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Introduction: Osteogenesis imperfecta (OI) is a condition that affects the whole family on many levels and is important to consider the management of the disease and its impact on occupational participation and engagement in daily activities. Aim: To explore the natural occupational adaptation process (OAP) and its impact on daily activities among individuals and families with OI. Method: Using Arksey and O’Malley’s five-step Scoping Study Framework (2005), a scoping review of 24 articles from seven online databases and literature hand-searching was conducted. Data extraction was performed for all studies that met the eligibility and quality criteria. Five main themes containing several subthemes were emerged in qualitative inductive thematic analysis. Findings: Findings from 24 reports highlight the social and emotional impact along with the physical challenges of living with OI that direct into adaptation process. Different occupational adaptation strategies that emerged in the data help overcome physical deficits and psychosocial implications and facilitate occupational participation and engagement in meaningful activities. Conclusions: The study confirmed these individuals’ and families’ high coping skills, despite experiencing many obstacles in their daily life. Significance: To better understand the adaptation process in OI population and give practical implications for occupational therapists to offer a better support these families need.