The emergence of cloud computing is influencing how businesses develop, re-engineer, and implement critical software applications. The cloud requires developers to elevate the importance of compliance with security policies, regulations and internal engineering standards in their software development life cycles. Cloud computing and agile development methodologies are new technologies associated with new approaches in the way computing services are provisioned and development of quality software enhanced. However adoption and use of agile and cloud computing by SMMEs in South Africa is seemingly constrained by a number of technical and non-technical challenges. Using Grounded Theory and case study method this study was aimed at exploring the development of a framework for agile methodologies to promote the adoption and use of cloud computing services by SMMEs in South Africa. Data was collected through survey and in-depth interviews. Open, Axial and Selective coding was used to analyse the data. In tandem with its main objective the study, besides exploring the development of the envisaged framework, also generated and made available valuable propositions and knowledge that SMMEs in South Africa using agile development methodologies can use to work better with cloud computing services in the country without compromising on software quality. The findings of this study and the emerging insights around the development of the framework, which in itself also constitutes an important decision making tool for supporting adoption and use of cloud computing services, are a substantial contribution to knowledge and practice in the ICT field of information systems in South Africa / Information Science / D. Phil. (Information Systems)