Global ETD Search

11	T cell homeostasis : a role for specific peptide/MHC ligands in homeostasis driven proliferation of naive CD8⁺ T cells / Goldrath, Ananda W. January 2000 (has links) Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 89-102).
12	Acquisition and function of NK cell-associated molecules on T cells / Assarsson, Erika, January 2003 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
13	Regulation of interleukin-2 gene transcription in CD8 positive cells / Finch, Rosalynde J. January 2000 (has links) Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 89-102).
14	Generation and expression of high affinity, tumor antigen-specific mouse and human T cell receptors to genetically modify CD8⁺ T cells for adoptive immunotherapy of cancer / Dossett, Michelle Leigh. January 2006 (has links) Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 122-135).
15	Chronic Inflammation-Driven Tumor Promotion Asociated with CD8+ T Cells Ng, Bernice Yu Jing 09 April 2008 (has links) Chronic inflammation is associated with carcinoma development in several clinical settings, and we sought to investigate the role of T cells in this phenomenon using the DMBA/TPA two-stage chemical carcinogenesis protocol. We demonstrate that, paradoxical to models of immunosurveillance, wild-type (WT) mice have a markedly higher rate of tumor formation relative to strains lacking CD8+ T cells. Adoptive transfers of antibody-coated magnetic bead-enriched peripheral CD8+ T cells into TCRáâ-/- mice confirmed that the increased mean tumor area and progression to carcinoma was attributable to the presence of CD8+ T cells. All analyzed strains of mice in which the CD8 compartment was intact (WT, CD4-/-) showed significant increases in tumor susceptibility. Putative tumor-promoting (T-pro) cells (TCRáâ+CD8+CD44+CD62L- tumor infiltrating lymphocytes, TILs) were directly compared to their phenotypic equivalents in peripheral blood lymphocytes (PBLs). In WT and CD4-deficient mice, CD8+ TILs consistently revealed a markedly higher relative expression, by RT-PCR, of IFNã, TNFá and COX-2, and a striking decrease in expression of perforin. Cytokine-bead analysis (CBA) comparison of CD8+ and CD4+ TIL in tumors from WT mice confirmed the increased expression by the CD8+ TIL of IFNã and TNFá. To our knowledge, this is the first demonstration of increased carcinogenesis attributable to CD8+ TILs, characterized by their high IFNã, TNFá, and COX-2 production and defective perforin production relative to phenotypically equivalent PBLs. These studies may have mechanistic implications for the role of T cells in inflammation-associated carcinogenesis. oncology dermatology CD8-positive T-lymphocytes T-lymphocyte subsets lymphocytes tumor-infiltrating mice skin neoplasms
16	On the immunopathogenesis of HIV infection Jakob Nilsson. Nilsson, Jakob, January 2006 (has links) Disputats, Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser. Med populärvetenskaplig sammanfattning på svenska.
17	Visualizing the function and migration of T cells Dugger, Kari J. January 2007 (has links) (PDF) Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb. 6, 2008). Includes bibliographical references.
18	Immune dysregulation in HIV-1 infected lymphoid tissue / Behbahani, Homira, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 6 uppsatser.
19	Immunoregulation of experimental autoimmune neuritis focuses on cell immunity / Zhu, Yu, January 2003 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
20	Characterisation of CD8 T cells in mucosa associated lymphoid tissue: implications for immune control of HIV-1 infection / Quigley, Máire, January 2006 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.

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