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Mechanisms of accumulation and biological consequences of polynuclear platinum compounds /Kabolizadeh, Peyman, January 2007 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for: Dept. of Chemistry. Bibliography: leaves 217-221. Also available online via the Internet.
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Structural studies of tumor inhibitors of plant originAnderson, Wayne Keith, January 1968 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1968. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Design and synthesis of axial chiral anthracenes : in search of novel anti-tumor chemotherapeutics /Rider, Kevin C. January 1900 (has links)
Thesis (Ph. D.)--University of Idaho, 2005. / Also available online in PDF format. Abstract. "November 2005." Includes bibliographical references.
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Synthesis of DEF ring synthons to nogarol anthracyclines /Ellenberger, William Paul, January 1987 (has links)
Thesis (Ph. D.)--Oregon Graduate Center, 1987.
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S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), water soluble garlic derivatives, suppress growth and invasion of androgen-independent prostate cancer, under in vitro and in vivo conditions /Chu, Qingjun. January 2006 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Also available online.
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Studies of the antitumor activity of [alpha]-TEA in human breast cancer cellsWang, Pei, January 1900 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2006. / Vita. Includes bibliographical references.
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Anti-tumor properties of CD40 ligand when delivered as a transgene by the conditional replicative oncolytic adenovirus AdEH to breast cancer cellsGomes, Erica Manuela. Tong, Alex W. January 2006 (has links)
Thesis (Ph.D.)--Baylor University, 2006. / Includes bibliographical references (p. 116-137).
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Synthetic studies of naturally occurring hydroxylated polycyclic compounds : daunomycinone and pillaromycinone /Baghdanov, Vaceli M., January 1987 (has links)
Thesis (Ph. D.)--Oregon Graduate Center, 1987.
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Transition metals as anti-tumoral agents : some structure-function relationships of the platinum group metals /Flynn, Allison, January 1994 (has links)
Report (M.S.)--Virginia Polytechnic Institute and State University, 1994. / Vita. Abstract. Includes bibliographical references (leaves 53-61). Also available via the Internet.
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Exploring alternative cytotoxic strategies for cancer treatmentZhu, Yanting 31 July 2014 (has links)
Triggering direct cytotoxicity has been the most common strategy for developing cancer treatments. The cytotoxic regimens currently used in the clinic mainly include radiation therapy, classic chemotherapeutic drugs (e.g. DNA damaging drugs and anti-mitotic drugs) and selected new targeted drugs. Although these therapies are the standard of care for most cancer patients, they suffer significant limitations: responses to these therapies vary significantly between cancer types and patients; sensitive cancers tend to acquire resistance; and they cause serious toxicity, particularly to dividing cells in the bone marrow and gut, and to neurons. It is not clear whether major improvements in cytotoxic anticancer therapies are possible; if they are, progress is likely to come from either new methods for identifying sub-populations of patients that respond well to current drugs, or developing new therapies with novel cytotoxic mechanisms. To pursue the above two avenues towards potential improvement of cytotoxic therapies, this thesis investigates: biomarkers that determine the sensitivity of distinct cancer cell types to common anti-mitotic chemotherapeutics; and the mechanistic basis to employ alternating electric field and Natural Killer cells as alternative methods to trigger cancer cell death. The study uses time-lapse microscopy as the major technique to characterize and quantify response dynamics to the different cytotoxic treatments, and the results provide important new insight not only for understanding existing cytotoxic anticancer drugs but also for developing novel cytotoxic regimens.
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