Utilizing a mixed methods approach in assessing cities and metropolitan areas with the highest rates of breast cancer disparities in African-American communities, this study presents the Affiliate perspective of the Susan G. Komen non-profit organization in combination with available socioeconomic data and academic literature. Analyzed through an anthropological lens, qualitative and quantitative data illuminate the lived experiences and dynamic circumstances in which breast cancer disparities are disproportionately experienced in 21 of the nation’s populations of African-Americans. Two main recommendations arose from this research: prioritization of granting to activities such as patient navigation, usage of patient narrative messaging, community-based participatory research methods of program development and implementation, mobile mammography delivery, usage of lay health educators, and self-advocacy education to alleviate barriers to healthcare and supplementation of the current educational activities of the Komen Affiliates through program sharing and leverage of current assets with consideration of current Affiliate capacity. These recommendations may help in alleviating breast cancer disparities present in African-American communities with the highest levels of disparities in the nation.