cada notificação, como também no que diz respeito às notificações que se tornam EA. Uma lacuna foi identificada: a literatura científica reforça bastante o problema da subnotificação e as mazelas dela decorrentes; mas, além desse fato, o que este estudo chama atenção é para a efetividade das notificações incompletas. Sugere-se ao hospital pesquisado a promoção das notificações como parte de uma cultura de segurança, buscando mais os resultados do que os culpados. Propõe-se também a utilização dos EA como indicadores de resultado para a gestão hospitalar, atrelados aos objetivos de qualidade e de custo / This study aims to analyze the reports of incidents related to health care in a Brazilian university hospital during the years 2015 and 2016. To do so, secondary data from Adverse Events (AD) occurred at the hospital and were recorded in the VIGIHOSP system, and events of 8 different profiles were described: Surgical Procedures, Falls, Patient Identification, Phlebitis, Medications Used, Catheter Loss, Skin Injury, and Blood and Hemocomponents. The results obtained are supported in the literature, both in relation to the percentage of occurrence of each notification, as well as with regard to notifications that become AD. A gap has been identified: the scientific literature strongly reinforces the problem of underreporting and the ensuing problems; but beyond this fact, what this study calls attention to is the effectiveness of incomplete notifications. For the researched hospital is suggested to promote the notifications as part of a safety culture, seeking more results than the culprits. It is also proposed the use of AD as outcome indicators for the hospital management, linked to quality and cost objectives
9

Oral Care and the Connection to Adverse Events in Dentistry

Rhoney, Melissa A 01 January 2018 (has links)
As the healthcare industry continues to change, dental providers are concerned about the different types of adverse events that can occur if systemic diseases are not well understood when treating patients. The purpose of this study was to explore the level of understanding among dental care providers of the relationship between oral care and systemic diseases and how these are linked to adverse events. The theoretical foundation that was used for this study was the Swiss cheese model. The research questions were designed to address the level of understanding among dental care providers of the link between oral care and systemic diseases as well as their perceptions of adverse events in dentistry and why they occur. Using a qualitative phenomenological approach, interviews were conducted with 10 dental care providers who practice in the New Jersey area. As I reviewed the field notes and listened to the audio recording, themes were developed to gain a deeper understanding of the research. The research findings revealed that dental providers have moderate knowledge of systemic disease and that some dentists had encountered an adverse event when providing oral care to patients; this experience led participants to look at patients' overall health instead of only oral care. Positive social change could result from improved training and education for dental providers to gain a better understanding of systemic diseases and systems such as the Swiss cheese model for preventing adverse events in patients with systemic diseases. Dental providers should be more involved with community services by providing health fairs to educate the public about why taking care of their oral health is as important as their physical health.
10

Effects of Staffing and Expenditure Variables on After Surgery Patient Safety in Florida Hospitals

Khuspe, Shaila 13 January 2004 (has links)
Objective: To investigate the association between hospital investment in human resources variables and patient safety, specifically after surgery adverse events in Florida hospitals. We performed the analysis to identify the association of after surgery complication rates with full time equivalent employees (FTEs) per admission and per patient day, expenses per admission and per patient day and, the percent of total operating expense accounted for by payroll expenses. Design: A cross sectional analysis using inpatient hospital discharge data and financial data from seventy short-term general hospitals, both for-profit and not-for-profit. Methods: Discharge data from year 2000 was obtained from Agency for Health Care Administration (AHCA). This data was used to calculate Agency for Healthcare Research and Quality (AHRQ) Patient Safety Indicators (PSIs) related to after surgery complications in 840,945 hospital discharge records from 70 short-term general hospitals across the state of Florida. The predictor variables include: payroll expenditures per admission, payroll expenditures per patient day, personnel (FTE) per admission, personnel (FTE) per patient day and payroll expense as a percent of total operating expenses. Main outcome measures: Nine patient safety indicators defined by AHQR and specific to after surgery complications: complications of anesthesia, foreign body left during procedure, postoperative hemorrhage or hematoma, postoperative physiologic and metabolic derangement, postoperative pulmonary embolism or deep vein thrombosis, postoperative respiratory failure, postoperative sepsis, postoperative wound dehiscence. Results: Patient safety indicator rate showed an inverse relationship with the percent of total operating expense represented by payroll, Personnel per patient day and personnel per admission. The patient safety indicators showing significant relationship with hospital human resource characteristics are postoperative hemorrhage or hematoma (p=0.0002), postoperative hip fracture (p<0.0001), and postoperative sepsis (p=0.0371). Conclusion: Human resource investment is positively related to favorable outcomes, although the effect varies across the type of outcomes.

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