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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Bioconjugation strategies through thiol-alkylation of peptides and proteins

Kantner, Terrence January 2015 (has links)
Bioconjugation chemistry generally refers to the covalent derivatisation of biomolecules. Derivatisation of cysteine’s thiol of peptides and proteins is a common method in bioconjugation chemistry as the thiolate is an excellent nucleophile in aqueous conditions. The propensity for thiols to oxidise in an aqueous environment necessitates the need for a disulfide reduction step prior to the addition of ligands derivatised with thiol alkylating linkers. Disulfide reducing agents such as tris(2-carboxyethyl)phosphine (TCEP) and tris(3-hydroxypropyl)phosphine (THPP) are disulfide reducing agents that are often marketed as being non-reactive with thiol alkylating reagents. The reaction of TCEP and THPP with thiol alkylation linkers was therefore investigated. Characterisation of reaction products and mechanistic studies revealed that TCEP and THPP both react with thiol alkylation reagents. A novel protocol was, therefore, developed utilising the Staudinger reaction to oxidise excess TCEP and THPP prior to the addition of thiol alkylating reagents. The protocol offers a simple “one-pot” method for effecting conjugate production via thiol alkylation, without the need for an intermediate purification step for the removal of excess disulfide reducing agents. 4-Vinyl pyridine (4-VP) derivatives were developed and explored as an alternative Michael acceptor class for thiol alkylation of peptides and proteins. The 4-VP derivatives exhibited high reactivity and specificity for thiol alkylation between pH = 7 and pH = 8. A selection of 4-VP linkers were subsequently functionalised with either carbohydrates or polyethylene glycol (PEG) and successfully utilised to produce peptide or protein conjugates via thiol alkylation reactions.

Stereospecific alkynylation at the more hindered carbon of trisubstituted epoxides and concise syntheses of bis-THF acetogenins and analogues

Zhao, Hongda, January 1900 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2006. / Vita. Includes bibliographical references.

An enantioselective total synthesis of tremulenediol A and tremulenolide A and development of the [Rh(CO)₂Cl]₂-catalyzed direct, stereoselective allylic alkylation of unsymmetrical substrates

Ashfeld, Brandon Lee 28 August 2008 (has links)
Not available / text

Stereospecific alkynylation at the more hindered carbon of trisubstituted epoxides and concise syntheses of bis-THF acetogenins and analogues

Zhao, Hongda 28 August 2008 (has links)
Not available / text

Stereoselective alkylation and reduction reactions involving selected cyclic ketones : a study in three parts

Oliver, J. P. (John Paul) 08 1900 (has links)
No description available.

Hydrometallation of alkenes with magnesium alkyls and hydrides catalyzed by bis(cyclopentadienyl)titanium dichloride

Ainslie, Richard Dayle 05 1900 (has links)
No description available.

Part I, Interrupted Nazarov cyclization on silica gel: Part II, Tandem alkylation-cyclization process via an O,C dianion

Dhoro, Francis January 2006 (has links)
Thesis (M.S.)--University of Hawaii at Manoa, 2006. / Includes bibliographical references (p. 63). / xi, 101 leaves, bound ill. 29 cm

Regiocontrol in the Heck-reaction and fast fluorous chemistry /

Olofsson, Kristofer, January 1900 (has links)
Diss. (sammanfattning) Uppsala : Univ, 2001. / Härtill 4 uppsatser.

Alkylation aliphatique sur solide acide /

Latieule, Sylvie. January 1900 (has links)
Th. univ.--Sci. pétrolières, spécialité Chimie--Paris 6, 1994. / Diplôme délivré en association avec l'Ecole nationale supérieure du pétrole et des moteurs. 1995 d'après la déclaration de dépôt légal. Bibliogr. p. 179-187. Résumé en français et en anglais.

The stereochemistry of alkylation of allylic alcohol derivatives with lithium dimethylcuprate and lithium heteromethylcuprates ; On the solvolysis of 2-cyclohexenyl 3,5-dinitrobenzoate and p-nitrobenzoate in aqueous acetone. Introduction of acyl-oxygen cleavage by basic buffer systems

Kantner, Steven Shepard. January 1982 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1982. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 261-272).

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