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Quantification of length-bias in screening trials with covariate-dependent test sensitivity /Heltshe, Sonya Lenore. January 2007 (has links)
Thesis (Ph.D. in Biostatistics, Department of Preventive Medicine and Biometrics) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 89-93). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Assistência pré-natal em Vitória - Espírito Santo: avaliação da concordância e da adequação do processoPolgliane, Rúbia Bastos Soares 10 April 2013 (has links)
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Previous issue date: 2013-04-10 / Introduction: Process evaluation of prenatal care is relevant in order to contribute to the actions of reducing rates of maternal and infant mortality. Objectives: To assess the agreement between the data recorded on the pregnant/´s card and the medical records of Primary Care on prenatal care in the National Health Sistem city of Vitória, Espírito Santo (ES), Brazil, to evaluate the adequacy of prenatal care in the county according to the criteria established by the Program for the Humanization of Prenatal and Birth (PHPN) and the World Health Organization (WHO) through the data recorded on the pregnant/´s cards. Methodology: Were interviewed 360 puerperae in three main public hospitals of the city of Vitória-ES, at delivery, from April 2010 to February 2011. Besides the interview, was made a full copy of the pregnant/´s card and the medical records. The information on prenatal care, their women, registered in the records of primary care were collected from January to June 2012. The data were processed and analyzed using SPSS version 18.0, PEPI version 4.0 and Microsoft Excel 2010. Statistical tests of Kappa, Kappa adjusted for prevalence and McNemar were applied to the verification of the consistency and trend of disagreement. Moreover, calculations of absolute and relative frequencies and confidence intervals were performed to analyze the adequacy of the process parameters of prenatal care. Results: The concordance between the records of pregnant/´s cards and medical records of primary care is mostly bad (Kappa<0,20). No puerpera had a process of prenatal care entirely appropriate to WHO criteria, while only 5% of the puerperae had prenatal care in consonance to PHPN. Conclusion: It is recommended that in studies evaluating or monitoring the pregnant card must be used as primary source. The adequacy of the process of prenatal care in the city far from that recommended by national and international criteria. Accordingly, strategies should be adopted to ensure the achievement of the minimum recommended procedures and to establish a pattern of systematic recording of information in the medical records of primary care / Introdução: A avaliação do processo da assistência pré-natal assume relevância no sentido de contribuir para com as ações de redução das taxas de morbimortalidade materna e infantil. Objetivos: Verificar a concordância entre os dados registrados no cartão da gestante e no prontuário da Atenção Básica sobre a assistência pré-natal no Sistema Único de Saúde (SUS) do município de Vitória, Espírito Santo (ES), Brasil; avaliar a adequação da assistência pré-natal no município segundo os critérios estabelecidos pelo Programa de Humanização do Pré-Natal e Nascimento (PHPN) e pela Organização Mundial de Saúde (OMS) por meio dos dados registrados nos cartões das gestantes. Metodologia: Entrevistou-se 360 puérperas nas três principais maternidades públicas do município de Vitória-ES, por ocasião do parto, no período de abril de 2010 a fevereiro de 2011. Além da entrevista, realizou-se cópia integral do cartão da gestante e do prontuário médico. As informações sobre a assistência pré-natal, das respectivas mulheres, registradas nos prontuários da atenção básica foram coletadas no período de janeiro a junho de 2012. Os dados foram processados e analisados nos programas SPSS versão 18.0, PEPI versão 4.0 e Microsoft Office Excel 2010. Testes estatísticos de Kappa, Kappa ajustado pela prevalência e McNemar foram aplicados para a verificação da concordância e da tendência de discordância. Além disso, cálculos das frequências absoluta e relativa e intervalos de confiança foram executados para analisar os parâmetros de adequação do processo da assistência pré-natal. Resultados: A concordância entre os registros dos cartões das gestantes e prontuários da atenção básica é, em sua maioria, ruim (Kappa<0,20). Nenhuma puérpera teve um processo de assistência pré-natal totalmente adequado segundo os critérios da OMS, enquanto apenas 5% das puérperas realizaram o pré-natal em consonância ao PHPN. Conclusão: Recomenda-se que em estudos de avaliação ou monitoramento o cartão da gestante deve ser utilizado como fonte prioritária. A adequação do processo da assistência pré-natal no município está distante do preconizado pelos critérios nacionais e internacionais. Nesse sentido, estratégias devem ser adotadas para garantir a realização dos procedimentos mínimos preconizados e para estabelecer um padrão sistematizado de registro das informações nos prontuários da atenção básica
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Evidence of methodological bias in hospital standardised mortality ratios: retrospective database study of English hospitalsMohammed, Mohammed A., Deeks, J.J., Girling, A.J., Rudge, G.M., Carmalt, M., Stevens, A.J., Lilford, R.J. January 2009 (has links)
To assess the validity of case mix adjustment methods used to derive standardised mortality ratios for hospitals, by examining the consistency of relations between risk factors and mortality across hospitals. DESIGN: Retrospective analysis of routinely collected hospital data comparing observed deaths with deaths predicted by the Dr Foster Unit case mix method. SETTING: Four acute National Health Service hospitals in the West Midlands (England) with case mix adjusted standardised mortality ratios ranging from 88 to 140. PARTICIPANTS: 96 948 (April 2005 to March 2006), 126 695 (April 2006 to March 2007), and 62 639 (April to October 2007) admissions to the four hospitals. MAIN OUTCOME MEASURES: Presence of large interaction effects between case mix variable and hospital in a logistic regression model indicating non-constant risk relations, and plausible mechanisms that could give rise to these effects. RESULTS: Large significant (P<or=0.0001) interaction effects were seen with several case mix adjustment variables. For two of these variables-the Charlson (comorbidity) index and emergency admission-interaction effects could be explained credibly by differences in clinical coding and admission practices across hospitals. CONCLUSIONS: The Dr Foster Unit hospital standardised mortality ratio is derived from an internationally adopted/adapted method, which uses at least two variables (the Charlson comorbidity index and emergency admission) that are unsafe for case mix adjustment because their inclusion may actually increase the very bias that case mix adjustment is intended to reduce. Claims that variations in hospital standardised mortality ratios from Dr Foster Unit reflect differences in quality of care are less than credible.
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Birth weight and acute childhood leukemia : a meta-analysis of observational studies /Taylor, Jean. January 2005 (has links) (PDF)
Thesis (Ph. D.)--Uniformed Services University of the Health Sciences, 2005. / Typescript (photocopy).
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