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Orientador: Frederico Andrade e Silva / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-13T01:24:11Z (GMT). No. of bitstreams: 1 Cvijic_Gojko_M.pdf: 808997 bytes, checksum: 9dea6418612a9a36ca0683f628728557 (MD5) Previous issue date: 2009 / Resumo: Varias pesquisas tem mostrado que aumento de energia na superfície e a fabricação do implante na ausência de ar, aumenta a hidrofilia da superfície reduzindo o tempo da osseointegração. O objetivo desse estudo foi a avaliar o tempo de vida útil e o Nível de Reabsorção Óssea (NRO) entre os implantes com superfícies química (SLActive) e fisicamente (SLA) tratadas, instalados em maxilas previamente enxertadas com osso autógeno em bloco, e carregados com coroas unitárias parafusadas. Foram utilizados 17 voluntários e 20 implantes (10 com superfície SLA e 10 com superfície SLActive). Dez semanas após a instalação dos implantes no grupo controle (SLA) e 4 semanas no grupo teste (SLActive), foram iniciados os procedimentos para a confecção das próteses parafusadas. Os pilares foram apertados com força de 35Ncm, 12 semanas após a colocação dos implantes com superfície SLA e após 6 semanas com a superfície SLActive. As radiografias periapicais foram tomadas e avaliadas no ato da colocação dos implantes, no dia de aperto do pilar, e, 1 e 3 meses com a coroa definitiva em função. Foi realizada a comparação do NRO entre dois tipos de superfícies. Dois implantes SLActive foram perdidos durante o aperto dos pilares. Os resultados mostraram que NRO ao redor dos implantes com 3 meses em função foi menor no grupo teste quando comparado com grupo controle. Os implantes com superfície SLActive instalados na maxila, na área tratada com enxerto ósseo em bloco, e carregados com coroas unitárias 6 semanas após a instalação, tiveram menor vida útil quando comparados com implantes com superfície SLA. / Abstract: Many researches have shown that higher energy of dental implants and production in chamber without air, enlarge surface hidrofilicity and reduce osseointegration time. The aim of this study was to evaluate the survival rate and the Level of Bone Resorption (LBR) between the implants with chemically and physically treated surfaces, placed in maxillae previously treated with bone block grafts, and loaded with single screwed crowns. Seventeen patients were treated with 20 implants (10 with SLA and 10 with SLActive surface). Ten weeks after implant placement in control group (SLA) and four weeks in test group (SLActive) we began with prosthodontical treatment. The abutments were tightened with 35Ncm, 12 weeks after placement of implants with SLA surface, and after 6 weeks with SLActive surface. Periapical radiographies were made and evaluated after implant placement, after abutment tightening, 1 and 3 months with crown in function. We have done a comparison of LBR between two surfaces. The results have shown that LBR around the implants in function was smaller in the test group comparing to the control group, while implants with SLActive surfaces placed in maxillae, previously treated with bone block graft, and loaded with single screwed crowns 6 weeks after, have smaller survival rate comparing to SLA implants. / Mestrado / Protese Dental / Mestre em Clínica Odontológica

Orientadores: Marcio de Moraes, Luciana Asprino / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-13T02:18:28Z (GMT). No. of bitstreams: 1 Lyrio_MarianaCamiloNegreiros_M.pdf: 2393437 bytes, checksum: f0dfbf68baaeb080347c83445d15e1e9 (MD5) Previous issue date: 2009 / Resumo: O propósito neste estudo foi realizar avaliação mecânica e fotoelástica de dois diferentes sistemas de fixação interna rígida (FIR): placas convencionais e placas com sistema de travamento. Para avaliação mecânica foi realizado teste de carregamento linear em réplicas de hemimandíbulas humanas dentadas seccionadas na região de ramo mandibular, representando uma osteotomia sagital, e fixadas com avanço mandibular de 5 mm. No grupo I a fixação foi realizada com placas convencionais e parafusos monocorticais do sistema 2,0mm e no grupo II utilizou-se placas e parafusos monocorticais com sistema de travamento do sistema 2,0 mm. Para análise estatística foram aplicados Anova e teste de Tukey em nível de significância de 5%, os quais demonstraram não haver diferenças entre os grupos I e II nos testes mecânicos. Para os testes fotoelásticos foram confeccionadas hemimandíbulas humanas dentadas em resina fotoelástica, também seccionadas simulando a osteotomia sagital e fixadas com avanço mandibular de 5 mm, com os mesmos grupos utilizados para os testes mecânicos. Em relação à distribuição de tensões, pode-se observar que as mesmas se concentram ao redor dos parafusos, principalmente naqueles próximos à área de osteotomia para ambos os grupos. Dessa forma, pode-se afirmar que os sistemas de fixação utilizando placa e parafusos convencionais ou com sistema de travamento não apresentaram diferenças estatísticas quanto à resistência, e que a maior concentração de forças está nas áreas próximas às osteotomias, consideradas regiões de maior fragilidade após a OSRM. / Abstract: The aim of this study was evaluate the mechanical and photoelastic behavior of two methods of rigid internal fixation (RIF): conventional plates and locking plates. For mechanical tests polyurethane synthetic hemimandible with seccional sagittal ramus split was used, simulating an advancement of 5 mm. The fixation performed on the Group I was a 2.0 mm conventional plates with monocortical screws and fixation used on group II was a 2.0 locking plates with monocortical locking screws. Anova and Tukey tests were applied (P<5) and no statistical differences were noted between the groups. Hemimandibles were made in photoelastic resin with same groups used in mechanical tests and submitted to photoelastical analysis. In relation to tension distribution in photoelastic analysis, the fringes were concentrated around screws, mainly in areas near the osteotomy for both groups. Based in this fact, the conventional and locking fixations systems did not present statistical differences on resistence, and the major forces was concentrated in regions near the osteotomies lines, that considered fragility before sagittal split osteotomy. / Mestrado / Cirurgia e Traumatologia Buco-Maxilo-Faciais / Mestre em Clínica Odontológica

Orientador: Renato Mazzonetto / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-15T07:07:58Z (GMT). No. of bitstreams: 1 ChavesNetto_HenriqueDuquedeMiranda_D.pdf: 1149047 bytes, checksum: 7a66407042b1a6d612bfca74f5a991b2 (MD5) Previous issue date: 2010 / Resumo: Desde o desenvolvimento da implantodontia, associou-se estética à função nas reabilitações, aumentando a necessidade de enxertos ósseos visando a instalação adequada destes implantes. O processo de incorporação dos enxertos geralmente é acompanhado através de análise clínica e exames de imagem. Deste modo, diversos estudos vêm sendo desenvolvidos. O presente trabalho apresenta 3 pesquisas em modelo animal, descritas nos Capítulos à seguir. CAPITULO I: Comparação histológica das diferenças existentes no processo de reparo ósseo em defeitos criados em calotas cranianas de cães, preenchidos com coágulo e enxerto ósseo autógeno particulado, a fim de se estabelecer uma classificação, defeito crítico ou não crítico, dos defeitos de 8mm de diâmetro. Observou-se, em dois períodos de sacrifício, correspondentes as fases inicial e tardia do processo de reparo ósseo, que os defeitos preenchidos com coágulo sangüíneo apresentaram um processo de reparo inferior ao grupo preenchido por enxerto ósseo autógeno, sendo este o único que apresentou aposição de tecido ósseo nos dois períodos. Deste modo, pode ser concluído que os métodos que auxiliam no processo de reparo ósseo estão indicados em casos de defeitos iguais ou maiores que 8mm, sendo este classificado como crítico. CAPITULO II: O propósito deste capítulo foi estabelecer uma relação entre os exames radiográficos e o processo de incorporação de enxertos ósseos de origem autógena, heterógena (matriz óssea bovina anorgânica) e coágulo sangüíneo, em defeitos criados em calotas cranianas de cães. Observou-se nos periodos correspondentes às fases inicial e final do processo de reparo ósseo os exames de imagem. Apesar de apresentarem-se divergentes na proservação do processo de incorporação destes enxertos, obtiveram resultados semelhantes as análises histológicas somente nos grupos de coágulo sangüíneo e enxerto ósseo de origem autógena. Deste modo, os exames radiográficos servem como parâmetro na proservação de procedimentos de reconstrução somente quando são utilizados enxertos ósseos de origem autógena, assim como casos de reparação espontânea através do coágulo sangüíneo. CAPITULO III: O objetivo deste estudo foi avaliar histológica e histométricamente a interface enxerto ósseo versus leito receptor em cães.Para tanto foram obtidos dois blocos de enxerto ósseo córtico-medular de cada cão, sendo que um destes foi fixado com a interface cortical voltada para o leito receptor, enquanto o outro foi fixado com a face medular voltada ao leito receptor. Os 6 cães foram divididos em dois períodos de sacrifício. Pode-se observar presença de tecido conjuntivo, vasos sangüíneos, tecido ósseo neoformado em ambos grupos nos dois períodos de sacrifício. A analise histométrica evidenciou que a formação de tecido ósseo neoformado foi estatisticamente semelhante em ambos grupos. Deste modo, pode-se concluir que a estrutura cortical ou medular não interferiu na formação de tecido ósseo na região de interface entre enxerto e leito receptor / Abstract: Since the implantodontology was developed, aesthetics was associated to function, increasing the requirement of bone grafting meaning the correct installation of them. The bone grafting integration process generally are accompanied thru out clinical and images exams. Thus, several studies are being developed. The present work performed 3 researches using animal model, divided in Chapters. CHAPTER I: Had the meaning to compare, thru out descriptive histological analysis, the differences that exists on bone healing in defects created in dogs calvarium, fulfilling with clot and particulate autogenous bone graft , meaning the establish a classification, such as critic or non-critic, of the 8mm diameter defects created on dogs calvarium. It was observed, on both sacrifice periods, similar to earlier and late phases of the bone healing repair, that the defects fulfilled with blood clot presented an inferior healing process when compared with the autogenous bone graft group, being this the unique that showed apposition of mineralized tissue on both periods. Thus, bone defects over 8mm can be considered critical, being necessary some method to help tissue repair, as well as, autogenous bone grafts works well when helping this regeneration process, being indicated to assist bone repair like this performed on this study. CHAPTER II: The aim of this research was to establish a relation between radiographic exams and bone grafting integration of autogenous bone graft and heterogenous bone graft (anorganic bovine bone matrix) and blood clot in defects performed on dogs calvarium. It was observed that on the correspondent periods of initial and delay phases of bone healing repair the radiographic exams. Besides presented divergent on the accompaniment of heterogenous bone graft, they obtained similar results from histological analysis on blood clot and autogenous graft groups. As concluded, radiographic tests can de used as a parameter for reconstruction proservation only when autogenous bone grafts are used, as well as in cases of spontaneous repair through blood clot. CHAPTER III: The proposal of these chapter was value, thru out histological descriptive and histometric analysis,the interface between bone graft and receipt area in dogs.To perform that, it was obtained 2 cortical-medullar bone blocks from each dog, being one fixed with the cortical face in contact to the receipt area and another fixed with the medullar face in contact to the receipt area. It was observed the presence of connective tissue, blood vessel, and mineralized tissue formation on both sacrifice periods. The histometric analyze showed that the bone tissue formation in this region was found to be statistically similar and did not influence the autogenous bone graft incorporation process / Doutorado / Cirurgia e Traumatologia Buco-Maxilo-Faciais / Doutor em Clínica Odontológica

Breast cancer has a high propensity to metastasize to bone. While the genetic and epigenetic changes associated with metastatic breast cancer progression are being identified, the changes that drive metastatic progression are poorly understood. Proteases, and in particular matrix metalloproteinases (MMPs), have been shown to play a pivotal role in certain aspects of tumor metastasis by modifying the affected microenvironment. Bone matrix-depositing mouse MC3T3 osteoblasts were co-cultured with metastatic human MDA-MB-23 1 (MDA23 1) cells or the bone-homing MDA-MB 231-1 833/TR (1 833/TR) variant in an effort to identify novel, osteoclast-independent, changes to the tumor/bone microenvironment. Co-culture-induced changes in the complete “protease and inhibitor” expression profile in the osteoblasts and the tumor cells were then determined using targeted murine and human specific microarray chips (CLIP-CHIP TM ). This analysis revealed an increase in the RNA expression of collagenase-3 (MMP 13) in the co-cultured osteoblasts that was confirmed by qPCR. Further, Western blotting indicated increased MIvIP13 protein secretion into the bone matrixltumor microenvironment by the co-cultured MC3T3 cells. The elevation in osteoblast-produced MMP13 was observed when the co- cultured tumor cells were in direct contact or separated by filters. Additionally, the elevation was also induced by conditioned medium derived from separate MDA23 1 or 1 833/TR cultures, which indicates that a soluble factor produced by the tumor cells is capable of inducing MMP 13. One soluble factor that appears to be produced by 1 833iTR cultures is oncostatin M. Oncostatin M is an interleukin-6 family cytokine that is known to upregulate MMP13 synthesis and secretion during chondrogenesis. Genome-wide Affymetrix® analysis revealed, and qPCR analysis confirmed, that oncostatin M receptor-specific subunit RNA was also significantly upregulated in co-cultured osteoblasts. Therefore, breast tumor cells may be capable of initiating protein degradative changes in the bone microenvironment that are independent of the much studied osteolytic degradation initiated by osteoclast activation. / Medicine, Faculty of / Graduate

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Introduction: The process by which children's bones grow has not been fully charcterised. The current dogma is that girls fill in their medullary canal area by forming bone at the endosteum. It has been argued that the sex difference in how bone strength is conferred -- favouring boys -- may contribute to the relative protection that aging men have over aging women with respect to fracture incidence and the prevalence of osteoporosis. Primary Objectives: 1)To compare bone surface changes at the periosteal and endosteal surface of the tibial midshaft in boys and girls. 2)To compare how bone density at the tibial midshaft is accrued in boys and girls. 3) To compare sex differences in bone strength accrual. Methods: Design and Participants: Participants were obtained from a 20-month randomized, controlled school-based physical activity intervention. As we found no difference in the effect of the intervention on pQCT bone outcome variables, both groups were combined for our current study. A total of 183 participants (93 boys, 89 girls) received a pQCT scan at baseline. Results: Sex-specific comparisons of the pQCT bone outcome variables showed significantly greater rates of change (slope) for boys for the total area (ToA), cortical area (CoA), medullary canal area (MedA) and strength-strain index (SSI) measures, p<0.001. No significant differences were observed for CoD, p=0.904. The magnitude of these differences is 60.8% for ToA, 55.7% for CoA, 75.6% for MedA, 1.3% for CoD, and 54.7% for SSI. Examination of differences between the sexes (intercept) revealed significant differences with greater gains observed for boys for all measures p<0.001 except for CoD where girls exhibited greater gains p<0.001. Conclusion: Girls showed a similar pattern of cortical bone growth at the tibial midshaft- periosteal apposition dominated over endosteal resorption. Boys' increased changes and pattern of growth were of a greater magnitude at both surfaces compared to girls. This resulted in a greater increase in strength as measured by SSI in boys which can partly be explained by their larger size. Girls exhibited greater increases in CoD; however, no significant difference in the change in CoD was observed between the two. / Medicine, Faculty of / Medicine, Department of / Experimental Medicine, Division of / Graduate

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