We construct a theory of general boundary value problems for differential operators whose symbols do not necessarily satisfy the Atiyah-Bott condition [3] of vanishing of the corresponding obstruction. A condition for these problems to be Fredholm is introduced and the corresponding finiteness theorems are proved.

We give the homotopy classification and compute the index of boundary value problems for elliptic equations. The classical case of operators that satisfy the Atiyah-Bott condition is studied first. We also consider the general case of boundary value problems for operators that do not necessarily satisfy the Atiyah-Bott condition.

We construct a new calculus of boundary value problems with the transmission property on a non-compact smooth manifold with boundary and conical exits to infinity. The symbols are classical both in covariables and variables. The operators are determined by principal symbol tuples modulo operators of lower orders and weights (such remainders are compact in weighted Sobolev spaces). We develop the concept of ellipticity, construct parametrices within the algebra and obtain the Fredholm property. For the existence of Shapiro-Lopatinskij elliptic boundary conditions to a given elliptic operator we prove an analogue of the Atiyah-Bott condition.