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Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 6 uppsatser.

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 178-204).

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Bladder cancer is one of the commoner malignancies in humans and current treatments for invasive disease typically give a five year survival rate of around fifty percent. Current chemotherapeutic agents increase survival by a small amount; clearly there is the need for improved treatments and for this, novel targets need to be identified. One putative target is the Fos family member Fos-related antigen-1 (Fra-1), which form part of the AP-1 transcription factor complex. Fra-1 is elevated in numerous human malignancies and regulates the transcription of genes involved in many aspects of the malignant process, such as migration and invasion. Regulatory control of Fra-1 has been incompletely studied to date; it is known that MAP Kinase dependent signalling can influence Fra-1 accumulation but other aspects of control are only now being elucidated. This thesis demonstrates that Fra-1 is present in the majority of bladder cancers, that it is regulated by the structure of the C-terminus and MAP Kinase dependent phosphorylation of the amino acids Ser[superscript 252] and Ser[superscript 265], and undergoes proteasomal degradation. This highlights the potential role of Fra-1 as a novel therapeutic target and provides more information on the regulation of Fra-1 which may be targeted with novel agents.

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Bibliography : leaves 166-187. / 187 leaves : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Looks at the laboratory development and clinical use of new techniques for bladder augmentation, all of which result in a neo-bladder lined by urothelium. The combination of autoaugmentation and demucosalised enterocystoplasty was explored in a sheep model. / Thesis (M.D.)--University of Adelaide, Dept. of Surgery, 1995?

Of the common adult lanternfishes found off Oregon, two species have fat-invested swimbladders (Stenobrachius leucopsarus Eigenmann and Eigenmann 1890 and Stenobrachius nannochir Gilbert 1891), two species have reduced swimbladders (Lampanyctus ritteri Gilbert 1915 and Lampanyctus galis Gilbert 1891), two species have gas-filled swimbladders ((Protomyctophum thomp soni (Chapman 1944)) and (Protomyctophum crockeri (Bolin 1939)). Adult Diaphus theta Eigenrnann and Eigenmann 1891 and adult Tarletonbeania crenularis Jordan and Gilbert 1880 however, have either gas-filled or reduced swimbladders. Small individuals of all the above species have gas-filled swimbladders. The primary buoyancy mechanism is lipids for large S. leucopsarus, S. nannochir, L. ritteri andD. theta, is reduction of dense material for large L. regalis, and is gas for all juveniles and for P. thompsoni, P. crockeri and some adult T. crenularis and D. theta. / Graduation date: 1971

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