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1	Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons Landry, Richard Spencer, Jr. 20 January 2006 (has links) A computational model of a midbrain dopamine neuron was extended in this study to include a response to random excitatory afferent input by incorporating the receptor components AMPA and NMDA. In a diagonal band where average glutamatergic and tonic gabaergic input is roughly balanced, both single spike firing and bursting can be observed. Simulated SK channel block strengthens the correlation between pattern and rate and increases the number of spikes fired in bursts by increasing the spikes per burst. A simulated doubling of the AMPA/NMDA ratio leads to a frequency increase that becomes more prominent at high firing rates, and an increase in the percent spikes fired in bursts. Changes in pattern and rate are poorly correlated in the model. Manipulations of the neuron greatly depend on the background level of synaptic inputs, suggesting that interpretation of population data from dopamine neurons requires taking variability into account rather than averages. DA neurons Single spike firing and burst firing Apamin Bursting rate
2	Regulation of the motor output of the spinal cord: burst firing generation and sensorimotor integration Mahrous, Amr A. 01 May 2018 (has links) No description available. Neurosciences Physiology Biomedical Research Cellular Biology Spinal Cord Motoneurons Motor Output Rhythmic Activity Neuronal Bursting Fictive Locomotion SK Channels Apamin Methoxamine Synaptic Plasticity Sensorimotor Integration Synaptic Integration Neuromodulatory State

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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons

Regulation of the motor output of the spinal cord: burst firing generation and sensorimotor integration