Work is an essential activity that provides goods or services of value to oneself and others. Paradoxically, in a bid for self-realisation, workers are seriously endangered. Work-related or induced diseases and stresses pose serious threats to workers’ health and the general well-being, hence, the need to seriously consider the issue of occupational health and safety of workers. In terms of safety at work, the experience of small and medium scale enterprises (SMSEs) worldwide is that of neglect. Their incomes are very low and uncertain, coupled with high levels of risk and hazard in their work, with little or no social protection coverage (Chen, 2008). This study therefore examines how environmental and sociological factors determine occupational health and safety of workers in SMSEs in Lagos State, Nigeria. Ulrich Beck “Risk Society” theory, Political Economy of Health framework (PEH) (Minkler et al 1994, Linnan et al, 2001) and Labour Process Theory (LPT) (Braverman, 1974; Marx, 1976; Bottome, 1991) underpinned the study. The study adopts both the qualitative and quantitative methods of data collection. The qualitative method includes field observation of the selected workplaces, six Focus Group Discussion (FGD) and eight In-depth interviews (IDIs). The quantitative involved the use of structured questionnaire. The sample survey involved 180 respondents in a multi-stage sampling technique from purposively selected sawmills, mechanic villages and blacksmith cottages in three Local Government Areas in Lagos State. The quantitative data analysis uses simple percentile and univariate analyses, while the qualitative data are content-analysed, based on the objectives of the study. The findings identified low level of education (60.5%), and poor awareness of OHS in SMSEs (86.1%). It further reveals poor physical (69.5%) and technological environment (70.5%), unavailability of OHS facilities (60.5%) and prevention methods by manager/owners (60.5%), carefree attitudes of workers/managers/owners to OHS (69.5), non-acquaintance of workers to OHS laws (86.1%), workers’ economic incapacitation to deal with issues of occupational hazard (76.1%), lack of enforcement of OHS (88.3%), and transferring knowledge on OHS (82.2%) in the selected SMSEs. The study recommends roles for managers/owners, workers, trade associations, government, non-governmental organisations to promote effective OHS in the selected SMSEs. / Sociology / D.Phil. (Sociology)