<p>This study investigated, within the context of Brain Reserve Capacity (BRC) theory, whether repeated concussions resulted in residual deficits in cognitive and academic functioning of early adolescent rugby players relative to non-contact sports controls.</p>

Homologous recombination (HR) is a faithful mechanism for the repair of double-stranded DNA breaks (DSBs) and plays a critical role in maintaining the integrity of genomic DNA. The product of the Breast Cancer Susceptibility 2 (BRCA2) gene functions as a recombination mediator in HR-directed repair of DSBs. BRCA2 interacts directly with RAD51, the central recombinase of HR, through highly conserved repetitive motifs of 30-40 amino acids, named BRC repeats, and regulates the formation of the RAD51-ssDNA nucleoprotein filament. There is significant variability in the number of BRC repeats among taxa. However, all mammalian BRCA2 orthologs have eight BRC repeats, which display different characteristics in in vitro studies of RAD51-ssDNA nucleoprotein filament. To test the importance of the number of BRC repeats and to evaluate the role of individual BRC repeats in HR, BRCA2 variants bearing different combinations of BRC repeats were generated using BAC-recombineering, expressed in murine hybridoma cells, and assayed for the ability to stimulate HR using a gene targeting assay. The BRCA2 variant bearing BRC repeats 1 to 4 decreased the efficiency of HR and increased the level of Rad51 protein, whereas the BRCA2 variant bearing BRC repeats 5 to 8 significantly stimulated HR, but had no effect on the level of Rad51. These results supported the hypothesis that BRC repeats are not functionally equivalent, but rather have different, perhaps reinforcing functions in HR. / Canadian Institutes of Health Research

<p>This study investigated, within the context of Brain Reserve Capacity (BRC) theory, whether repeated concussions resulted in residual deficits in cognitive and academic functioning of early adolescent rugby players relative to non-contact sports controls.</p>

The thesis deals with the issue of compliance processes to ensure safety and quality of food. These standards are embedded in the world's standards, the standards. In the introduction, the author explains the reason for the choice of this topic. Further hypotheses and objectives formulated by the work that have to be met and verified. From the available literature was created glossary topic, where I describe the history of the topic, its evolution and the current status at the present time. In the next chapter the author verifies the formulated hypotheses and meets the objectives of the work, all on the basis of the specified methods. At the conclusion of the work the author confronts the detected results with findings from the available literature, with hypotheses, review, and outlined the future continuation of the thesis.

Philosophiae Doctor - PhD / This study investigated, within the context of Brain Reserve Capacity (BRC) theory, whether repeated concussions resulted in residual deficits in cognitive and academic functioning of early adolescent rugby players relative to non-contact sports controls. / South Africa

No description available.

A Leucemia Mieloide Crônica é uma doença hematopoiética associada a células estaminais que se manifesta principalmente com a expansão mielopoese. O cromossomo Philadelphia positivo PH+ é gerado por uma translocação recíproca (9, 22) (Q34, Q11) e pela fusão entre o gene Abel- son, essa fusáo codifica e desregula á protéına Tirosina Quinase, o suficiente para a iniciação e manutenção da doença. Inibidores como o Mesilato de Imatinibe revolucionou o tratamento de pacientes com leucemia mieloide crônica. As mutaç ões no domínio de quinase do Bcr-Abl, constituindo o mecanismo mais frequente de resistência adquirida para a terapia com inibidores da tirosina quinase. A mutação T315I atualmente e maior desafio para manutenção da Leucemia mieloide crônica na fase crônica, uma vez que os inibidores de Tirosina Quinase atualmente en- contrados no mercado são incapazes de mantê-la na forma controlada. Métodos computacionais baseados em fragmentos moleculares surgiram como uma nova estratégia para a descoberta de fármacos. Foi usado o programa LigBuilder para fazer geração das novas moléculas candidatas a ffármacos, usando dois métodos o Grow e Linker, as moléculas foram selecionadas por meio de docking com programa Glide da suite Maestro em cada mutação selecionadas da tirosina quinase, usando os melhores Gscores, para cada mutac¸a˜o, posteriormente foram submetidas ao programa QikProp, que tem a função comparar as moléculas com banco de dados de fármacos conhecidos. No último passo, é feito o estudo do docking das moléculas selecionas no sítio usando os protocolos de Induced Fit docking, que realiza o docking flexível-flexível, ou seja, ligante flexível e sítio de ligação da proteína flexível. / Chronic myeloid leukemia is associated with hematopoietic stem cell disorder that manifests itself primarily with myelopoiesis the expansion. The Philadelphia chromosome positive PH is generated by a reciprocal translocation (9, 22) (q34, q11), and by the merger of the Abelson gene fusion that encodes and deregulates quinase Tyrosine protein enough for the initiation and maintenance of disease. Tyrosine quinase provides a therapeutic target, which used to inhi- bition of this protein Known as tyrosine Quinase. Inhibitors such as Imatinibe mesylate has revolutionized the treatment of patients with chronic myeloid leukemia. Mutations in domain quinase Bcr-Abl, constituting the most frequent mechanism acquired resistance to therapy with tyrosine quinase. The T315I mutation and currently biggest challenge for maintenance of chro- nic myeloid leukemia in chronic phase, since inhibitors of tyrosine Quinase currently found on the market are unable to it maintaining it in a controlled manner, leading the patient achieved. Methods based on fragment docking emerged as a new strategy for drug discovery. evaluating all possible input locations and connecting the inhibitor and protein, and thus may provide a new molecule will be able to make effective inhibition. The docking studies are divided into three parts. At first, the fragments are placed to interact within the possible interaction sites. In the second step, the molecules are created from the best fragments which interacted with a particular website. In the last step, the study of molecules created in the docking site using the protocols of Induced Fit Docking which performs flexible, flexible docking ie flexible linker protein is made flexible.

Thesis on comparison of management systems of food safety was created in the years 2015-2016 at the Institute of Post-Harvest Technologies of Horticultural of the Mendel University in Brno. The main objective was to discuss the risk factors for food safety. Furthermore, describe the current approaches to the health food industry. The paper compares the current management systems securing the health food industry as HACCP, BRC, IFS, ISO 22000, FSSC 22000, GLOBALG.A.P., TESCO STANDARD.

The theme of this work is to present quality standards in a chosen company, which is producing and selling non-alcoholic drinks. The following practical part has two tasks to solve. First, to prepare documentation of HACCP plan for implementation a new product, second to try to remove defect in comparison with BRC standard. Defects are : 1. missing specification forms for private labels 2. missing measuring form of customers satisfaction

The theoretical part of the diploma work contains key principles of food safety. It includes the chapter about RASFF system and nanotechnology in food safety. Next part is about chosen food safety systems HACCP, IFS and BRC. In the practical part there is the analysis of the food safety system in the retail chain and the proposal for the more efficient one.