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Therapeutic manipulation of inflammatory mediators / by David R. Haynes.Haynes, David R. (David Robert) January 1993 (has links)
Bibliography: leaves 87-117. / vii, 117, [64] leaves, [8] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Indicates that PGE's and CsA may have similar modes of action. Findings suggest that therapies that selectively subpopulations of leucocytes, and manipulate the inflammatory mediators they produce, may be effective in the treatment of chronic immuno-inflammatory diseases similar to rheumatioid arthritis. / Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 1994?
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Bioequivalence studies of ketoprofen : product formulation, pharmacokinetics, deconvolution, and in vitro - in vivo correlationsHolt, Kris Edward 20 August 1997 (has links)
This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a spray coating apparatus. Ketoprofen beads manufactured in this manner will immediately release their drug content in either an in vitro or an in vivo environment. Industrially produced beads were non-homogeneous in size. Large beads in a coating batch sweep up a disproportional amount of coating material leading to a thicker coating layer and decreased drug release rates. In order to predict the effects of coating modifications, an equation was developed to accurately predict the coating thickness of any material applied to spherical particles of any size. The equation developed is suggested as a replacement for one that has been in published and cited for over 20 years, but overestimates
coating thickness.
The bulk of this thesis details the process of altering the drug release
characteristics of the beads through application of diffusional and enteric barrier coatings, and testing for bioequivalence with Oruvail through biostudy data gathered from human volunteers. Urinary drug excretion rates were measured as a substitute for timed blood sampling of the subjects. Validity of the substitution was shown. Fed state biostudies involved beads manufactured and coated at Oregon State University. Fasted state biostudies involved beads that were industrially manufactured in a scale-up operation and coated both industrially and at Oregon State University.
Deconvolution, a mathematical tool, was used to determine in vivo dissolution rates and the need for further coating modification. Statistical testing using a Two 1-Sided T test was the final arbiter of whether or not bioequivalence
was concluded. Bioequivalence was achieved in subjects under a fed state and finally under fasting conditions, as required by the Food and Drug Administration, with drug beads coated with ethylcellulose to slow drug release and overcoated with an enteric bather to retard early drug release.
Deconvolved in vivo dissolutions originating from biostudy data were used to develop In Vitro / In Vivo Correlations (IVIVC's). IVIVC's were used to predict in vivo biostudy data from in vitro dissolution results following coating formulation modification. A practical guide for the development and use of an IVIVC was written for pharmaceutics practitioners who have an understanding of pharmacokinetics, but may lack sufficient expertise in pharmacokinetics to develop
an IVIVC. / Graduation date: 1998
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Role of Helicobacter pylori and non-steroidal anti-inflammatory drugs in prevention of gastric cancerWong, Chun-yu, Benjamin. January 2005 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.
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Helicobacter pylori and non-steroidal anti-inflammatory drugs in gastric carcinogenesisGu, Qing, January 2006 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.
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The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery /Van Eeden, Simon Peter, January 2000 (has links)
Thesis (MChD(Chir. Max. Fac.-Med.))--Universiteit van Pretoria, 2000. / Also available online.
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Biological activity of nanostructured silverNadworny, Patricia L. January 2010 (has links)
Thesis (Ph.D.)--University of Alberta, 2010. / A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Chemical and Materials Engineering, Medical Sciences - Biomedical Engineering. Title from pdf file main screen (viewed on January 30, 2010). Includes bibliographical references.
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Development of anti-inflammatory agents from the aromatic plants, Origanum spp. and Mentha spp., and analytical methods on the quality control of bioactive phenolic compoundsShen, Diandian. January 2008 (has links)
Thesis (Ph. D.)--Rutgers University, 2008. / "Graduate Program in Medicinal Chemistry." Includes bibliographical references.
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Ethnopharmacological and phytochemical investigation of Melicope species from Réunion Island /Toft Simonsen, Henrik. January 2002 (has links)
Ph.d.
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A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-inducedgastrointestinal effectsChak, Man-lee, Charlotta., 翟敏莉. January 2004 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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The effect of anti-inflammatory agents on pyruvic acid formation in tissue homogenatesMullen, Theodore Richard, 1923- January 1956 (has links)
No description available.
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