[Truncated abstract] In the last ten years regulator T (Tr) cells have re-emerged as an integral part of the immune system. Research in this field has rapidly demonstrated the role of these cells in the maintenance of immune homeostasis and their involvement in disease. Tr cells are generated in the thymus as a normal part of the developing immune system. Furthermore, antigen-specific Tr cells are induced in the periphery by a mechanism which is yet to be completely elucidated, but is likely to involve dendritic cells. Tr cells play an important role in autoimmune disease, transplantation tolerance, cancer. Most recently Tr cell involvement has been demonstrated in a growing number of infectious diseases. Tr cell induction was reported in Friend Virus infection at the commencement of this study, and subsequent to publication of our findings have also been identified in FIV and HIV. Murine AIDS (MAIDS) is a fatal chronic retroviral infection induced in susceptible strains of mice by infection with BM5d, a replication defective virus, in a viral mixture which is designated LP-BM5. The manipulation of Tr cells detailed in this thesis and the related publication represent the first reported therapy utilising targeted removal of Tr cells. Chapter 1 summarises the literature relevant to this study up to November 2004. Chapter 2 details the materials and methodologies used in this work. Chapter 3 investigates whether Tr cells are involved in the development of murine AIDS, particularly in the early stages of infection. The data presented in this chapter provides evidence of a population of CD4+ Tr cells which express CD25 on their cell surface and secrete TGF-β, some IL-10 and low levels of IL-4 are induced following infection with LP-BM5. These cells were found to arise by day 12 post infection (pi) by flow cytometry and immunosuppressive cytokine expression was found to peak at day 16 pi indicating a role in the early stages of disease progression. Chapter 4 investigates the effect of therapeutically targeting these induced Tr cells using the antimitotic agent Vinblastine during their induction period. The efficacy of treatment was found to be time dependent and was shown to abrogate disease progression maximally when given at day 14 pi. Treatment with anti-CD4 monoclonal antibody was also found to be efficacious at day 14 pi and confirmed the identity of the Tr cells as being CD4+ T cells. Adoptive transfer studies demonstrated that the return of these cells to a successfully treated host results in renewed MAIDS progression, confirming their role in disease progression

Thesis (doctoral)--Ludwig-Maximilians-Universität, 1996.

Thesis (doctoral)--Ludwig-Maximilians-Universität, 1996.

Assignment (MPhil)--University of Stellenbosch, 2006. / Bibliography. Also available via the Internet.

AIDS is a serious South African health problem, with HIV infection in KwaZulu-Natal being at the local epidemic's forefront. Adolescents in this province are at additional risk because of their lifestyles. Information on existing risky behaviour and its psychosocial concomitants can provide an important base for educational interventions aimed at reducing further transmission. This study aims to provide baseline information on knowledge, attitudes and reported behaviour, relating to HIV/AIDS, among adolescents in KwaZulu-Natal. A survey, using an anonymous, self-administered questionnaire with closed-ended questions to collect data, was conducted among standard eight Zulu-speaking students (N = 1511) in five parts of the province. The theoretical framework that informed data collection was drawn from the Health Belief Model and Bandura's Social Cognitive Theory. The data generated were first analysed descriptively, providing percentages for responses to individual items. Secondly, cross-tabulations were calculated for relevant items using three independent biographical variables, namely: Locality (rural/peri-urban), gender and students' reports of sexual activity. The results showed inadequate knowledge concerning HIV/AIDS to provide a foundation for developing healthier attitudes. Although most students acknowledged the disease's severity, few reported feeling personally susceptible, denying the immediacy of the threat. Additionally, cues to action and the perceived benefits of adopting preventive behaviours were not influential. Barriers preventing condom use were not primarily logistical, with personal concerns being the main barriers to change. Furthermore, perceived self-efficacy in preventive behaviours was low. Recommendations regarding areas for future research, as well as considerations which will enhance the effectiveness of risk reducing interventions among similar populations, are provided.

Many studies have been carried out on Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS). Despite these giant stride (HIV) and (AIDS) have remained a great threat to human existence across the globe. Studies have shown that South Africa has the largest number of people with (HIV) and (AIDS) in Southern Africa. This study examined the factors influencing the implementation of (HIV) and (AIDS) A quantitative research design was adopted in the study. Two hundred and fifty nine subjects were involved in the study (259) this consisted of the University of Fort Hare Alice Campus in Eastern Cape Province. Five hypotheses were generated and tested in the study at 0.05 alpha levels. This study made use of descriptive and hypothesis testing analysis. Descriptive statistics such as the mean, mode, median and the frequency distribution graphs were also used. The study also revealed that there are factors influencing the implementation of HIV/AIDS awareness Programmes at the university of Fort Hare Alice campus F = 9.233, df = 4, 247 and p-value = 0.000, The University of Fort Hare do effectively implement HIV/AIDS policies and programmes. F = 10.765, df = 4, 247 and p-value = 0.000 . There are factors affecting the implementation of HIV/AIDS policies and programmes at university of Fort Hare Alice campus F = 2.207, df = 4, 247 and p-value = 0.069, There are significant difference on the factors affecting the implementation of HIV/AIDS policies and programmes within university Fort Hare Alice campus Chi-square statistic test: = 84.035, df= 16 and p-value = 0.000 (Pearson Chi-square), There are ways to improving the implementation of HIV/AIDS policies and programmes in university of Fort Hare Alice campus. F = 9.233, df = 4, 247 and p-value = 0.000, However, this study recommended that there is need to review the existing policy on (HIV) and (AIDS), the incorporation of (HIV) and (AIDS) awareness programme in the first year curriculum.

M.Cur. / During the time as an infection control professional, there was close contact with patients with Acquired Immunodeficiency Syndrome (AIDS). During this contact period many needs regarding health support were identified. Discrimination and the testing of patients for Human Immunodificiency virus anti·bodies (HIV) without their permission, were the main problem areas. The purpose of the study was to determine the nature and extent of comprehensive health care services for patients with AIDS. The research design is a contextual, exploring and descriptive study. This study was done in the Northern half of economic development area H where 16 health care services were identified. These include clinics, community hospitals, regional- and academic hospitals and the local authority clinic. Private hospitals were not included in the study. Criteria for the nature and extent of comprehensive health care services were based on literature studies. Data was collected by means of structured interviews with nursing professionals in the employ of identified services and patients making use of those services. The results of the research showed various needs in the nature and extent of the comprehensive health care services of the patients with AIDS In order to improve the health care services, recommendations were made and guidelines given to nursing professionals. Recommendations were also made regarding other aspects of the multi·disciplinary team approach. Based upon this study other topics were identified to enable the health care services to provide health care to the patient with AIDS.

The aim of this research was to provide a preliminary investigation of how the HIV and AIDS epidemic will impact on management of municipalities, specifically George Municipality. Municipalities provide a large proportion of essential basic services and also represent one of the primary opportunities for public participation and decision-making at a community level. This paper takes George Municipality in the Western Cape as a case study of the current and potential impact of HIV and AIDS on public demand for services and on the municipality's capacity to govern and provide services. It also reviews the responses of the municipality to HIV and AIDS.The research was conducted using a questionnaire which was distributed to municipal officials in the different departments but also included a review of relevant literature and analysis of quantitative data. The study focused on a single case: An investigation into the impact of HIV and AIDS on municipal management of George Municipality. The study identified strategies utilised by the municipality to reduce the impact of HIV and AIDS. The study drew on people's experiences, perceptions and interpretations of the impact of HIV and AIDS on municipal management, responses and any other related factors that may have impeded the realisation of the reduction of the impact of HIV and AIDS on municipal management in the George Municipality.Fifty questionnaires were distributed, 40 copies by hand delivery and ten copies via e-mail to employees ranging from general worker to senior management. Employees participated in the study through interviews and answering of the questionnaires. An internet search was also conducted using Wed Crawler and by visiting the official website of the George Municipality for all policies, minutes, reports and all other relevant documents regarding HIV and AIDS. The researcher also drew on personal observations because she has been in George for almost six years and is also employed by George Municipality. Participants who were selected by the researcher for interviews purposes were five councillors and five ward committee members because councillors are decision makers in the municipality. The rest were given questionnaires to complete. Data was analysed by using interpretation analysis, namely codes to explain data collected. Results were presented in the form of tables and conclusions warranted by the data are presented. Statistical analysis was done to check correlation between the different aspects in the questionnaire. According to the research findings it can be confirmed that more of the budget needs to be allocated for employment of suitably qualified persons like occupational nurses, who will drive HIV and AIDS education and awareness campaigns. HIV and AIDS mainstreaming should be regarded as a priority in order make people aware about the realities of HIV and AIDS in communities. Leadership and management buy-in should be obtained to win the fight against the epidemic. A comprehensive strategy should be compiled and implemented to reduce the spread and stigma of HIV and AIDS. Proper planning should be done for compiling the strategy. This strategy should specify the budget for HIV and AIDS and how HIV and AIDS is going to be integrated into an IDP. Prevention and management strategies used by the organisation should be explained.

The effects of gender and age on the behavioral risk of HIV/AIDS are not clearly understood as previous distinct studies which have been carried out, have given disputable and contradictory outcomes. This study therefore, discusses the statistical methods which can be used to model the influence of age and gender on the behavioral risk factors of HIV/AIDS. In general, generalized linear models are the main methods which can be applied to depict the impact of age and gender on the behavioral risk of becoming infected with HIV/AIDS virus. In this study, the main methods used were logistic regression, log-linear regression and multiple regressions. Behavioral risk was taken as the dependent variable while age, gender, number of sexual partners, religious beliefs and alcohol and drug abuse were fitted as predictor variables. The three statistical methods gave significant results for gender and insignificant results for age. Furthermore, comparisons were made on the three regression methods and the logistic regression gave the best results. It was therefore concluded that gender plays a significant role on the behavioral risk of HIV/AIDS. The results of the study showed that gender of the student and number of sexual partners had a significant effect on the risk behavior of the university students. In future, it may be very important to find out why age is not a significant factor on risk behavior of HIV/AIDS among university students.

Thesis (MTech: Nursing)-Durban Institute of Technology, 2005 xi, 278, cxxx leaves : ill. ; 30 cm / The study was a cross sectional descriptive approach using individual interviews and a focus group. The study took place in Inanda, KwaZulu Natal. The purpose of the study was to assess the Bhambayi community at the individual, family and community levels in terms of the provision of home-based care for people living with, and affected by AIDS; and to develop an action plan for an appropriate intervention.