Worldwide there are 350 million people with chronic hepatitis B infection and globally it causes up to half of the liver cancer deaths and one third of deaths from cirrhosis. Only a fraction of sufferers will develop these complications. Various studies have implicated socio-demographic, biochemical and viral factors in disease progression but research has been limited to local populations in endemic countries. Our aim was to study the prevalence and factors associated with advanced disease of hepatitis B infection in immigrants living in East London. I completed a retrospective analysis of notes and electronic health records of 1209 immigrant patients attending hospitals in East London, 217 of whom were from Bangladesh and Pakistan. Screening of volunteers attending local mosques using oral mucosal transudate swabs and national statistics data allowed us to calculate prevalence rates in these populations. Those 13 patients from Bangladesh and Pakistan admitted over 30 months with decompensated disease were men aged > 40. Age, sex, ALT, smoking, alcohol and diabetes were significant predictors for cirrhosis and decompensated disease but not viral markers. Similar analyses were performed for other ethnicities with similar outcomes. The scale of under diagnosis of hepatitis B for all ethnicities was estimated and the reasons explored. This work has scrutinised the epidemiology of chronic hepatitis B in East London and the difficulties encountered exploring it. We provide differing results to published studies and suggestions for how this domain can be examined further.

In the search for the foundations of cognition philosophers often encounter a familiar problem - the problem of content. The problem of content is essentially the problem of how content, whether experiential or intentional, is possible. In practice providing a response to this problem involves providing an account of how an active self-consciousness is able to conceive/perceive, or in some way be consciousness ofx. The unique nature of this problem imposes significant constraints on the field of explanatory possibilities. Since the x which is to be accounted for is essentially the possibility of absolutely any x there is no y which is not also an x. Hence, nothing remains outside of the explanandum which can be appealed to in order to account for it without, to some extent, presupposing that which needs to be explained. In many of the theories we will examine overcoming this problem involves appealing to a transcendental "structure of awareness" which more often than not is composed of "universal-like" transcendental "entities" of indeterminate nature and ontological status. A major appeal of transcendental entities (e.g., forms, species, essences, pure categories, and dharmas) is that they can at least appear to provide a way of supplying the power of objective "determinateness" necessary to account for the possibility of determination without themselves being determinates (i.e., without presupposing content). The general strategy of appealing to such transcendental "entities" has, however, for some time been suspiciously regarded as it is unclear how such an appeal is able to avoid the aforementioned presupposition of content. But if the appeal to transcendental cognizing intermediates is to be ' dismissed we may be left to face up to the fact that content simply "happens"- that the process of determination, of "judgment", is a mysterious talent that can neither be taught nor understood. Through a critical examination of both Western and Eastern philosophical approaches to the problem of content this dissertation identifies and describes, insofar as is possible, "that" through which content is rendered possible. In so doing it draws attention to previously neglected points of contact between major philosophical traditions and clarifies the central issues surrounding the problem. The dissertation supports the conclusion that, although there is a need to acknowledge a particular role for a transcendental "self- consciousness" in providing a coherent response to the problem of content, the attempt to articulate a mechanism through which this role is fulfilled most likely misguided. Although it appears to be possible both to know something about this "self-consciousness", and even to know it more directly, it cannot be understood in the usual sense.

This thesis analyses Nietzsche's use of eros in The Gay Science through the concepts of passion and eternity. Nietzsche deploys the conceptual resources of the Hellenistic schools, particularly Stoicism and Epicureanism, to articulate an "affirmative" rival to the Platonic sublimation of eros. However, the Stoic and Epicurean therapies prove insufficient remedies for Platonism: in all three cases, Nietzsche diagnoses a pathological fear of transience. Throughout The Gay Science Nietzsche develops an anti-Platonic and, in the end, anti-Hellenistic philosophical therapy. Traditional readings of Nietzsche rightly emphasise his antagonism with Plato, but in doing so overlook the richness of his engagement with later philosophical thought of antiquity. Stoicism provides the starting point for Nietzsche's attempt at an immanent affirmative ethics. Nietzsche comes to reject Stoic indifference as an evacuation of value from the world, but the terms of his rejection shed light on the criteria against which his develops his own ethics. Nietzsche's appraisal of Epicureanism above Stoicism in The Gay Science shows that an intimate relationship with worldly goods is a necessary condition of joy, but the terms of this comparison also exposes the limits of both Hellenistic philosophies: neither is able to evoke and maintain an erotic attachment to life. A reading of Plato's Symposium illuminates Nietzsche's rejection of a metaphysical treatment of eros. The first three chapters of the thesis show the failure of Stoicism (chapter one), Epicureanism (chapter two), and Platonism (chapter three) in forging a strong-enough attachment to what Nietzsche calls life. Chapter four explains Nietzsche's revaluation of the passions by means of a conceptual history of Leidenschaft. Nietzsche's praise of the Provençal troubadours, whose gaya scienza provides The Gay Science's subtitle, demonstrates the possibility of a life-affirming eros. A recuperation of eros requires the renovation of the concept of eternity, which has hitherto functioned as an escape path from transience. Chapter five figures Nietzsche's feud with the ancients in terms of this function of eternity in relation to the fear of death. Each of the three ancient conceptions arises from different refractions of a common fear of transience. The final chapter presents Nietzsche's alternative, anti-Hellenistic ethics of eternity: a youthful and voluptuous art of living. This youthful sensibility must be specified in terms of the eternal recurrence, a conception of eternity developed by Nietzsche in a sustained dialogue with classical and Hellenistic ethical thought. I demonstrate that Nietzsche's engagement with classical and Hellenistic thought feeds directly into the central doctrine of the eternal recurrence. By means of the attention paid to Nietzsche's eternity, the thesis arrives at a richer understanding of Nietzsche's middle-period ethics and of his relationship to antiquity.

I defend the claim that some things genuinely matter to human beings. This involves overcoming a series of arguments which suggest that the things that matter to us are arbitrary. These arguments arise out of Nagel’s claim (in Mortal Questions) that life is absurd. The thesis also discusses different senses in which life can be said to have meaning. I put religious accounts of the meaning of life to one side. Instead, I focus on outlining how someone can experience their own life (and the world) as meaningful. My main aim is to show that some things genuinely matter. I argue that some things genuinely matter from the perspective of the individual in virtue of the fact that they can become conscious of their own needs. So, there are facts about human nature (we are self-consciousness and have needs) that, taken together, show that some things genuinely matter to us (non-arbitrarily). These include our vital needs, our happiness and positive relationships with others. I argue that these things matter to us not simply in virtue of the fact that we happen to think that they matter (although this is certainly true). Rather, they genuinely matter to us given our nature.

Natural disasters are social disruptions triggered by physical events. Every year, hundreds of natural disasters occur and tens of thousands of people are killed as a result. I maintain that everyone would want to be provided with assistance in the aftermath a natural disaster. If a national government is not providing post disaster assistance, then we expect that some other institution has the responsibility to provide it. Unfortunately, that is not the case currently. Therefore, in this thesis I argue that in some situations the international community is required to intervene on behalf of those affected by the disaster caused by a natural hazard. Natural disaster intervention is a moral requirement: because the international community has a duty to provide the goods we are entitled to as per the human right to welfare, even in natural disaster scenarios. After making my argument as to why a natural disaster intervention policy should be developed I explain the basic principles of such a policy by applying the Just War criteria to natural disaster scenarios in which a national government is unable or unwilling to provide assistance to its people.

The main aim of my thesis is to ascertain whether empathy has the required qualities of an emotion. Disagreement is rife regarding the process leading to the arousal of an emotion, which creates uncertainty as to what exactly an emotion is, and how it appears. This is the first issue I tackle in my work, as I concentrate on examining some of the significant cognitive and feeling theories of emotions. My study of these theories outlines their downsides, and I instead propose to retain a hybrid definition that combines the advantages of both families of theories to provide a balanced approach that recognises the importance of both physical changes and cognitions. The focus of my work then moves specifically onto empathy, with the intention of precisely defining this term too, its functioning, as well as the meaning of the expression ‘feeling empathy for someone’. The existing literature on empathy fails to provide a clear understanding of empathy’s classification as an emotion or a skill. My work is original in that I avoid assertions and clearly establish that empathy constitutes an emotion based on the definition of emotion I advance in the first part of my work.

This thesis explores attempts to characterise the structure of reality. Three notions stand out: Lewisian naturalness, Sider’s ‘structure’, and grounding, where the latter has become the most popular way to characterise the structure of reality in the contemporary literature. I argue that none of these notions, as they are currently understood, are suited for limning the metaphysical structure of reality. In the first part of the thesis I argue that, by the lights of the relevant theories, both naturalness and structure fall short of the theoretical role carved out for those posits. In the second part of the thesis I present two challenges to the ‘orthodox’ conception of grounding. The first contests the standard assumption that grounding is asymmetric, both by citing what I take to be best described as symmetric instances of grounding, and by developing and arguing for a new theory of metaphysical structure – ‘metaphysical interdependence’ – which takes grounding to be nonsymmetric. The second challenge concerns the relationship between grounding and (metaphysical) explanation, and leads to a dilemma for the grounding theorist. My proposed resolution to the dilemma is to adopt an antirealist approach to grounding, which I further motivate and develop in the final chapter.

In the penultimate remark of the Tractatus Logico-Philosophicus Wittgenstein declares that anyone who understands him judges the book to be nonsense. The immediate reaction to this paradoxical statement is to reject the insights of the book that this assessment is based on; that is, to reject the book’s theories of logic and language. Commentators have tried to save the book’s fundamental philosophical ideas by blocking this immediate response. In this thesis I characterise and explore different attempts to do so. I discuss attempts of Russell, Carnap, Max Black, Malcolm, Hacker’s Ineffability interpretation and Conant’s (and Diamond’s) Therapeutic interpretation. I argue that the Therapeutic reading is the most promising attempt in its main ideas. Nonetheless, current versions of the Therapeutic readings do not seem successful. I borrow ideas from Grice’s pragmatic theory of conversation and Davidson’s account of metaphor to explain how the book is to be read therapeutically. I argue that the book is a long conversation between Wittgenstein and his audience which eventually turns out to be a pointless series of remarks. The book, however, works metaphorically in such a way that it affects its readers and helps them to divest themselves of the inclination to do philosophy.

According to the doctrine of informed consent medical procedures are morally permissible when a patient has consented to the treatment. Problematically it is possible for a patient to consent to or refuse treatment which consequently leads to a decline in her best interests. Standardly, such conflicts are resolved by prioritising the doctrine of informed consent above the requirement that the medical practitioner acts in accordance with the duty of care. This means that patient free choice is respected regardless as to whether her choice leads to a decline in her best interests, since to disrespect patient choice would be an instance of ‘unwarranted’ paternalism. This thesis defends the claim that in cases where patient consent comes into conflict with her best interests, paternalistic interference is in fact justified. The ambition of the thesis is thus twofold: in the first place I argue that the doctrine of informed consent cannot be used as an ethical guarantor for medical decision making. Secondly I will conclude that hard paternalism is justified in medical practice, thereby calling for a reversal of the prioritisation of informed consent procedures over the medical practitioner’s duty of care.

In this thesis I propose a new way of understanding depressive illness as not exclusively harmful, but as related to particular, empirically evidenced, epistemic and pragmatic benefits for the subject, alongside the associated costs. For each of the benefits considered, I provide and concisely analyse the empirical evidence both in its favour and against it, suggest ways in which these benefits could apply in the circumstances presented, discuss some outstanding problems for that application as stated, and describe potential implications. The issues discussed involve topics in cognitive psychology as well as in ethics, which I regard as complementary to the debate. I take the view that depression related phenomena such as low mood, low self-esteem, and mood-congruent delusions offer potential benefits to a subject under certain circumstances, but not under others. In discussing the hypotheses presented, I argue for a more complex view of depression, which includes its potential epistemic and pragmatic benefits as well as its costs and I propose possible directions for future research.