Master´s thesis deals with the evaluation of existing structures according to ISO 13822, discusses the dangers that can in determining the reliability of existing structures occur. This standard shall consider the risks by analyzing the possible occurrence and impact of defects (Failure Mode and Effects Analysis). In a concrete example shows a process for determining the reliability and suggest the increase. On a practical example I use a universal risk analysis matrix (Universal Matrix of Risk Analysis) with, identify and quantify the significance of the various dangers associated with project implementation.

Master thesis deals with the evaluation of risks in the course of strengthening reinforced concrete column. It describes the assessment of existing structures according to ISO 13822, discusses the dangers that can occur when determining the carrying capacity of the existing structure. It also describes the different phases of strengthening steel banding, their functions and influence on the overall capacity. Also showing calculation process of strengthening reinforced concrete column, using steel banding, based on standard EN 1992-1-1 and EN 1998-3. In a concrete example of reinforcement is shown a process for determining the carrying capacity and then designed to the increase. In the two examples performs risk analysis using the universal matrix of risk analysis that identifies and quantifies the importance of various hazards associated with the calculation and implementation of the project.

<p>Print quality (PQ) is one of the most significant issues with electrophotographic printers. There are many reasons for PQ issues, such as limitations of the electrophotographic process, faulty printer components, or other failures of the print mechanism. These reasons can produce different PQ issues, like streaks, bands, gray spots, text fading, and color fading defects. It is important to analyze the nature and causes of different print defects to more efficiently repair printers and improve the electrophotographic process. </p> <p><br></p> <p>We design a general framework for print quality detection and analysis of customer content. This print quality analysis framework inputs the original digital image saved on the computer and then the scanned image. This framework includes two main modules: image pre-processing, print defects feature vector extraction, and classification. The first module, image pre-processing, includes image registration, color calibration, and region of interest (ROI) extraction. The ROI extraction part is designed to extract four different kinds of ROI from the digital master image. Because different ROIs include different print defects, for example, the symbol ROI includes the text fading defect, and the raster ROI includes the color fading defect. The second module includes different ROI print defects detection and analysis algorithms. We classify different ROI print defects using their feature vector based on their severity. This module proposed four important defects detection methods: uniform color area streak detection, symbol ROI color text fading detection, raster ROI color fading detection using a novel unsupervised clustering method, and raster ROI streak detection. We will introduce the details of these algorithms in this thesis. </p> <p><br></p> <p>We will also show two other interesting print quality projects: print margin skew detection and print velocity simulation and estimation. Print margin skew detection proposes an algorithm that uses the Hough Lines Detection algorithm to detect printing margin and skew errors based on factual scanned image verification. In the print velocity simulation and estimation project, we propose a print velocity simulation tool, design a specific print velocity test page, and design a print velocity estimation algorithm using the dynamic time warping algorithm. </p>

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Die ALS ist eine fortschreitende neurodegenerative Erkrankung, deren Symptome durch den Untergang der Motoneuronen bedingt sind. Neueste zytogenetische Untersuchungen zeigen ein vermehrtes Auftreten konstitutioneller Chromosomenveränderunge bei ALS-Patienten. Dies lässt eine Verbindung zwischen dem Ausbruch der Erkrankung und der auffälligen Zytogenetik vermuten. Das Auftreten spontaner Chromosomenveränderungen als Zeichen einer chromosomalen Instabilität wurde in der vorliegenden Arbeit an ALS-Patienten untersucht. METHODE: Neben der Karyotypisierung, der Bestimmung der SCE-Rate und der Bruchrate nach Behandlung mit Bleomycin kam die Fluoreszenz in situ Hybridisierung zum Einsatz. Die Untersuchungen wurden an Patienten mit sporadischer ALS (45), an Kontrollpersonen (38) und Verwandten (9) durchgeführt. ERGEBNISSE: Die Karyotypisierung ergab bei den Patienten eine spontane Translokationsrate von 0,02 Translokationen/Zelle (t/Z), bei den Kontrollen 0,04 t/Z. Weitere numerische oder strukturelle Auffälligkeiten waren nicht signifikant verschieden. Es wurden keine konstitutionellen Chromosomenaberrationen gefunden. Die Häufigkeit der Schwesterchromatidaustausche (SCE-Rate) bewegte sich mit 7-8 SCE/Z in der Patientengruppe innerhalb der Normwerte. Durch die Zugabe von Bleomycin in die Zellkultur stieg die Zahl der Chromatidbrüche von 0,0 auf 0,8 Brüche/Z an. Dabei zeigten die untersuchten Gruppen ähnliche Progredienzen in den Bruchraten. Mit der Fluoreszenz in situ Hybridisierung werden quantitative Aussagen über spontane Translokationsraten gemacht. Sie betrug in der Kontroll-und Patientengruppe 0,03 bis 0,04 t/Z. DISKUSSION: Die vorliegenden Ergebnisse liefern keinen Anhalt für eine chromosomale Instabilität als Risikofaktor für die Entstehung der sporadischen ALS. Indizien für eine chromosomale Instabilität wie erhöhte Bruchraten und SCEs als auch vermehrtes Auftreten somatischer Aberrationen konnten bei den ALS-Patienten nicht nachgewiesen werden. Über mögliche Auffälligkeiten in den Motoneuronen lässt sich allerdings mit den Untersuchungen an Blutlymphozyten keine hinreichend sichere Aussage machen. / Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which is characterized by the degeneration of motor neurons. Recently, a high rate of constitutional structural chromosomal rearrangements has been reported in apparently sporadic ALS patients. It remains questionable whether or not these genomic rearrangements are caused by a chromosomal instability involved in the pathogenesis of the disease. Therefore, we performed different cytogenetic studies on chromosomal instability. METHOD: We performed chromosome analyses from patients (N=45), control subjects (N=38), and relatives (N=9) after culturing blood lymphocytes. Conventional chromosome analysis after GTG-banding, chromosomal breakage test after Bleomycin treatment, the rate of sister chromatid exchange (SCE), and whole chromosome painting were used for these analyses. RESULTS: Neither karyotyping nor whole chromosome painting revealed higher levels of structural or numerical aberrations in lymphocytes of patients with sALS. After karyotyping we found 0.02 t/cell in patients and 0.04 t/cell in controls. Whole chromosome painting revealed 0.04 t/cell in patients and 0.03 t/cell in controls. The chromosomal breaks increased likewise after Bleomycin treatment in the control group and the patient group as well. Cell cultures without Bleomycin did not show any breaks while the highest Bleomycin concentration induced up to 0.08 breaks/cell. The SCE rate in patients which corresponds to the chromatid repair activity did not rise to a higher level than in the control individuals. Both groups were in the normal range of 7 to 8 SCE/cell. DISCUSSION: The pathomechanism of neurodegeneration in ALS patients is still unknown. We tried to find a cytogenetic correlative being a risk factor for the development of ALS. However, so far there is no clue for chromosomal instability being involved in the neurodegenerative process.