ABSTRACT In the context of increasing incidence of stroke (but also an increasing rate of survival), non-invasive brain stimulation techniques (NIBS) are more frequently used for patients with post-stroke aphasia (PWA) and post-stroke depression (PSD). NIBS techniques, modulating brain plasticity, might offer valid, alternative therapeutic strategies. The aim is to reach a better outcome because treatment of aphasia can also improve post-stroke depression and vice versa. Based on two literature reviews on NIBS effects on PSD and post-stroke aphasia the conclusion is that, although the field is relatively new, and many more investigations with larger samples of patients are required, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) clinical application is well tolerated, safe, and feasible. Starting from these encouraging data, we used a combination of TMS and electroencephalography (EEG) to explore the excitability modulation before and after active (20 sessions) and sham (20 sessions) tDCS in a double-blind crossover experiment. Four chronic non fluent PWA underwent 8 weeks of verbal exercises coupled with tDCS over the perilesional areas close to the left inferior frontal gyrus. To evaluate changes induced by tDCS, TMS-EEG responses over Brodmann area 6 (BA6) were computed using five different parameters. In addition, these data were compared with those recorded from a matched control group. The results indicated a slight improvement after tDCS stimulation (as compared to sham) for patients with Broca’s aphasia, but not for those with global aphasia. Also, TMS-evoked EEG responses recorded from the ipsilesional hemisphere were abnormal in individuals with chronic post-stroke aphasia (slower and simple responses with higher amplitudes) when compared to responses from the contralesional hemisphere and from the control group. Critically, the Global Mean Field Power (GMFP), Local Mean Field Power (LMFP) and Natural Frequency values were modulated by anodal tDCS. Despite these interesting results, further data are needed in order the obtain more direct, stronger evidence linking behavioral tDCS effects and neurophysiological data.

This thesis aims to examine students&rsquo / attitudes towards brain-based applications in the English Composition II course. For this purpose, a case study was carried out with a group of 23 first year students at the Department of Foreign Language Education at Middle East Technical University in the second half of the 2002-2003 academic year. After receiving writing training with a brain-based methodology for ten weeks, the students were given an attitude questionnaire which aimed at identifying their attitudes towards brain-based applications in the course. One week later, the iv researcher also conducted interviews with 10 of the 23 students separately to investigate students&rsquo / attitudes towards brain-based applications in the course further. The analysis of the data collected through the attitude questionnaire indicated that 93 % of the students showed significant positive attitudes towards the brain-based applications, while only 1 % of the students had negative attitudes towards the brain-based applications. The analysis of the results of the interviews also revealed that all students had positive feelings about the brain-based applications. Accordingly, the results indicated taking this composition course resulted in highly positive feelings such as confidence, relaxation, or being valued in the students. All students found writing meaningful and relevant to themselves. They stated to have acquired various skills during the course such as writing skills, computer skills, teaching skills, emotional intelligence, and an awareness of needs. They found these useful and meaningful for their lives in general, as students, and as teachers as part of their future profession.

Afhandling, Linköpings universitet, 2007.

Summaries in Afrikaans and English / Text in Afrikaans / Two opposing approaches to beginning reading are used, namely the phonological and global approach, under which the whole word, whole sentence and whole language methods are classed. The whole crux of the controversy is situated in beginning reading as an explicit, intensive and systematic method of teaching phonics, as opposed to implicit beginning reading through discrimination of global configurations, augmented by psycholinguistic guesses within reading context. Arguments about the advantages and disadvantages of the opposing methods have been hurdled to and fro for decades without any discernible gain. The question emerged whether research on brain physiology with respect to language and reading, a relatively new field of study, could shed light on the foundation of an accountable method for beginning reading. Renewed insights to the controversial differences were gained, and brain physiologically accountable parameters as a base for a beginning reading method were framed from these insights. / Twee opponerende aanvangsleesbenaderings word in die skole gebruik, naamlik die fonologiese benadering en die geheelbenadering, waaronder die geheelwoord-, geheelsinen die geheeltaalmetode ressorteer. Die kern van die verskil tussen die aanvangsleesbenaderings le in aanvangslees as eksplisiete, intensiewe en sistematiese foneemonderrig, teenoor implisiete aanvangslees wat die waarneming van globale konfigurasies, aangevul deur psigolinguistiese raaiskote binne die leeskonteks, aanmoedig. In die polemiek om die beste leesmetode word argumente oor die voor- en nadele ten opsigte van die begronding van hierdie opponerende metodes reeds dekades heen en weer geslinger. Navorsingsresultate word eindeloos, sonder duidelike winste, met mekaar vergelyk. Dit het die vraag laat onstaan of navorsing ten opsigte van die breinfisiologie met betrekking tot taal en lees, 'n relatief nuwe studieveld, moontlik lig sou kon werp op die begronding van 'n verantwoordbare aanvangsleesmetode. Die literatuurstudie ten opsigte van breinfisiologie het vernuwende insigte oor die polemiese begrondingsverskille na vore gebring, en breinfisiologies-verantwoordbare parameters as basis vir 'n aanvangsleesmetode is uit hierdie insigte opgestel. / Psychology of Education / M. Ed. (Psychology of Education)

Summaries in Afrikaans and English / Text in Afrikaans / Two opposing approaches to beginning reading are used, namely the phonological and global approach, under which the whole word, whole sentence and whole language methods are classed. The whole crux of the controversy is situated in beginning reading as an explicit, intensive and systematic method of teaching phonics, as opposed to implicit beginning reading through discrimination of global configurations, augmented by psycholinguistic guesses within reading context. Arguments about the advantages and disadvantages of the opposing methods have been hurdled to and fro for decades without any discernible gain. The question emerged whether research on brain physiology with respect to language and reading, a relatively new field of study, could shed light on the foundation of an accountable method for beginning reading. Renewed insights to the controversial differences were gained, and brain physiologically accountable parameters as a base for a beginning reading method were framed from these insights. / Twee opponerende aanvangsleesbenaderings word in die skole gebruik, naamlik die fonologiese benadering en die geheelbenadering, waaronder die geheelwoord-, geheelsinen die geheeltaalmetode ressorteer. Die kern van die verskil tussen die aanvangsleesbenaderings le in aanvangslees as eksplisiete, intensiewe en sistematiese foneemonderrig, teenoor implisiete aanvangslees wat die waarneming van globale konfigurasies, aangevul deur psigolinguistiese raaiskote binne die leeskonteks, aanmoedig. In die polemiek om die beste leesmetode word argumente oor die voor- en nadele ten opsigte van die begronding van hierdie opponerende metodes reeds dekades heen en weer geslinger. Navorsingsresultate word eindeloos, sonder duidelike winste, met mekaar vergelyk. Dit het die vraag laat onstaan of navorsing ten opsigte van die breinfisiologie met betrekking tot taal en lees, 'n relatief nuwe studieveld, moontlik lig sou kon werp op die begronding van 'n verantwoordbare aanvangsleesmetode. Die literatuurstudie ten opsigte van breinfisiologie het vernuwende insigte oor die polemiese begrondingsverskille na vore gebring, en breinfisiologies-verantwoordbare parameters as basis vir 'n aanvangsleesmetode is uit hierdie insigte opgestel. / Psychology of Education / M. Ed. (Psychology of Education)