Cardiopulmonary resuscitation (CPR) manikins are an educational technology tool employed to train nurses to perform high-quality CPR during real-life cardiac arrest events. However, a gap exists between CPR skills learned in training and those used in real life. The purpose of this quantitative study was to examine how CPR feedback and anxiety in registered nurses affect CPR performance on a manikin. Distributed practice and attentional control theory served as the foundations for this study. The research questions addressed the influence of demographic factors, real-time CPR feedback, and simulated hospital noises on CPR performance using CPR manikins. The study included a randomized longitudinal experimental design. Data were collected from 120 nurses via a demographic questionnaire, the Cognitive and Somatic Anxiety Questionnaire, and CPR compression performance feedback via a Zoll R Series defibrillator. Data analysis involved a repeated measures ANOVA or a regression analysis. Findings indicated that participants’ age predicted CPR performance. Receiving real-time CPR feedback led to a statistically significant improvement in performance, and the introduction of hospital noises did not predict CPR performance. Findings may be used to enhance individual performance of CPR, which may benefit society through improved patient care during cardiac arrest.