Thesis (Ph. D.)--Brown University, 1980. / Vita. "Chronological list of writings, speeches and unpublished papers by Cret": leaves 219-223. "Writings about Paul Philippe Cret and his architecture": leaves 224-230. Bibliography: leaves 237-250. Also issued in print.

Thesis (Ph. D.)--Brown University, 1980. / Vita. "Chronological list of writings, speeches and unpublished papers by Cret": leaves 219-223. "Writings about Paul Philippe Cret and his architecture": leaves 224-230. Bibliography: leaves 237-250.

Depuis plusieurs années, il est devenu plus aisé de détecter et d’étudier les mécanismes biologiques in cellulo grâce aux techniques d’imagerie optique que sont la fluorescence, la bioluminescence et la chimiluminescence. Bien que la fluorescence soit la technique la plus employée de nos jours, la bioluminescence et la chimiluminescence, qui sont la conséquence d’une cascade de réactions (bio)chimiques, sont très étudiées depuis quelques décennies. En effet, elles permettent de contourner la source des problèmes rencontrés dans l’utilisation d’un fluorophore : la lumière excitatrice. La chimiluminescence est par conséquent une méthode de choix pour s’affranchir de l’auto-fluorescence tissulaire. Le 1,2-dioxétane est un des motifs chimiluminescent qui, par décomposition, peut générer un état excité sur un fluorophore auquel il est connecté, autorisant ainsi sa luminescence intrinsèque. Ainsi, le but de ce projet de thèse a été de développer et d’étudier des nouvelles sondes chémiluminescentes à motif 1,2-dioxétane à coeurs naphtolique et phénolique, compatibles avec le vivant pour une détection ciblée de complexes enzymatiques. La stratégie envisagée passait par la préparation d'une plateforme chimiluminescente comportant un motif 1,2-dioxétane thermiquement stable, sur laquelle il est possible de faire varier le déclencheur (i.e. possibilité d'adapter cette plateforme à l'analyte ou événement que l'on souhaite détecter) et d'accrocher un fluorophore NIR. Deux méthodes ont été tentées : d’une part une greffe d’une version hydrosoluble d’un fluorophore connu (i.e. le Nile red) pour réaliser un transfert d’énergie à travers les liaisons (i.e. TBET), et d’autre part un couplage à un complexe de lanthanide permettant un transfert d’énergie à travers l’espace (i.e. CRET). / Since several years, it is easier to exploit biological phenomena in cellulo through technologies dealing with bioimaging. This method gathers fluorescence, bioluminescence and chemiluminescence. Even though fluorescence is the most employed technic, bioluminescence and chemiluminescence, being the consequence of (bio)chemical reaction, have been widely studied for decades. In fact, they can avoid the main problems encountered in fluorophore use: exciting light. Chemiluminescence is thus the appropriate approach to avoid biological autofluorescence. 1,2-dioxetane is one of the moieties that, upon decomposition, can generate an excited state on a connected fluorophore, giving rise to its intrinsic luminescence. The aim of our project was to develop and study new 1,2-dioxetan chemiluminescent probes based on phenol or naphthol moieties, for targeted enzymatic complexes detection with in cellulo and in vivo bioimaging. The strategy relied on the synthesis of chemiluminescent scaffolds comprising thermally stable 1,2-dioxetan, on which the trigger and the connected NIR fluorophore can be easily diversified. Two methods have been attempted: 1) coupling to a water-soluble version of a known fluorophore (i.e. Nile red) allowing an energy transfer through bonds (i.e. TBET) 2) connection with a lanthanide complex giving rise to an energy transfer through space (i.e. CRET).

This thesis explores the creation of the Virginia’s War Memorial Carillon in relation to the persistent significance of the Civil War in Virginia. By focusing on the debates about Virginia’s War Memorial Library, Tomb of the Unknown Soldier, and Carillon, this thesis reconstructs the sentiments and historical legacy that shaped the multitude of decisions leading to the creation of Virginia’s World War memorial. Virginia seriously considered two other proposals for war memorials—the War Memorial Library and the Virginia Tomb of the Unknown Soldier—before ultimately constructing the War Memorial Carillon. Concerns for appropriateness and residual attachments to the Lost Cause of the Civil War inform the debates about the best memorial to represent Virginia and honor the soldiers, sailors, marines, and women from Virginia who fought in the World War.

Made available in DSpace on 2015-03-13T17:08:18Z (GMT). No. of bitstreams: 1 UbiraciMSM.pdf: 2917234 bytes, checksum: 41d4e2d86894576356127de3941e6c83 (MD5) Previous issue date: 2000-08-31 / Petr?leo Brasileiro SA - PETROBRAS / Through an integrated approach, using litho, chrono and biostratigraphic data, the relative importance of climate variations and tectonics were recognized in rift sediments of the onshore Potiguar Basin, Northeast Brazil. Concepts of sequence stratigraphy were applied as a template to integrate sedimentological and geochemical data (oxygen isotopes), as well as quantitative palynologic methods to address and recognize the main depositional patterns produced in a rift basin. The main objective was to address the relative importance of climate changes and tectonics to the resultant stratigraphic architecture. The results of computer simulations of sedimentary basin fills of rift basins were quite useful to test working hypothesis and mimic the process of filling a half graben during a rift event. The studied section includes a neovalanginian-eobarremian (Lower Cretaceous) rift interval from the Pend?ncia Formation, located in the southwestern portion of Umbuzeiro Graben, in the offshore Potiguar Basin. The depositional setting is interpreted as progradational deltaic system entering a lake from its flexural margin. Sismoestratigraphyc and well logs analyses allowed to interpret two regressive intervals (Green and Yellow Sequences), separated by a broad transgressive interval (Orange Sequence), known as the Livramento Shale. The depositional history encompass three stages: two tectonically active phases, during the deposition of the Green and Yellow Sequences, and a tectonically quiescent phase, during the deposition of the Orange Sequence. Paleoclimatic interpretation, based on quantitative palynology and geochemical data (��18O), suggests a tendency to arid conditions during the tectonically active phases and wet conditions during the tectonically quiescent phase. Stratigraphic modeling and backstripping techniques, supported by paleoclimatic/paleoecologic interpretations provide a powerful methodology to evaluate the tectonic and climatic controls on tectonic lakes / A partir da integra??o de dados lito, bio e sismoestratigr?ficos, paleoclim?ticos e geoqu?micos (��18O), e utilizando os conceitos da estratigrafia de seq??ncias, bem como das t?cnicas de modelagem estratigr?fica e descarregamento sedimentar, foi poss?vel diferenciar os efeitos tect?nicos e clim?ticos na sedimenta??o de um rifte continental. A se??o estudada compreende o intervalo neovalanginiano-eobarremiano (Cret?ceo Inferior) da Forma??o Pend?ncia, na por??o SW do Graben de Umbuzeiro, Bacia Potiguar emersa, constitu?dos predominantemente por dep?sitos delt?icos e lacustrinos. A an?lise da arquitetura deposicional do intervalo de estudo atrav?s da se??es s?smicas e perf?s el?tricos de po?os da ?rea, permite interpretar dois grandes intervalos regressivos (Seq??ncias Verde e Amarela), separados por um n?vel transgressivo (Seq??ncia Laranja) de express?o regional, conhecido como Folhelho Livramento . No geral, a evolu??o do intervalo de estudo compreende duas fases de maior atividade tect?nica durante a deposi??o das Seq??ncias Verde e Amarela, separadas por um per?odo de quiesc?ncia durante a deposi??o da Seq??ncia Laranja. Os dois per?odos de maior atividade tect?nica mostram uma evolu??o paleoclim?tica com tend?ncia de aridez em dire??o ao topo do intervalo (lago cada vez mais raso), enquanto o per?odo de quiesc?ncia registra uma tend?ncia de condi??es cada vez mais ?midas. A simula??o de modelos estratigr?ficos (programa STRATA vers?o 2.14), bem como a utiliza??o da t?cnica de descarregamento sedimentar (programa BASS vers?o 1.0) foram de grande utilidade para um melhor entendimento da evolu??o tectono-sedimentar da ?rea de estudo, permitindo uma maior seguran?a na separa??o dos efeitos tect?nicos e clim?ticos no registro estratigr?fico das seq??ncias deposicionais

Made available in DSpace on 2015-02-24T19:48:44Z (GMT). No. of bitstreams: 1 SilvanaPPG_TESE_pag119_final.pdf: 4384081 bytes, checksum: f4e3889e03bd2b77ef4e8f1b271723a8 (MD5) Previous issue date: 2012-08-06 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / The Northeast relief was described by the Pediplanation Model. This action discards the theoretical basis of post-Cretaceous tectonic evolution of the landscape. Through this model the Massif Pereiro - MP, Borborema Province, was established as part of the Tablelands Area Residual Sertanejos. The present work aims to establish the post- Cretaceous morphotectonic evolution of the MP by geomorphological and geological mapping using Geographic Information System, Remote Sensing and dating of sediments by Single Aliquot Regenerative-dose (SAR). The MP is contained in the core semi-arid, annual precipitation of 600-800 mm / year. The MP is NE-SW, is limited by Shear Zone Jaguaribe (ZCJ) and Portalegre Shear Zone (ZCPa), the same attitude, and crossed by several other shear zones. These shear zones show evidence of brittle Cenozoic reactivation, mostly as normal faults and shallow crustal level. The Quaternary sedimentation around the MP focuses on fault escarpments in a general pattern cascade, where ages decrease from the summits of the steep foothills. The ages of 51 sediment samples indicate a correlation with global climate following pulses: Last Interestadial-UI, the Last Glacial Maximum - LGM and the transition Pleistocene / Holocene, while the latter focus on 18 of 51 samples dated. This study also finds evidence of a new quaternary basin, here called Merejo Basin. Through these results it is concluded that no evidence of post-Cretaceous tectonic evolution of morphological MP, as their retreat along the fault scarps, invariably following the trend of the shear zones. The erosion of cliffs in large time scale is controlled by weakness zones generated by faults on the other hand the erosion of cliffs in short time, with the formation of deposits and colluvial horizons pedogenizados, has climate control. It was also found that in the study area there is a preponderance of past and current tectonic erosion processes on the morphological evolution / O relevo do Nordeste foi descrito por meio do modelo de pediplana??o. Esta base te?rica descarta a atua??o da tect?nica p?s-cret?cea na evolu??o da paisagem. Atrav?s deste modelo o Maci?o do Pereiro MP, Prov?ncia Borborema, foi definido como parte do Dom?nio dos Planaltos Residuais Sertanejos. O presente trabalho tem por objetivo estabelecer a evolu??o morfotect?nica p?s-cret?cea do MP, atrav?s da cartografia geol?gica e geomorfol?gica com uso de Sistema de Informa??o Geogr?fica, Sensoriamento Remoto e data??o de sedimentos por Single Aliquot Regenerative-dose (SAR). O MP est? contido no n?cleo semi?rido, de precipita??o anual entre 600 a 800 mm/ano. O MP tem dire??o NE-SW, ? limitado pela Zona de Cisalhamento de Jaguaribe (ZCJ) e Zona de Cisalhamento Portalegre (ZCPa), de mesma atitude, e atravessado por v?rias outras zonas de cisalhamento. Estas zonas de cisalhamento apresentam evid?ncias de reativa??o fr?gil cenozoica, na sua maioria como falhas normais e de n?vel crustal raso. A sedimenta??o quatern?ria em torno do MP se concentra em escarpas de falhas, em um padr?o geral em cascata, onde as idades diminuem das cimeiras aos sop?s das escarpas. As idades de 51 amostras de sedimentos indicam correla??o com seguintes pulsos clim?ticos globais: ?ltimo Interestadial- UI, o ?ltimo M?ximo Glacial - UMG e a transi??o Pleistoceno/Holoceno, sendo que nesta ?ltima concentram-se 18 das 51 amostras datadas. O presente trabalho tamb?m encontra evid?ncias de uma nova bacia quatern?ria, aqui denominada de Bacia Merejo. Atrav?s destes resultados conclui-se que h? evidencia de tect?nica p?s-cret?cea na evolu??o morfol?gica do MP, pois as suas escarpas recuam paralelamente ?s falhas, seguindo invariavelmente o trend das zonas de cisalhamento. A eros?o das escarpas em grande escala de tempo ? controlada pelas zonas de fraqueza geradas pelos falhamentos, por outro lado ? eros?o das escarpas em curtos espa?os de tempos, com a forma??o dos dep?sitos coluvionares e horizontes pedogenizados, possui controle clim?tico. Concluise ainda que na ?rea de estudo haja a preponder?ncia da tect?nica pret?rita e atual sobre os processos erosivos na evolu??o morfol?gica