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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
441

The isolation, identification and characterisation of bioactive compounds from plants used in traditional medicine

Mackenzie, Fiona L. January 1998 (has links)
No description available.
442

The Protective Role of Epidermal Growth Factor in Neonatal Necrotizing Enterocolitis

Clark, Jessica Ann January 2006 (has links)
Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal disease in premature babies. Despite significant morbidity and mortality, the cause of this disease remains unclear and there are no preventative treatments available. Prematurity and enteral feeding of infant formula are considered to be the primary risk factors for development of NEC. Interestingly, the incidence of NEC is six to ten times lower in breast-fed babies compared to those that were formula-fed. The factors responsible for the protective effect of breast milk against NEC have not been identified, but epidermal growth factor (EGF) is one of the most promising candidates. EGF is found at high concentrations in human milk, but is not present in any commercial formula. Mothers with extremely premature babies have 50-80% higher levels of EGF in their breast milk compared to mothers with full term infants. This suggests that EGF plays an important role in the development of premature infants. Our studies have shown that supplementation of EGF into formula significantly reduces the incidence of NEC in a neonatal rat model. However, the mechanisms underlying this EGF-mediated reduction of NEC are not understood. The overall hypothesis of this dissertation is that the protective effect of EGF in NEC pathogenesis is mediated via increased expression of pro-survival genes and strengthening of the mucosal barrier. The results of the studies within this dissertation demonstrate that treatment with EGF significantly decreases intestinal epithelial cell apoptosis at the site of NEC injury by up-regulating anti-apoptotic genes and down-regulating pro-apoptotic genes. Furthermore, supplementation of formula with EGF strengthens the mucosal barrier by inducing accelerated maturation of ileal goblet cells and mucin-2 production. In addition, EGF treatment normalizes expression of crucial tight junction proteins in the ileum. Consequently, EGF treatment results in a significant decrease in intestinal paracellular permeability and improved barrier function. Results from these studies will provide significant contributions to the understanding of EGF-mediated reduction of NEC, which may lead to development of therapeutic strategies for the treatment of human NEC.
443

The immediate-early response of fibroblasts to serum deprivation

Hancock, David Christopher January 1997 (has links)
No description available.
444

Clearance of dying cells by antigen presenting and scavenger phagocytes : implications for autoimmunity and tolerance

Rovere Querini, Patrizia January 2000 (has links)
No description available.
445

New aspects of the cellular effects of paracetamol and related antioxidants

Wong, Weng Sie January 2000 (has links)
No description available.
446

The evaluation of p53 function in cells from members of cancer prone families

Lomax, Martine Elizabeth January 1998 (has links)
No description available.
447

Growth factor modulation of cytokine-mediated cell death and Fas expression in insulin-containing cells

Harrison, Moira Joan January 2000 (has links)
No description available.
448

The role of iron in the aetiology of colon cancer

Lund, Elizabeth Kay January 1999 (has links)
No description available.
449

Mechanisms of cell death in cerebellar granule neurones

Singh, Shweta January 2001 (has links)
No description available.
450

The role of P53 in platinum anticancer drug sensitivity

Pestell, Katharine Elizabeth January 1999 (has links)
No description available.

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