Global ETD Search

311	The cytochrome bâ‚… fold : equilibrium and kinetic studies of folding and unfolding reactions in wild type, apo and variant proteins Manyusa, Susan January 1999 (has links) No description available. 572
312	The interaction of Ras with Raf and other potential effectors Gorman, Christine January 2000 (has links) No description available. 572
313	The properties of [H42E]HRP-C, a horseradish peroxidase variant in which histidine 42, a proton acceptor, is replaced by a glutamate Jennings, Simon Peter January 1998 (has links) No description available. 572
314	Structure/function of presenilin 1 in relation to Alzheimer's disease Smith, Stephanie Kathryn Fiona January 1999 (has links) No description available. 572
315	Neurochemical investigation of metabotropic glutamate receptors in the rat cortex using novel phenylyglycine derivatives Bedingfield, Jennifer Sarah January 1996 (has links) No description available. 615.1
316	Characterisation and comparative autoradiography of #alpha#â†2-adrenoceptors and Iâ†2-sites in mammalian brain Hudson, Alan Leslie January 1994 (has links) No description available. 615.1
317	The ex-vivo expansion of human CD8'+ cytotoxic T lymphocytes to herpes simplex virus Garland, Russell John January 2000 (has links) No description available. 570 Peptides; HLA-binding; Proteins; Markers
318	The effect of a novel series of imidazoline compounds on glucose homeostasis in the mouse Slough, Scott January 2000 (has links) No description available. 615.1
319	Towards a receptor for cytokinins Thomson, Jamie Charles Peter January 1994 (has links) No description available. 580
320	ESTROGEN BINDING SITES IN HUMAN NEOPLASIA; DETECTION USING A MORPHOLOGIC TECHNIQUE. PENNY, ROBERT JAMES. January 1984 (has links) Thirty six cases of human endometrium (9 normals, 9 adenomatous hyperplasias and 18 cancers) were established as finite monolayer tissue cultures. All were evaluated for the presence of estrogen binding sites (EBS) by an indirect immunofluorescent (IF) technique. Positive EBS were identified in 33% of normals, 67% of hyperplasias and 62% of cancers. Serial subpassage EBS evaluation was performed in fourteen cases. In was observed that the stability of EBS positivity in vitro was related to type of endometrium rather than culture longevity (2 of 2 normals, 2 of 4 hyperplasias and 1 of 8 cancers remained positive throughout the period of study). Twelve of the cancers were studied for estrogen receptor by cytosol assay and 11 (91.6%) correlated with the IF marker method. Thirty-eight cases of breast cancer were studied for EBS by a direct cytochemical and immunofluorescent technique. Evaluation by the direct method proved to be consistent and easy in performance. Morphologic positivity was 60% with the indirect method and 94.7% with the direct method. Correlation with the chemical cytosol was 77% with the indirect method and 86.8% with the direct method. These results confirm and compare favorably with other reported studies of morphologic methods. It was suggested that attention should be directed to cellular localization of receptors as a possible means for predicting endocrine responsiveness of neoplasms. Cancers from tissues presumed to be target-variants for estrogen stimulation were investigated with the direct cytochemical technique to determine if EBS were present. Forty-eight randomly selected tumors from multiple organ systems were assessed for EBS. Appropriate control tests were used to determine specificity. A total of 23 of the 48 cases were interpreted as positive for EBS. These sites were localized to cytoplasmic, nuclear and nucleolar cellular compartments. Estrogen and progesterone receptors in patients with breast carcinoma are of value in the selection of patients for hormonal adjuvant therapy. Whether this will prove to be true for EBS in a variety of neoplasms is currently unknown and is worthy of investigation. Binding sites (Biochemistry) Estrogen -- Receptors. Tumors -- Treatment.

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