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The second enzyme of histidine biosynthesis from Arabidopsis thalianaCampbell, Samantha Alison January 1999 (has links)
No description available.
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Chemistry of 4-azalysine and its derivativesMahajan, Anju January 2000 (has links)
No description available.
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Synthesis of a #NU#, #NU#'-dialkyl piperazine #NU#, #NU#,-dioxide #bait and switch' hapten for proteolytic antibodiesNuma, Mehdi Michel Djamel January 2002 (has links)
No description available.
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Synthetic applications of morpholinone templatesCurrie, G. S. January 1996 (has links)
No description available.
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A Study of Synthesis and Stereoisomerism of some Complex Cobalt CompoundsYuan, Daniel T. N. 01 1900 (has links)
The purpose of this investigation is two-fold. Some new complex compounds, where one of the bidentate molecules is an optically active amino acid, were prepared, and attempts to separate those complex isomers by different methods were made. The replacement of the amino acids by optically inactive ligands was studied.
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Robust sequence alignment using evolutionary rates coupled with an amino acid substitution matrixNdhlovu, Andrew January 2014 (has links)
Selective pressures at the DNA level shape genes into pro les consisting of patterns of
rapidly evolving sites and sites withstanding change. These pro les remain detectable
even when protein sequences become extensively diverged. It has been hypothesised
that these patterns can be used as gene identi ers. A common task in molecular biology
is to infer functional, structural or evolutionary relationships by querying a database
using an algorithm. However, problems arise when sequence similarity is low.
The problem is that the algorithm produces numerous
false positives when highly conserved datasets are aligned. To increase the
sensitivity of the algorithm, the evolutionary rate based approach was reimplemented
and coupled with a conventional BLOSUM substitution matrix to produce a new implementation
called BLOSUM-FIRE. The two approaches are combined in a dynamic
scoring function, which uses the selective pressure to score aligned residues. Analysis
of quality of alignments produced, revealed that the new implementation of the FIRE
algorithm performs as well as conventional algorithms. In addition, the Evolutionary
rate Database (EvoDB), which is a compilation of evolutionary rate pro les of all the
members of the PFAM-A protein domain database has been developed. The EvoDB
database can be queried using FIRE to infer protein domain functions. The utility
of this algorithm and database was tested by inferring the domain functions of the
Hepatitis B X protein. Results show that the BLOSUM-FIRE algorithm was able
to accurately identify the domain function of HBx as a trans-activation protein using
EvoDB. The biological relevance
of these results was not validated and requires further interrogation; however, these
proteins share vital roles in viral replication. This study demonstrates the utility
of an evolutionary rate based approach and demonstrates that such an approach is
robust when coupled with an amino acid substitution matrix yielding results comparable
to conventional algorithms. EvoDB is a catalogue of the evolutionary rate
pro les and provides the corresponding phylogenetic trees, PFAM-A alignments and
annotated accession identi er data. The BLOSUM-FIRE software and user manual
including the EvoDB
at le database and release notes have been made freely available
at www.bioinf.wits.ac.za/software/fire. The BLOSUM-FIRE algorithm and
EvoDB database present a tier of information untapped by current databases and tools. / A dissertation submitted to the Faculty of Health Sciences, University of the
Witwatersrand, Johannesburg, in ful lment of the requirements of the degree
of
Master of Science (Medicine).
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Signal peptide prediction in the space-frequency domainLi, Ran. January 2006 (has links)
Thesis (M.E.E.)--University of Delaware, 2006. / Principal faculty advisor: Javier Garcia-Frias, Dept. of Electrical and Computer Engineering. Includes bibliographical references.
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Quantitative Characterization of Hydration of Amino Acids with Solid State NMRLu, Kuo-Jung 14 August 2007 (has links)
none
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Hydration of Amino Acids Investigated by NMR SpectroscopyWang, Hui-Chun 25 August 2003 (has links)
none
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Synthetic and metabolic studies with stereospecifically labelled aspartic acidMahoney, A. January 1984 (has links)
No description available.
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