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Chemical modification, mutagenesis and characterisation of the glycerol dehydrogenase from Bacillus stearothermophilusPaine, Lisa Jane January 1992 (has links)
No description available.
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The genetic manipulation of Bacillus subtilis to lysine overproductionBrazier, P. January 1987 (has links)
No description available.
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Solute transport and intracellular pH in intestinal epithelial cellsArmstrong, Gillian January 1996 (has links)
No description available.
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Aspects of serotonergic and glutamatergic neurotransmission in the human motor system and in motor neurone diseaseForrest, Vanessa Ann January 1996 (has links)
No description available.
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Ileal digestability of pig dietsJagger, S. January 1987 (has links)
No description available.
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The methionine and cystine requirements of growing pigsFerrier, L. J. January 1988 (has links)
No description available.
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Glutathion synthetase in Arabidopsis thalianaRawlins, Marion Ruth January 1998 (has links)
No description available.
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A synthetic and computational investigation of pentacycloundecane amino acid derivatives.Mdluli, Phumlane Selby. January 2005 (has links)
Computational studies have shown that cage skeletons (7) have the tendency to impose a 310-helix as well as an áL-helix on the polypepeptide chain. Residues such as 7 are the useful tools for study of the conformational preferences of peptide models, the design of peptide analogues with improved pharmacokinetics profiles and the development of pharmacophore models. Synthesis of pentacycloundecane amino acid analogue suitable for peptide synthesis would enable us to verify the computational predictions and to contribute to this very active field of research. The sterically hindered 8-amino-pentacyclo[5.4.0.02,6.03,10.05,9]undecane-8-carboxylic acid (7) was synthesised by hydrolysis of the novel bis-Boc protected pentacycloundecane-hydantoin (30). Progress to incorporate 7 into a non-natural peptides is reported. A computational investigation on the regioselective acetylation of hydantoin derivatives which includes PCU hydantoin, 5.5-dimethylhydantoin and 5-methylhydantoin is also reported. The results of the computational investigation initiated the regioselective synthesis of the mono-Boc and bis-Boc derivatives of 5,5-dimethylhydantoin and 5-methylhydantoin. These compounds have not been reported before. / Thesis (M.Sc.)-University of KwaZulu-Natal, 2005.
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Nutritional sensitivity of periparturient breakdown of immunity to gastrointestinal nematode parasites in mammalsSakkas, Panagiotis January 2012 (has links)
Mammals usually develop immunity to gastrointestinal nematode parasites. However, during late pregnancy and lactation, this immunity often breaks down, resulting in elevated levels of parasitism. This periparturient relaxation of immunity (PPRI) renders lactating hosts main sources of infection for their parasite-naïve offspring, and may have a nutritional basis. Results of studies on parasitized hosts suggest that both crude protein (CP) and metabolizable energy (ME) supply may be important in regulating the degree of PPRI by affecting the immune response towards parasites. However there is a scarcity of data supporting such a role for ME in periparturient hosts, while there is sufficient evidence to support the view that CP in general, and amino acids are potent immunonutrients in various disease states (Chapter 1). In the first experiment (Chapter 2) I seperated effects of CP and ME on PPRI by feeding parasitized lactating rats at two levels of ME supply and one of three levels of CP supply. The results show that PPRI is sensitive to CP scarcity, and not to moderate ME scarcity. Increasing CP supply improved lactational performance and reduced PPRI, as observed by reduced worm burdens. In the second experiment (Chapter 3) I examined the rate at which improved nutrition can restore immunity by feeding low protein diets to rats nursing high number of pups, and then reduced litter size in a sub-group so that host nutritional status would change from scarce to adequate. The egg production of the parasite population of the latter group reduced within days to similarly low levels as rats that had always reared low number of pups and this was associated with an increased number of musosal mast cells and increased dam weight gain. Since host responses to dietary CP are almost by ii definition responses to essential amino acids, the third experiment assessed the sensitivity of PPRI to methionine and leucine deficiency (Chapter 4). The latter resulted in increased worm burdens and egg production to similar levels when low protein diets are fed and imposed penalties in lactational performance. Finally, in the fourth experiment it was investigated whether similar outcomes can be expected in periparturient ruminant hosts by supplementing sheep with field beans, which are deficient in methionine, instead of soybean meal (Chapter 5). Indeed, feeding high protein diets based on field beans was less effective in reducing the worm egg excretion and improving lactational performance. The data from this thesis (Chapter 6) provide novel information on the nutritional basis of PPRI, showing that the latter can be rapidly reduced through improved protein nutrition. This may be seen as a response to the protein quality of the diet and the supply of amino acids in optimum quantities. These results have implications for parasite control strategies in farm animals.
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Synthesis of 1-Amino-2-Hydroxycyclopentanecarboxylic AcidHuddle, John David 12 1900 (has links)
This investigation involved the synthesis of 1-amino-2-hydroxycyclopentanecarboxylic acid, a potential structural analog of the natural amino acids, serine and threonine. The title compound also includes the structural features present in an established antitumor agent, cycloleucine.
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