This dissertation provides one methodology to determine potential energy savings of buildings with limited information. This methodology is based upon the simplified energy analysis procedure of HVAC systems and the control of the comfort conditions. Numerically, the algorithm is a tailored exhaustive search over all the independent variables that are commonly controlled for a specific type of HVAC system. The potential energy savings methodology has been applied in several buildings that have been retrofitted and/or commissioned previously. Results from the determined savings for the Zachry building at Texas A&M after being commissioned show a close agreement to the calculated potential energy savings (about 85%). Differences are mainly attributed to the use of simplified models. Due to the restriction of limited information about the building characteristics and operational control, the potential energy savings method requires the determination of parameters that characterize its thermal performance. Thus, a calibrated building is needed. A general procedure has been developed to carry out automated calibration of building energy use simulations. The methodology has been tested successfully on building simulations based on the simplified energy analysis procedure. The automated calibration is the minimization of the RMSE of the energy use over daily conditions. The minimization procedure is fulfilled with a non-canonical optimization algorithm, the Simulated Annealing, which mimics the Statistical Thermodynamic performance of the annealing process. That is to say, starting at a specified temperature the algorithm searches variable-space states that are steadier, while heuristically, by the Boltzmann distribution, the local minima is avoided. The process is repeated at a new lower temperature that is determined by a specific schedule until the global minimum is found. This methodology was applied to the most common air-handler units producing excellent results for ideal cases or for samples modified with a 1% white noise.