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Thesis (Ph.D.) -- University of Adelaide, Dept. of Physiology, 2000. / Includes bibliographical references (21 leaves).

published_or_final_version / Medical Sciences / Master / Master of Medical Sciences

Includes bibliographical references (21 leaves). Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemic rabbit and ascertain if this effect was due to an increase in the LDL receptor. The study provides evidence that green tea and its catechins exhibit hypocholesterolaemic properties and may therefore provide protection against heart disease.

Includes bibliographical references (21 leaves). / 1 v. (various pagings) : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemic rabbit and ascertain if this effect was due to an increase in the LDL receptor. The study provides evidence that green tea and its catechins exhibit hypocholesterolaemic properties and may therefore provide protection against heart disease. / Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 2000

Thesis (M. Med. Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 44-50).

The cholesterol-lowering efficacy of the original sugarcane-derived Cuban policosanol (OPC) supplement has been attributed to an exclusive policosanol purity and composition. The first objective of the following study was to compare the purity and composition of the OPC and alternative sugarcane derived policosanol (APC) products. Second, to measure blood lipids and policosanol levels in tissues, plasma and feces in hamsters receiving diet fortified with no policosanols, OPC, or an APC (APC1) product. Results indicated that the policosanol purity and composition of the OPC and APC formulations are similar. Lipid levels were not significantly different between groups. Policosanols were undetectable in the plasma and tissues of any animals following policosanol supplementation. Policosanols were excreted at a higher rate in animals consuming APC1. Sugarcane-derived policosanols are not an efficacious cholesterol-lowering therapy. The purity and relative percent composition of the OPC supplement cannot account for its efficacy as a lipid lowering agent.

Thesis (M.Med.Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 44-50) Also available in print.

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