by Tse Si-yin John. / Bibliography: leaves 73-74 / Thesis (M.B.A.)--Chinese University of Hong Kong, 1985

Thesis (Ph. D.)--Virginia Commonwealth University, 2006. / Prepared for: Dept. of Health Administration. Bibliography: leaves 157-165. Also available online via the Internet.

Developing a new drug costs up to US$2.6B and 13.5 years. To save money and time, we have developed a toolset for computer-aided drug discovery, and utilized our toolset to discover drugs for the treatment of cancers and influenza. / We first implemented a fast protein-ligand docking tool called idock, and obtained a substantial speedup over a popular counterpart. To facilitate the large-scale use of idock, we designed a heterogeneous web platform called istar, and collected a huge database of more than 23 million small molecules. To elucidate molecular interactions in web, we developed an interactive visualizer called iview. To synthesize novel compounds, we developed a fragment-based drug design tool called iSyn. To improve the predictive accuracy of binding affinity, we exploited the machine learning technique random forest to re-score both crystal and docked poses. To identify structurally similar compounds, we ported the ultrafast shape recognition algorithms to istar. All these tools are free and open source. / We applied our novel toolset to real world drug discovery. We repurposed anti-acne drug adapalene for the treatment of human colon cancer, and identified potential inhibitors of influenza viral proteins. Such new findings could hopefully save human lives. / 開發一種新藥需要多至26億美元和13年半的時間。為節省金錢和時間，我們開發了一套計算機輔助藥物研發工具集，並運用該工具集尋找藥物治療癌症和流感。 / 我們首先實現了一個快速的蛋白與配體對接工具idock，相比一個同類流行軟件獲得了顯著的速度提升。為輔助idock 的大規模使用，我們設計了一個異構網站平台istar，收集了多達兩千三百萬個小分子的大型數據庫。為在網頁展示分子間相互作用，我們開發了一個交互式可視化軟件iview。為生成全新的化合物，我們開發了一個基於分子片段的藥物設計工具iSyn。為改進結合強度預測的精度，我們利用了機器學習技術隨機森林去重新打分晶體及預測構象。為尋找結構相似的化合物，我們移植了超快形狀識別算法至istar。所有這些工俱全是免費和開源。 / 我們應用了此創新工具集至現實世界藥物尋找中。我們發現抗痤瘡藥阿達帕林可用於治療人類結腸癌，亦篩選出流感病毒蛋白的潛在抑制物。這些新發現可望拯救人類生命。 / Li, Hongjian. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2015. / Includes bibliographical references (leaves 340-394). / Abstracts also in Chinese. / Title from PDF title page (viewed on 15, September, 2016). / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only.

by Polly Y. Yuen, Aegidia Y. Wong. / Bibliography: leaves 92-95 / Thesis (M.B.A.)--Chinese University of Hong Kong, 1986

by Leung Chung-poon, Wong Ying-fai. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1988. / Bibliography: leaf 98.

Hu, Xihao. / Thesis Ph.D. Chinese University of Hong Kong 2015. / Includes bibliographical references (leaves 147-161). / Abstracts also in Chinese. / Title from PDF title page (viewed on 26, October, 2016). / Hu, Xihao.

The study examines the use of automatic data processing in educational organisations for the purpose of determining the feasibility of using some ADP applications in the administration of a large urban ACT primary school. Educational managers working in primary schools are required to make decisions which draw upon information concerning the student population, school curriculum, school personnel and general school administration. An analysis of the decision making areas of Charnwood Primary School is undertaken and the information required for making each decision is identified. The concept of using a database to provide some of this information is explored and suggested as being an effective means of managing student data. Some equipment options which would enable a primary school to implement a database and provide word processing facilities are examined within a context of limited resources. The capacities and advantages of using computer equipment which is presently accessible to schools are outlined, along with the feasibility of employing the services of a data processing agency. The conclusion is reached that there are a number of ADP applications applicable for use at Charnwood Primary School, as well as a number of other computer based facilities, such as word processing and plant management, The downward price spiral of computer equipment will enable most primary schools to use computer facilities for school administration within the next five years.

Thesis (Ph. D.)--Virginia Commonwealth University, 2006. / Prepared for: Dept. of Health Administration. Bibliography: leaves 165-173. Also available online.

by Fan Kai Leung. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1993. / Includes bibliographical references (leaves [87-96]). / Abstract / Acknowledgement / Chapter Chapter 1 --- Introduction / Chapter 1.0 --- Foreword / Chapter 1.1 --- Project Objective / Chapter 1.2 --- Historical Background / Chapter 1.3 --- The properties of Radial Pulse Wave-An Engineering View / Chapter 1.4 --- The development in RPW acquisition and research-An Overview / Chapter 1.5 --- Problems to be solved for RPW data acquisition system / Chapter 1.6 --- The contribution of this project / Chapter Chapter 2 --- System Realisation / Chapter 2.0 --- Foreword / Chapter 2.1 --- System Development-An Overview / Chapter Chapter 3 --- Signal Preprocessing Unit / Chapter 3.0 --- Foreword / Chapter 3.1 --- Earlier Methods for offset Cancellation / Chapter 3.2 --- Feedback control of the offset and d.c. transient cancellation / Chapter 3.3 --- The level shifting circuit / Chapter 3.4 --- Amplifier / Chapter 3.6 --- The 50Hz notch filter / Chapter 3.7 --- The 4th order low pass filter / Chapter 3.8 --- Circuit for controlling valves and pump / Chapter Chapter 4 --- Signal Processing for RPW Acquisition / Chapter 4.0 --- Foreword / Chapter 4.1 --- Artefact and signal noise / Motion artefact / Respiratory Artefact / Base line shift due to tissue displacement / Electromagnetic Interference and circuit noise / Chapter 4.2 --- Artefact Correction by the Switch Capacitive Device(MF-6) / Operating principle / Result and Discussion / Chapter 4.3 --- Artefact Correction by Recursive Moving Average(RMA) / The RMA Operation / Software Implementation of RMA / Chapter 4.4 --- Further Improvement of the RMA baseline estimator / Chapter 4.5 --- Signal Noise Suppression by Non-linear filtering / Chapter 4.6 --- An arithmetic cycle detector for RPW and ECG / Chapter Chapter 5 --- The Software for the DAS / Chapter 5.0 --- Foreword / Chapter 5.1 --- The present DAS software / Chapter 5.2 --- The software design / Chapter 5.3 --- Important points about the software / Signal input / Waveform display and smooth scrolling / Dynamic display area allocation / The software FIFO data buffer / Chapter Chapter 6 --- Recapitulation and Topics for Further Investigation / Chapter 6.0 --- Foreword / Chapter 6.1 --- Recapitulations / Objective / Difficulties / System Realisation / Signal Preprocessing Unit / Signal Processing / The software / Chapter 6.2 --- Direction for further investigation / Improvement to the DAS / Data analysis and modelling research / Appendix A The Comparasion of the RMA and SMA Characteristics / Appendix B List of Publications

Kwok, Tsz Piu. / Thesis M.Phil. Chinese University of Hong Kong 2015. / Includes bibliographical references (leaves 109-120). / Abstracts also in Chinese. / Title from PDF title page (viewed on 04, January, 2017).