Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 4 uppsatser.

Thesis (Ph. D.)--Eberhard-Karls-Universität, 1934.

Thesis (Ph. D.)--Eberhard-Karls-Universität, 1934.

Thesis (M.S.)--University of Michigan, 1964. / Typescript (photocopy). Includes bibliographical references (leaves 33-36). Also issued in print.

Thesis (M.S.)--University of Michigan, 1964. / Typescript (photocopy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 33-36).

Thesis (M.S.)--University of Michigan, 1998. / Includes bibliographical references.

Thesis (M.D.Sc.)--University of Tennessee Health Science Center, 2005.

La bicuspidie aortique représente la malformation cardiaque congénitale la plus fréquente, affectant environ 2% de la population. Paradoxalement, le mécanisme de dégénérescence accélérée d’une valve bicuspide n’est pas encore élucidé. Ce travail s’appuie sur l’analyse de modèles animaux et sur l’analyse d’une cohorte prospective de 300 patients porteurs d’une valve aortique bicuspide.Notre cohorte de 300 patients nous a permis de chercher à identifier de nouveaux gènes impliqués dans la bicuspidie aortique par des approches de séquençage nouvelle génération, mais aussi par une approche de gène candidat. La comparaison des données cliniques et échographiques des patients porteurs de bicuspidie aortique avec et sans dysfonctionnement nous a permis d’établir une corrélation entre le phénotype de la bicuspidie et fonction valvulaire.Ce travail a eu pour objectif d’améliorer la compréhension de la physiopathologie de la bicuspidie aortique en identifiant de nouveaux gènes candidats et d’acquérir une meilleure connaissance du processus de dégénérescence valvulaire accélérée par le biais de modèles murins et d’études cliniques. / Bicuspid Aortic Valve (BAV) is the most common congenital heart defect, affecting about 2% of the population. BAV is a heritable trait, but the genetic basis underlying this defect remains unclear. BAV is associated with an excess of morbidity and mortality related to several complications such as accelerated valve degeneration that required earlier and more frequent referral for surgery. Despite its burden, the mechanism underlying BAV degeneration has not been elucidated. Aortic valve replacement constitutes a late response to a disease whose diagnosis is often carried out earlier, at the stage of non-severity. My thesis aims to identify the pathophysiology of BAV and to investigate the mechanisms involved in BAV degeneration. Thus, this study was based on the analysis of animal models and on the examination of a prospective cohort of 300 patients with BAV. Three hundred patients with BAV were prospectively included in our cohort to identify new genes involved in BAV by next generation sequencing and candidate-gene approach. The objective of this thesis was to improve our understanding of the pathophysiology of BAV and to assess the mechanisms underlying BAV degeneration by analyzing animal and clinical models.

Purpose: The aim of this study was to establish clinically relevant guidelines for the selection of clasps for removable partial dentures (RPDs) by adapting RPD clasp arms of differing materials and diameter to a three-dimensional model based on the average curvature of premolars and molars. Method: Randomly selected discarded casts were collected that had intact first premolars and first molars. The normal clasp position for the buccal surfaces of these teeth was drawn on the cast and the teeth were then sectioned to this line, and scanned using a flatbed scanner. The average curvature and length for each group was determined using a graphics-drawing programme and a 3D model was printed using these data. Clasp materials were then be adapted to these models using the wrought wires: Leowire (Leone, Fiorentino, Italy) (stainless steel); Remanium Hard (Dentaurum, Pforzheim, Germany) (stellite alloy of chromium and cobalt); Noninium (Dentaurum, Pforzheim, Germany) (stainless steel, nickel free); and cast clasps cast in the stellite alloy Vitallium (Dentsply, Ontario, Canada). Two diameters of the wrought wire clasp groups were used (0.9mm and 1.0mm). Ten samples for each diameter and material were adapted to the 3D models as they would in a clinical case. Each clasp was then randomly deformed beyond its proportional limit in a tensile testing machine (Instron Corporation, High Wycombe, United Kingdom) and the forces exerted at that limit and at deflections of 0.25 mm, 0.5 mm, and 0.75 mm were measured, as these are the clinically encountered undercuts. Statistical analysis was carried out to determine if the forces exerted at these deflections were within the proportional limit of the clasp, but also significantly within the realistic limit (defined as two standard deviations from the proportional limit) to allow for variations in manufacture and application of the clasp arms. Results: The results confirmed the effect of material, length, and diameter on flexibility for the wrought wires. A table was produced with guidelines for those clasps which could be used safely within their realistic limits and therefore should provide longevity of service. The greatest force exerted on premolar clasp length arms was provided by Leowire at 0.25mm undercut (606g); although it was 2% greater than its realistic limit, this was considered sufficiently within the safety factor to iii recommend its clinical use. The greatest force exerted on molar clasp length arms was provided by Remanium Hard at a deflection of 0.5 mm (417g). Cast clasps for premolars should not be prescribed as they were all well above their realistic limits. Cast clasps should only be selected for molars if the clasp arm is longer than 14.5mm. At a deflection of 0.25 mm the cast arm exerted a force of 773g but whilst this was below its proportional limit, it was higher than its realistic limit. Conclusions: The results of this study provide valid guidelines for the clinical application of clasp arms in removable partial dentures. It is recommended that clinical studies be carried out to confirm the longevity of clasp arms based on these data. / MT2016

Indiana University-Purdue University Indianapolis (IUPUI) / Orthodontics has been suggested as a form of treatment for temporomandibular (TM) disorders, while at the same time orthodontic treatment accompanied by premolar extraction has been blamed for producing iatrogenic internal derangement of the TM joint. Signs and symptoms of TM disorders were evaluated by a clinical history questionnaire and a thorough clinical examination. The clinical examination entailed TMJ manipulation, palpation of muscles and TM joints, and recording the active range of motion. The 45 patients in each pre-treatment and post-treatment group were obtained from the Orthodontic Clinic at the Indiana University School of Dentistry. With the exception of age, there was no statistically significant difference between the two groups.