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The clinical utility of FABP in acute coronary syndromesSmith, Nicholas James January 2001 (has links)
No description available.
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Binding studies using membrane electrodesDaly, Colette Lynn January 1989 (has links)
The research embodied within this thesis has contributed to the development and application of a novel electrode technique. The electrodes fabricated herein consist of a thin PVC/Poly (vinylchloride) membrane which is made sensitive to a particular organic cation, for example Acridine Orange. The only requirements necessary to make an electrode were that the substance to be incorporated into the membrane be cationic, water soluble and surface active. These membrane electrodes gave an emf directly proportional to the log of the ( concentration of organic cations present in solution.
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Studies on a component of the herpes simplex virus DNA polymeraseVaughan, P. J. January 1986 (has links)
No description available.
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Pharmacological characterisation of the human 5-HTâ†1â†A receptor and its inhibitory G protein fusionsWelsby, Philip J. January 2001 (has links)
No description available.
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Biochemical and x-ray crystallographic studies of monocot lectins in their native and ligated statesWright, Lisa Michelle January 1998 (has links)
No description available.
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The effect of ligands on the assembly of tubulin polymersHodgkinson, Julie L. January 1990 (has links)
No description available.
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Computer simulation of a conformational change in lactoferrinLee, David Andrew January 1999 (has links)
No description available.
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Production and analysis of escherichia coli groE chaperoninsDay, Matthew January 1996 (has links)
No description available.
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Structural and functional studies on C4b binding protein of the human complement systemChung, L. P. January 1985 (has links)
No description available.
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Histone hairpin binding protein, an RNA binding protein, essential for developmentCrombie, Catriona Ann January 2003 (has links)
Histones are proteins found in the nuclei of eukaryotic cells where they are complexed to DNA in chromatin. Rephcation-dependent histones are expressed only during S-phase. Regulation of expression of replication-dependent histone genes requires a highly conserved hairpin RNA element in the 3' untranslated region of histone mRNAs. Replication-dependent histone mRNAs are not polyadenylated; their 3' end is formed by an endonucleolytic cleavage event, 3' of a hairpin element, which is recognised by the Hairpin Binding Protein, HBP (also known as Stem-Loop Binding Protein, SLBP). This protein-RNA interaction is important for the endonucleolytic cleavage that generates the mature mRNA 3' end. The 3' hairpin, and presumably HBP, are also required for nucleocytoplasmic transport, translation and stability of histone mRNAs. It is therefore important to understand this interaction. The hairpin is highly conserved and I have demonstrated that residues in the hairpin loop are important for binding the HBP. This complimented structural studies that showed that the same residues are involved in stacking interactions in the RNA loop. In cell culture, expression of replication-dependent histone genes is S phase specific as is the expresion of HBP. Here I demonstrated that in Caenorhabditis elegans the HBP promoter is active in dividing cells during embryonic and postembryonic development. Depletion of HBP by RNAi leads to an embryonic lethal phenotype associated with defects in chromosome condensation. Postembryonic depletion of HBP results in defects in cell fate during late larval development, specifically in vulval development. A similar phenotype was obtained when histone H3 and H2A were depleted by RNAi suggesting that the phenotype of the hbp (RNAi) worms was due to a lack of histone proteins. I have confirmed this by showing that histone proteins are indeed reduced in hbp (RNAi) worms. I have also shown that depletion of HBP leads to a change in expression of a number of other proteins and specifically an up-regulation of a histone H3 like protein with an apparent molecular mass of 34 kDa. I have evidence that suggests that this protein is the centromer specific protein, CENP-A. As this protein was up-regulated when RNAi was used to deplete histones proteins, this suggests that there could be a compensatory mechanism that helps the animal to deal with the shortage of histone proteins.
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