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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Identification of viral and bacterial etiologic agents of the Pertussis-like syndrome in children under 5 years old hospitalized

Saiki Macedo, Stephanie Alejandra, Valverde Ezeta, Jorge 14 December 2018 (has links)
Objective: To study the presence of 8 respiratory viruses (Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza-1, Parainfluenza-2 and Parainfluenza-3) and atypical bacteria (Mycoplasma pneumonia and Chlamydia pneumonia) in samples from Peruvian children under 5 years-old previously analyzed for Bordetella. Pertussis. Methods: A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. All samples were analyzed via Polymerase Chain Reaction (PCR) for the following etiologies: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza 1 virus, Parainfluenza 2 virus, Parainfluenza 3 virus, Mycoplasma pneumoniae and Chlamydia pneumoniae. Results: A total of 288 patients were included. The most common pathogen isolated was Adenovirus (49%), followed by Bordetella pertussis (41%) from our previous investigation; the most prevalent microorganisms were Mycoplasma pneumonia (26%) and Influenza-B (19.8%). Coinfections were reported in 58% of samples and the most common association was found between B. pertussis and Adenovirus (12.2%). Conclusions: There was a high prevalence of Adenovirus, Mycoplasma pneumoniae and other etiologies in patients with a probable diagnosis of pertussis. Despite the presence of persistent cough lasting at least two weeks and other clinical characteristics highly suspicious of pertussis, secondary etiologies should be considered in children under 5 years-old in order to give a proper treatment. / Objetivo: Estudiar la presencia de 8 virus respiratorios (Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza-1, Parainfluenza-2 y Parainfluenza-3) y bacterias atípicas (Mycoplasma pneumoniae y Chlamydia pneumonia) en muestras de niños peruanos menores de 5 años analizados previamente para Bordetella pertussis Métodos: se realizó un análisis de datos secundarios de un estudio transversal previo realizado en niños con un diagnóstico probable de Pertussis desde enero del 2010 hasta julio del 2012. Todas las muestras se analizaron mediante reacción en cadena de la polimerasa (PCR) para las siguientes etiologías: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, virus Parainfluenza 1, virus Parainfluenza 2, virus Parainfluenza 3, Mycoplasma pneumoniae y Chlamydia pneumoniae. Resultados: un total de 288 pacientes fueron incluidos en el estudio. El patógeno aislado más común fue el Adenovirus (49%), seguido de Bordetella pertussis (41%) de nuestra investigación previa; los microorganismos más prevelantes fueron Mycoplasma pnemoniae (26%) e Influenza-B (19.8%). Las coinfecciones fueron reportadas en el 58% de las muestras y la asociación más común se encontró entre B. pertussis y Adenovirus (12.2%). Conclusiones: hubo una alta prevalencia de Adenovirus, Mycoplasma pneumoniae y otras etiologías en pacientes con un diagnóstico probable de pertussis. A pesar de la presencia de tos persistente que dura por lo menos dos semanas y otras características clínicas altamente sospechosas de pertussis, se deben considerar las etiologías secundarias en niños menores de 5 años para poder administrar un tratamiento adecuado. / Tesis
2

Distribución de los agentes etiológicos virales y bacterianos en muestras de pacientes con diagnóstico clínico de infección por Influenza A H1N1 pandémico (H1N1 pdm09) del Hospital Regional Docente de Cajamarca durante el periodo 2009 – 2010 / Distribution of viral and bacterial etiological agents in patients samples with a clinical diagnosis of pandemic Influenza A H1N1 infection (H1N1 pdm09) of the Regional Teaching Hospital of Cajamarca during the 2009 – 2010 period

Valer Montoya, Catherine Urselia 09 November 2021 (has links)
Objetivo: Describir la distribución de patógenos responsables de IRA durante el período 2009-2010 en Cajamarca, Perú: en el contexto de la pandemia del virus de la Influenza AH1N1 2009. Resultados: Se encontraron 17 patógenos respiratorios (14 virus y 3 bacterias) en 124 niños, de los cuales el 50% eran hombres y el 50% mujeres, con un 55,6% (69/124) de 1 a 5 años y un 15,3% (19/124) de 6 a 11 años. Los patógenos más comunes fueron: Influenza A (20,2%, 25/124), Mycoplasma pneumoniae (14,5%, 18/124), RSV-A (12,1%, 15/124), Chlamydia pneumoniae (9,7%, 12/124). No se pudo identificar un patógeno específico en el 33,8% de los pacientes (42/124). Los signos y síntomas más comunes fueron fiebre 90,3%, tos 85,5%, rinorrea 74,2% y malestar 66,9%. El distrés respiratorio y la hospitalización fueron las complicaciones más comunes con 37,1% y 28,2% de los casos. Se informó una sola muerte de un niño diagnosticado con el virus de la influenza A. Además, se identificaron 12 casos de coinfecciones: 9 con 2 patógenos, 2 con tres patógenos y 1 con 4. Conclusión: Los patógenos respiratorios más comunes encontrados durante la pandemia de la Influenza AH1N1 2009-2010 fueron Influenza A, Mycoplasma pneumoniae, RSV-A y Chlamydia pneumoniae. La mayoría de patógenos presentan un perfil clínico similar Se detectaron varios casos de coinfecciones, con hasta 4 patógenos en un solo paciente. / Objective: To describe the distribution of pathogens responsible for ARI during the 2009-2010 period in Cajamarca, Peru: in the context of the 2009 AH1N1 influenza virus pandemic. Results: 17 respiratory pathogens (14 viruses and 3 bacteria) were found in 124 children, of which 50% were men and 50% women, with 55.6% (69/124) aged 1 to 5 years and a 15.3% (19/124) from 6 to 11 years old. The most common pathogens were Influenza A (20.2%, 25/124), Mycoplasma pneumoniae (14.5%, 18/124), RSV-A (12.1%, 15/124), Chlamydia pneumoniae (9,7%, 12/124). A specific pathogen could not be identified in 33.8% of patients (42/124). The most common signs and symptoms were fever 90.3%, cough 85.5%, rhinorrhea 74.2% and discomfort 66.9%. Respiratory distress and hospitalization were the most common complications with 37.1% and 28.2% of the cases. A single death was reported in a child diagnosed with influenza A virus. In addition, 12 cases of coinfections were identified: 9 with 2 pathogens, 2 with 3 pathogens, and 1 with 4. Conclusion: The most common respiratory pathogens encountered during the 2009-2010 AH1N1 influenza pandemic were influenza A, Mycoplasma pneumoniae, RSV-A, and Chlamydia pneumoniae. Most pathogens have a similar clinical profile. Several cases of coinfections were detected, with up to 4 pathogens in a single patient. / Tesis

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