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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Imunotypové rozdíly v subpopulacích CD27+ B lymfocytů u zdravých kontrol a pacientů s různými imunopatologiemi / Differences in immunophenotype of CD27+ B lymphocyte subpopulations in healthy controls and patients with various immunopathologies

Valatová, Pavla January 2016 (has links)
The immune system will maintain the integrity of the organism from harmful non-malicious recognizes and protects the body against exo- and endogenous toxic substances and together with the nervous and endocrine system are among regulatory systems of the organism. Recently the evidence has supported the emerging concept of different B cell subpopulations to play a direct or indirect role in a pathogenesis of spectrum of disorders. However, so far the knowledge has been limited mainly in the way of how the specific differentiation stages of B lymphocytes are involved in pathogenesis of diseases and how course of disease, stage, and eventually different treatment can affect B cell homeostasis. This work is focused on the study of peripheral CD27+ B lymphocytes (one of the least explored human B lymphocytes) in healthy controls and patients with various immunopathologies, in this case we present representative results for patients with inflammatory bowel disease. Using polychromatic flow cytometry we examined 31 of peripheral blood samples, including 14 controls, 7 patients with Crohn's disease (CD) and 5 with ulcerative colitis (UC). In 6 patients with CD, we were able to perform immunophenotyping also 2 hours after intravenous administration of infliximab, and in one patient 14 days after drug...
12

Caractérisation des variations fonctionnelles des cellules NK entre deux lignées murines

Mullins-Dansereau, Victor 08 1900 (has links)
No description available.
13

Étude de l'implication neurologique et immunologique de la voie costimulatrice CD27/CD70 dans la sclérose en plaques

Tremblay, Laurence 05 1900 (has links)
No description available.
14

Effet de l'exposition à la fumée de cigarette sur le profil oxydatif et la sénescence des différentes sous-populations lymphocytaires T CD4+ / Analysis of the response to oxydative stress by lymphocytes T conventional and treg

Baskara-Yhuellou, Indoumady 20 December 2013 (has links)
La Broncho-Pneumopathie Chronique Obstructive (BPCO) est caractérisée par une destruction du parenchyme pulmonaire, une obstruction des voies aériennes et une réponse inflammatoire anormale en réponse à un stress oxydant chronique lié au tabagisme. L’incidence accrue de la maladie chez les personnes âgées fait postuler que la sénescence cellulaire pourrait contribuer à la pathogenèse de la maladie. Une augmentation des marqueurs de stress oxydant et de sénescence est détectée dans le poumon des patients atteints de BCPO, associée à une diminution des lymphocytes T régulateurs (Treg : CD4+CD25highCD127-/low) et une augmentation d’une sous-population pro-inflammatoire Th17 (Th17 : CD45RO+CCR6+) parmi les lymphocytes T conventionnels (Tconv : CD4+CD127+) pulmonaires, alors que la fréquence des Treg est augmentée en périphérie. Différents marqueurs d’immunosénescence sont présents dans le sang périphérique des patients atteints de BPCO : raccourcissement des télomères des leucocytes, augmentation de la fréquence des lymphocytes T sénescents CD8+CD28- et CD4+CD28- ainsi que des CD4+CD57+. Cependant, le rôle causal d’une altération de la réponse au stress oxydant dans les anomalies et la sénescence des cellules immunes associées à la BPCO n’est pas établi / The Chronic obstructive pulmonary disease ( BPCO) is characterized by a destruction of the lung parenchyme, an obstruction of air traffics and an abnormal inflammatory answer in answer to an oxidizing stress chronicles smoking-related. The greater incidence of the disease at the elderly makes postulate(apply) that the cellular senescence could contribute to the pathogenesis of the disease

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