Magister Scientiae Dentium - MSc(Dent) / The purpose of this study was to compare the accuracy of direct versus indirect bracket placement in orthodontics in a controlled setting. The more accurate the initial bracket placement is the less time will be required in terms of treatment. Accurate bracket placement can reduce the envelope of error in the three dimensions of vertical (incisal height, height of tooth), horizontal (mesial-distal) and angular (degrees incisal to root apex causing rotational irregularities) based on Andrews’ six keys to normal occlusion (Andrews, 1979). In this comparative experimental study, 10 Class I molar relation study models were selected from the researcher’s practice archives. Only the MBT pre-adjusted or angulated orthodontic brackets were used on manikins, followed by the use of 3D CAD CAM technology to evaluate the results against a pre-determined golden standard.